Patents by Inventor Brian J. Wainger

Brian J. Wainger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to treat neurodegenerative diseases
    Patent number: 10350191
    Abstract: The specification provides compositions and methods to treat neurodegenerative diseases.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: July 16, 2019
    Assignees: Children's Medical Center Corporation, The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Clifford J. Woolf, Brian J. Wainger, Evangelos Kiskinis, Kevin Eggan
  • METHODS TO TREAT NEURODEGENERATIVE DISEASES
    Publication number: 20190125718
    Abstract: The specification provides compositions and methods to treat neurodegenerative diseases.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 2, 2019
    Inventors: Clifford J. Woolf, Brian J. Wainger, Evangelos Kiskinis, Kevin Eggan
  • Conversion of somatic cells into functional spinal motor neurons, and methods and uses thereof
    Patent number: 9770471
    Abstract: The present invention provides methods of transdifferentiation of somatic cells, for example, directly converting a somatic cell of a first cell type, e.g., a fibroblast into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for converting a somatic cell, e.g., a fibroblast into a motor neuron, e.g., an induced motor neuron (iMN) with characteristics of a typical motor neuron. The present invention also relates to an isolated population comprising induced motor neurons (iMNs), compositions and their use in the treatment of motor neuron diseases such as ALS and SMA. In particular, the present invention relates to direct conversion of a somatic cell to an induced motor neuron (iMN) having motor neuron characteristics by increasing the protein expression of at least three motor-neuron inducing (MN-inducing) factors selected from Lhx3, Ascl1, Brn2, Myt1l, Isl1, Hb9, Ngn2 or NeuroD1 in a somatic cell, e.g.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: September 26, 2017
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Kevin Carl Eggan, Clifford J. Woolf, Brian J. Wainger, Justin K. Ichida, Esther Yesde Son
  • CONVERSION OF SOMATIC CELLS INTO NOCICEPTORS, AND METHODS OF USE THEREOF
    Publication number: 20170044492
    Abstract: The present invention provides methods of transdifferentiation of somatic cells, e.g., a fibroblast, into a nociceptor cell, e.g., an induced nociceptor (iNociceptors) with characteristics of a typical nociceptor cell. The present invention also relates to an isolated population comprising iNociceptors, compositions, their use in the study of cellular and molecular mechanisms of peripheral pain generation and peripheral neuropathy, use in in vitro drug discovery assays, pain research, as their use in the treatment of nociceptive pain related diseases or disorders. In particular, the present invention relates to direct conversion of a somatic cell to an iNociceptor cell having nociceptor characteristics by increasing the protein expression of five nociceptor inducing factors selected from Asc11, Myt11, Isl2, Ngn1, Klf7 in a somatic cell, to convert the fibroblast to an iNociceptors which express the markers of adult nociceptors.
    Type: Application
    Filed: December 5, 2014
    Publication date: February 16, 2017
    Inventors: Clifford J. Woolf, Brian J. Wainger, Kevin Eggan, Isaac Chiu, Justin Ichida
  • CONVERSION OF SOMATIC CELLS INTO FUNCTIONAL SPINAL MOTOR NEURONS, AND METHODS AND USES THEREOF
    Publication number: 20150023927
    Abstract: The present invention provides methods of transdifferentiation of somatic cells, for example, directly converting a somatic cell of a first cell type, e.g., a fibroblast into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for converting a somatic cell, e.g., a fibroblast into a motor neuron, e.g., an induced motor neuron (iMN) with characteristics of a typical motor neuron. The present invention also relates to an isolated population comprising induced motor neurons (iMNs), compositions and their use in the treatment of motor neuron diseases such as ALS and SMA. In particular, the present invention relates to direct conversion of a somatic cell to an induced motor neuron (iMN) having motor neuron characteristics by increasing the protein expression of at least three motor-neuron inducing (MN-inducing) factors selected from Lhx3, Ascl1, Brn2, Myt1l, Isl1, Hb9, Ngn2 or NeuroD1 in a somatic cell, e.g.
    Type: Application
    Filed: August 17, 2012
    Publication date: January 22, 2015
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Kevin Carl Eggan, Clifford J. Woolf, Brian J. Wainger, Justin K. Ichida, Esther Yesde Son