Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: Systems, methods, techniques and apparatuses of throttle bodies are disclosed. One exemplary embodiment is an intake system comprising a throttle body device including a first interface structured to be coupled to an intake manifold, and a second interface including a receiving bore; and an intake adapter including a third interface including a radial groove structured to house a seal device, and a fourth interface structured to be coupled to an intake conduit, wherein the third interface of the intake of the intake adapter is structured to be inserted into the receiving bore of the second interface of the throttle body device.

Abstract: An exchange template framework for a data platform. A data provider of the data platform instructs the data platform to generate an exchange template based on compliance rules. In response to determining by the data platform to initiate a compliance report, the data platform maps evidence items for the compliance report from one or more source tables using a data field mapper of the exchange template. The data platform generates compliance program specific views based on the evidence items mapped from the source tables and generates an anonymized view based on the compliance program specific views using an anonymization layer of the exchange template. The data platform provides the anonymized view to an assessor using one or more validation scripts of the exchange template.

Abstract: Systems and methods for performing a simulated phishing attack are provided. A simulated attack server can send a simulated attack email including a unique identifier to a target. The simulated attack server can receive a reply email including the unique identifier from the target. The simulated attack server can extract the unique identifier from the reply email. The simulated attack server can determine a match between the unique identifier and an identity of the target. The simulated attack server can record a target failure, responsive to determining the match between the unique identifier and the identity of the target.

Abstract: Systems and methods for performing a simulated phishing attack are provided. A simulated attack server can send a simulated attack email including a unique identifier to a target. The simulated attack server can receive a reply email including the unique identifier from the target. The simulated attack server can extract the unique identifier from the reply email. The simulated attack server can determine a match between the unique identifier and an identity of the target. The simulated attack server can record a target failure, responsive to determining the match between the unique identifier and the identity of the target.

Abstract: Systems and methods for performing a simulated phishing attack are provided. A simulated attack server can send a simulated attack email including a unique identifier to a target. The simulated attack server can receive a reply email including the unique identifier from the target. The simulated attack server can extract the unique identifier from the reply email. The simulated attack server can determine a match between the unique identifier and an identity of the target. The simulated attack server can record a target failure, responsive to determining the match between the unique identifier and the identity of the target.

Abstract: Systems and methods for performing a simulated phishing attack are provided. A simulated attack server can send a simulated attack email including a unique identifier to a target. The simulated attack server can receive a reply email including the unique identifier from the target. The simulated attack server can extract the unique identifier from the reply email. The simulated attack server can determine a match between the unique identifier and an identity of the target. The simulated attack server can record a target failure, responsive to determining the match between the unique identifier and the identity of the target.

Abstract: Systems and methods for performing a simulated phishing attack are provided. A simulated attack server can send a simulated attack email including a unique identifier to a target. The simulated attack server can receive a reply email including the unique identifier from the target. The simulated attack server can extract the unique identifier from the reply email. The simulated attack server can determine a match between the unique identifier and an identity of the target. The simulated attack server can record a target failure, responsive to determining the match between the unique identifier and the identity of the target.

Abstract: Systems and methods for performing a simulated phishing attack are provided. A simulated attack server can send a simulated attack email including a unique identifier to a target. The simulated attack server can receive a reply email including the unique identifier from the target. The simulated attack server can extract the unique identifier from the reply email. The simulated attack server can determine a match between the unique identifier and an identity of the target. The simulated attack server can record a target failure, responsive to determining the match between the unique identifier and the identity of the target.

Abstract: Systems and methods for performing a simulated phishing attack are provided. A simulated attack server can send a simulated attack email including a unique identifier to a target. The simulated attack server can receive a reply email including the unique identifier from the target. The simulated attack server can extract the unique identifier from the reply email. The simulated attack server can determine a match between the unique identifier and an identity of the target. The simulated attack server can record a target failure, responsive to determining the match between the unique identifier and the identity of the target.

Abstract: A pretensioner for a three point vehicle safety restraint seat belt has a mounting for one end of the seat belt. The mounting has a first member fixed to a load bearing part of the vehicle and a second member attached to the end of the seat belt. A force reservoir, such as a pyrotechnic unit, moves the second member relative to the first member in a pretensioning direction in response to activation by a crash sensor.

Abstract: A pretensioner for a three point seat belt has a cylinder adapted to be attached to a structural member of a vehicle and a piston disposed within the cylinder. A pyrotechnic means moves the piston in a direction that is longitudinal relative to the cylinder in a pretensioning direction. A slider bar is oriented substantially parallel to a longitudinal axis of the cylinder. A seat belt webbing is looped around the slider bar such that the seat belt webbing can freely move along a portion of the slider bar that is oriented substantially parallel to a longitudinal axis of the cylinder so long as the pyrotechnic means for moving the piston has not been activated. A cable extends from the piston and loops around the seat belt webbing to cause the seat belt webbing to move along the slider bar in a pretensioning direction when the pyrotechnic means for moving the piston is activated.

Abstract: A pretensioner for a three point seat belt has a cylinder adapted to be attached to a structural member of the vehicle and a piston disposed within the cylinder. The piston can move translationally relative to the cylinder in a pretensioning direction. A flexible member is arranged in a curved profile with a seat belt webbing being attached to the flexible member. The flexible member has a first end that can be pulled by the piston and a second end releasably connected to an exterior of the cylinder such that when the piston moves translationally relative to the cylinder the second end of the flexible member moves translationally relative to the cylinder along the exterior of the cylinder.

Abstract: A new cultivar of Chamelaucium, ‘Sarah's Delight’ that is characterized by its early blooming, its large vibrant pink flowers with crimson centers, and its red flower buds.

Abstract: A new cultivar of Chamelaucium, ‘Moonlight Delight’, that is characterized by its large clear white flowers with crimson centers, with the white color retained as the flower age, its red flower buds, its long harvest period as a cut flower, its flowers with overlapping petals, its calyxes with the free apex portion remaining mostly white, and its early blooming habit.

Abstract: A new cultivar of Chamelaucium, ‘Strawberry Surprise’ that is characterized by its flowers that are a rich pink in color, its flower buds that are hot pink in color, its flower clusters that bloom from axels up to 12 cm the length of the stems (longer than typical), and its late blooming period.