Abstract: Atmospheric Triphasic Chromatography (ATC) method comprising the steps introducing a raw plant material containing cannabinoids into a non-polar solvent, dissolving the cannabinoids extracted from the raw plant material in the non-polar solvent and removing the raw plant material to obtain a target solution, performing potency analysis and cannabinoid extract profile analysis of the target solution. The method further includes the steps of preparing an aqueous caustic solution and mixing the target solution with the aqueous caustic solution to obtain a mixture followed by separating the mixture into a first phase solution and a second phase solution, and removing the first phase solution to obtain a caustic target solution and acidifying the caustic target solution to produce precipitation of an undesirable compound in the caustic target solution.