Abstract: A system for cleaning printheads used for printing on a roll of web product is provided herein. The system includes at least one printhead configured to print ink on the roll of web product to form a roll of printed web product, and a cleaning device comprising a wipe. The system further includes a controller configured to perform a cleaning operation by causing application of a cleaning additive to a portion of the wipe and causing the cleaning device to translate across the printhead to cause the portion of the wipe to be wiped across the printhead to clean the printhead. The wipe is applied with a fluid, such as water, or a non-wetted cleaning product. Multiple passes of the cleaning device can be utilized, such as where the portion of the wipe has different or no cleaning additives. Cleaning assistance, such as vibration or heat, can be utilized.