Abstract: A monitor either usable in cooperation with or apart from a portable cooler to maintain a temperature of medications. The cooling device defines an interior volume for holding the medications, a power source including at least one of a 12 volt DC and an attachable 110 volt AC supply. A portable monitoring device is integrated with the cooling device and further includes a processor driven circuitry for recording a temperature associated with the interior volume containing the medications. The recorded temperature is compared at determined intervals to a preset programmed temperature range and, upon exceeding the programmed range, the device alerts the user. An alternative monitoring device is envisioned to ship with the medication from the manufacturer and remain with the medication container until the medications are used.