Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the Fc?RI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the C?2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the C?2 domain of IgE) and/or the ability to disassociate IgE from the Fc?RI receptor for instance at pharmaceutically-relevant concentrations.

Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the Fc?RI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the C?2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the C?2 domain of IgE) and/or the ability to disassociate IgE from the Fc?RI receptor for instance at pharmaceutically-relevant concentrations.

Abstract: A filter housing is provided. The filter housing includes a circumferential rib provided on an outer surface thereof. The filter housing also includes a first longitudinal rib provided on the outer surface thereof. The first longitudinal rib connects and extends away from the circumferential rib along a length of the filter housing. The first longitudinal rib defines a first thickness thereof. The first thickness tapers towards the circumferential rib. The filter housing further includes a second longitudinal rib provided on the outer surface thereof. The second longitudinal rib is provided opposing the first longitudinal rib. The second longitudinal rib connects and extends away from the circumferential rib along the length of the filter housing. The second longitudinal rib defines a second thickness thereof. The second thickness tapers towards the circumferential rib.

Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the Fc?RI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the C?2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the C?2 domain of IgE) and/or the ability to disassociate IgE from the Fc?RI receptor for instance at pharmaceutically-relevant concentrations.

Abstract: A filter housing is provided. The filter housing includes a circumferential rib provided on an outer surface thereof. The filter housing also includes a first longitudinal rib provided on the outer surface thereof. The first longitudinal rib connects and extends away from the circumferential rib along a length of the filter housing. The first longitudinal rib defines a first thickness thereof. The first thickness tapers towards the circumferential rib. The filter housing further includes a second longitudinal rib provided on the outer surface thereof. The second longitudinal rib is provided opposing the first longitudinal rib. The second longitudinal rib connects and extends away from the circumferential rib along the length of the filter housing. The second longitudinal rib defines a second thickness thereof. The second thickness tapers towards the circumferential rib.