Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.

Abstract: A method of smoothing spectral data recorded by a spectrometer including successively fitting a plurality of spline curves to the spectral data, each spline curve having a different number of knots. A knot position of each knot, other than end point knots, in each spline curve is determined based upon a measure of fit of points of a previously fitted one of the spline curves having fewer knots to the spectral data. The method further includes selecting one of the spline curves as a smoothed data curve of the spectral data based upon a model selection criterion.

Abstract: A system, method, and platform for detecting natural resources. Gravitational waves are measured utilizing one or more sensor systems associated with an exploration area. The one or more sensor systems include at least an accelerometer capturing measurements in a range of 1 microhertz to 100 microhertz that are stored in a memory associated with the accelerometer. A fast fourier transform is performed for the measurements to generate processed signals. Natural resources are determined proximate the one or more sensor systems from the processed signals.

Abstract: In connection with a data distribution architecture, client-side “deduplication” techniques may be utilized for data transfers occurring among various file system nodes. In some examples, these deduplication techniques involve fingerprinting file system elements that are being shared and transferred, and dividing each file into separate units referred to as “blocks” or “chunks.” These separate units may be used for independently rebuilding a file from local and remote collections, storage locations, or sources. The deduplication techniques may be applied to data transfers to prevent unnecessary data transfers, and to reduce the amount of bandwidth, processing power, and memory used to synchronize and transfer data among the file system nodes. The described deduplication concepts may also be applied for purposes of efficient file replication, data transfers, and file system events occurring within and among networks and file system nodes.

Abstract: To resolve an issue related to the calibration of optical cameras in transducer-based mid-air haptic systems, the magnification of the motion induced on an optical camera by an acoustic field modulated at specific frequencies reveals very small temporal variations in video frames. This quantized distortion is used to compare different acoustic fields and to solve the calibration problem in an automatized manner. Further, mechanical resonators may be excited by ultrasound when it is modulated at the resonant frequency. When enough energy is transferred and when operating at the correct frequency, a user in contact with the device can feel vibration near areas of largest displacement. This effect can be exploited to create devices which can produce haptic feedback while not carrying a battery or exciter when in the presence of an ultrasonic source.

Abstract: An equipment mounting system for mounting equipment to a support structure is described. An equipment mounting system including: (i) a mounting plate having defined therein a plate aperture of a particular shape; (ii) a bolt having a shaft portion including a threaded portion and a non-threaded portion that is of a complementary shape that complements the particular shape of the plate aperture; and (iii) a washer having defined therein a scored aperture that includes multiple radially extending scorings. In an assembled configuration of the mounting plate, the bolt and the washer, the plate aperture of the particular shape aligns with the scoring aperture such that both of the plate aperture and the scoring aperture receive the non-threaded portion of the complementary shape, and the particular shape of the mounting plate engages with the complementary shape of the bolt to prevent rotational displacement of the bolt around the mounting plate.

Abstract: The present disclosure generally relates to partial integrated core-shell investment casting molds that can be assembled into complete molds. Each section of the partial mold may contain both a portion of a core and portion of a shell. Each section can then be assembled into a mold for casting of a metal part. The partial integrated core-shell investment casting molds and the complete molds may be provided with filament structures corresponding to cooling hole patterns on the surface of the turbine blade or the stator vane, which provides a leaching pathway for the core portion after metal casting. The invention also relates to core filaments that can be used to supplement the leaching pathway, for example in a core tip portion of the mold.

Abstract: A traction battery includes a battery array having a stack of cells, wherein a first of the cells includes a terminal having a projecting portion extending from a body of the cell and a curved portion disposed on a distal end of the projecting portion. A busbar has a connecting portion defining a slot with a pair of first opposing sides and a pair of second opposing sides. The connecting portion further has a pair of flaps, each pivotally attached to one of the second opposing sides such that the flaps oppose each other. The terminal is mechanically joined to the connecting portion with the curved portion of the terminal in contact with at least one of the flaps.

Abstract: The present invention is directed to a prolipid composition that penetrates the stratum corneum. More particularly, the invention is directed to a prolipid composition that provides personalized benefits by rapidly restoring the skins natural lipid balance. Such a composition results in elongated fatty acid and/or lipid production deep in the stratum corneum and near the surface of the stratum lucidum. The composition at least comprises a fatty acid, fatty ester and/or an acylglycerol and an activator of a peroxisome proliferator-activated receptor.

Abstract: An APL field switch includes a number of ports that transmit power to APL field devices connected to spurs extending from the ports. The APL Power Class of each port can be dynamically set by a user to enable more efficient allocation of power to the ports to meet the needs of the connected field devices.

Abstract: One embodiment is an apparatus for inhibiting accidental contact by a human with a tail rotor connected to an empennage of an aircraft. The apparatus includes an inverted V-tail connected to an empennage of the aircraft forward of the tail rotor, the inverted V-tail stabilizer comprising a first V-tail stabilizer on a side of the empennage to which the tail rotor is connected and a second V-tail stabilizer on a side of the empennage opposite the side of the empennage to which the tail rotor is connected; and a shroud bar having a first end connected to an outboard end of the first V-tail stabilizer and a second end opposite the first end connected to the empennage aft of the tail rotor, wherein a horizontal distance from the shroud bar to the tail rotor is greater than a length of an arm of the human.

Abstract: A gyroscopic roll stabilizer for a boat includes an enclosure mounted to a gimbal for rotation about a gimbal axis and configured to maintain a below-ambient pressure, and a flywheel assembly including a flywheel and flywheel shaft, with the flywheel assembly rotatably mounted inside the enclosure for rotation about a flywheel axis. The gyroscopic roll stabilizer also includes a motor operative to rotate the flywheel assembly and disposed inside the enclosure. A motor cooling circuit is configured to transfer heat away from the motor. The motor cooling circuit has a closed fluid pathway for recirculating cooling fluid therein. The fluid pathway includes a fluid channel jointly defined by the motor and the enclosure and having the cooling fluid therein. The gyroscopic roll stabilizer is configured to transfer heat away from the motor to the cooling fluid. Related methods are also disclosed.

Abstract: An example device includes an array of sensor modules. A sensor module includes a body to be positioned in alignment with a planar target, a light source coupled to the body to emit light to the planar target along a source optical path, and a plurality of light sensors coupled to the body. Each light sensor is to sense a different wavelength of light received from the planar target along a sensor optical path. The sensor optical path is different from the source optical path. The bodies of the array of sensor modules are arranged in a planar tiling pattern with respect to a longitudinal axis of the planar target.

Abstract: A gyroscopic roll stabilizer includes an enclosure, a flywheel assembly, a bearing, a motor, and a bearing cooling circuit. The enclosure is mounted to a gimbal for rotation about a gimbal axis and configured to maintain a below-ambient pressure. The flywheel assembly includes a flywheel and flywheel shaft. The bearing rotatably mounts the flywheel assembly inside the enclosure for rotation about a flywheel axis. The bearing has an inner race and an outer race. The inner race is affixed to the flywheel shaft, and the outer race is held rotationally fixed relative to the enclosure. The motor is operative to rotate the flywheel assembly. The bearing cooling circuit is configured to transfer heat away from the bearing by recirculating cooling fluid along a closed fluid pathway. The gyroscopic roll stabilizer is configured to transfer heat away from the inner and/or outer race of the bearing to the cooling fluid.

Abstract: A system includes: a form factor device sized and shaped to accommodate a subject's skull; an ultrasound array comprising a plurality of transducer elements attached to the form factor device, wherein the plurality of transducer elements are configured to: emit ultrasound pulses through the subject's skull for performing a neuro-modulation of the subject's brain during use of the system, and receive ultrasound signals from the subject's skull and brain in response to the ultrasound pulses being emitted; and a controller coupled to the ultrasound array, wherein the controller is configured, during use of the system, to: generate at least one image depicting at least a portion of the subject's skull and brain based on, at least in part, the received ultrasound signals received, and adapt the neuro-modulation of the subject's brain based on, at least in part, the at least one image during use of the system.

Abstract: A service monitoring system executing on one or more processors may have operations that are determined by control information. Control over the operation of the service monitoring system can be exerted through the use of a graphical interface. The graphical interface may present the control information of a new or existing correlation search definition for user interaction. The service monitoring system may maintain a data store of key performance indicator (KPI) data, where a KPI value in the data store is produced by a KPI-defining search query that derives the value from machine data associated with one or more entities that perform a monitored service. A correlation search definition of the service monitoring system determines how a search of the KPI data is conducted, how its data is evaluated to determine whether a triggering condition has been met, and, if so, determines what triggered action is to be initiated.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for correcting finite floating-point numerical simulation and optimization. Defining a loss function within a simulation space composed of a plurality of voxels each having an initial degree of freedom, the simulation space encompassing one or more interfaces of the component; defining an initial structure for the one or more interfaces in the simulation space; calculating, using a computer system with a finite floating-point precision, values for an electromagnetic field at each voxel using a finite-difference time domain solver to solve Maxwell's equations; and determining, for each voxel, whether to increase a respective numerical precision of respective values representing behavior of the electromagnetic field at the voxel above a threshold precision by the computer system and, in response, assigning one or more additional degrees of freedom to the voxel.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for designing a multimodal photonic component. In one aspect, a method includes defining a loss function within a simulation space including multiple voxels and encompassing features of the multimodal photonic component. The loss function corresponds to a target output mode profile for an input mode profile, where the target output mode profile includes a relationship between a set of operating conditions and one or more supported modes of the multimodal photonic component at a particular operative wavelength. The initial structure is defined for one or more features, where at least some of the voxels corresponding to features have a dimension smaller than a smallest operative wavelength of the multimodal photonic component, and values for structural parameters for the features are determined so that a loss according to the loss function is within a threshold loss.