Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the Fc?RI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the C?2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the C?2 domain of IgE) and/or the ability to disassociate IgE from the Fc?RI receptor for instance at pharmaceutically-relevant concentrations.

Abstract: An electronic payment and authentication system that includes features to verify the authenticity of a payer, validate debit data, and facilitate debit (as opposed to credit) payment transactions. The electronic payment system allows a consumer to purchase items and services via a network while utilizing a debit transaction. The invention provides merchants with the ability to verify the identity of the consumer, determine if the consumer is a good debit transaction risk, and retrieve debit data associated with a particular consumer.

Abstract: A system for forecasting a chance of success of a user locating employment, assisting the user to become employed, or both, is disclosed. The system has at least one client device associated with a user, a network interface for receiving an input from the GUI, and sending an output to a server, wherein the output is associated with the at least one task. A machine learning module has a data repository, a monitoring module, a predictive analyzer module and a multivariate analyzing module that utilizes an output confidence metric from the data repository to perform predictive modeling to correlate outputs associated with the at least one task with confidence data to output a quantification of chance of success at finding the employment. A method for forecasting a chance of success of a user locating employment, assisting the user to become employed, or both is provided as well.

Abstract: A field device I/O connector includes a base and an I/O module removably mounted on the base for transmitting I/O signals along an I/O channel. A set of electrical connectors mounted on the base connect the base to a field device. The electrical connectors, the base, and the I/O module mounted on the base cooperate to define the I/O channel. The I/O channel includes a conversion circuit to convert between I/O signals and a digital data format output from the field device I/O connector. The base and I/O module also cooperate to define a diagnostic circuit connected to the portion of the I/O channel extending through the I/O module. The diagnostic circuit extends to a diagnostic logic circuit that may be included on the base, in the I/O module, or away from the field device I/O connector.

Abstract: Example embodiments are directed to systems and methods for denying power to unauthorized power loads within a spherical waveguide bounded by the Earth's surface. One or more eigenmodes of the Earth-ionosphere waveguide may be computed based on a mathematical model incorporating electrical properties of the terrestrial surface and plasma physics of the ionosphere. A phased array of wave guide couplers, each including an array of electrically-connected waveguide-coupling elements, may be configured at different geographic locations for coupling to the one or more eigenmodes and generating standing waves in the Earth-ionosphere waveguide. Power loads may be detected via power reflections, and power nodes and nulls of the standing waves may be steered with respect to specified locations by adjusting relative phases and/or amplitudes of the waveguide couplers. Locations of power loads may be triangulating reflections. Power nulls of the standing waves may be steered to locations of unauthorized power loads.

Abstract: The invention is directed to systems, methods and apparatus for securing documents. The system comprises a server having a processor and a data storage device for storing documents, at least one document provider connected to the server, the at least one document provider operable to provide user documents to the server for storage in the data storage device, the user documents containing at least one object of security concern, and at least one document consumer connected to the server, the at least one document consumer operable to receive the user documents containing the at least one object of security concern from the server.

Abstract: A heating, ventilation, air conditioning and refrigeration system includes a diffuser comprising a plurality of diffuser elements located between a blower driving airflow through the system and a refrigeration coil used to cool the airflow prior to the distribution of the airflow to a building. Locating diffusers between the blower and the refrigeration coil reduces the extent to which the airflow carries moisture from condensate on the refrigeration coil, and can prevent circulation of air backwards through the refrigeration coil.

Abstract: A method of smoothing spectral data recorded by a spectrometer including successively fitting a plurality of spline curves to the spectral data, each spline curve having a different number of knots. A knot position of each knot, other than end point knots, in each spline curve is determined based upon a measure of fit of points of a previously fitted one of the spline curves having fewer knots to the spectral data. The method further includes selecting one of the spline curves as a smoothed data curve of the spectral data based upon a model selection criterion.

Abstract: Fabrics made for apparel, tents, sleeping bags and the like, in various composites, constructed such that there is at least one metal layer, forming a radiant barrier to reduce heat loss via radiation from the human body, and insulating this metal layer from heat loss via conduction, and a process for its manufacture.

Abstract: A method and circuit for protecting circuit elements in a traffic control system from an overcurrent condition. In accordance with an embodiment, the circuit includes a current sensing element, a switching element, and a microcontroller. The circuit monitors first and second operating parameters and compares the first operating parameter with a first reference parameter and the second operating parameter with a second reference parameter. In response to the first operating parameter exceeding the first reference parameter and the second operating parameter exceeding the second reference parameter, the microcontroller generates a control signal to open the switching element.

Abstract: A joint attachment system for a reconfigurable truss includes a first joint attachment having a first pivot axis and a second joint attachment having a second pivot axis. The first joint attachment and second joint attachment form a concentric spherical joint linkage when attached to a first body member and a second body member, respectively. The first pivot axis of the first joint attachment intersects the second pivot axis of the second joint attachment at a single point X which defines a center of the concentric spherical joint linkage. The concentric spherical joint linkage is configured to allow the addition of one or more joint attachments and body members to the truss node. In addition, the concentric spherical joint linkage is configured to allow the removal of one or more joint attachments and body members from the truss node.

Abstract: The invention relates to a computer-implemented system and method for automatic collection, analysis and reporting of data relating to a cybersecurity threat. The method may comprise the steps of: presenting an interface through which an executable can be configured and automatically generated; transmitting the executable to a client to enable the client to execute the executable on client systems to automatically collect forensic data; receiving from the client an encrypted data package that includes the forensic data; using a forensic toolset to automatically analyze the forensic data; presenting an option to select one or more of at least two types of output reports designed for different types of readers; inputting the analysis files into an automatic report generator to automatically generate the types of output reports selected by the client; and sending the output reports selected by the client to the client.

Abstract: Described are reminiscence therapy and media sharing platform, methods, and systems for a patient user which provide an immediate and First Mobile Application positive impact on emotional functioning inpatients with dementia, major neurocognitive disorders, social isolation, traumatic brain injury (TBI), and psychiatric conditions such as posttraumatic stress disorder, by reducing anxiety, depression, and overall emotional distress.

Abstract: Methods for designing a mode-selective optical device including one or more optical interfaces defining an optical cavity include: defining a loss function within a simulation space encompassing the optical device, the loss function corresponding to an electromagnetic field having an operative wavelength within the optical device resulting from an interaction between an input electromagnetic field at the operative wavelength and the one or more optical interfaces of the optical device; defining an initial structure for each of the one or more optical interfaces, each initial structure being defined using a plurality of voxels; determining values for at least one structural parameter and/or at least one functional parameter of the one or more optical interfaces by solving Maxwell's equations; and defining a final structure of the one or more optical interfaces based on the values for the one or more structural and/or functional parameters.

Abstract: A gyroscopic roll stabilizer includes an enclosure, a flywheel assembly, a bearing, a motor, and a bearing cooling circuit. The enclosure is mounted to a gimbal for rotation about a gimbal axis and configured to maintain a below-ambient pressure. The flywheel assembly includes a flywheel and flywheel shaft. The bearing rotatably mounts the flywheel assembly inside the enclosure for rotation about a flywheel axis. The bearing has an inner race and an outer race. The inner race is affixed to the flywheel shaft, and the outer race is held rotationally fixed relative to the enclosure. The motor is operative to rotate the flywheel assembly. The bearing cooling circuit is configured to transfer heat away from the bearing by recirculating cooling fluid along a closed fluid pathway. The gyroscopic roll stabilizer is configured to transfer heat away from the inner and/or outer race of the bearing to the cooling fluid.

Abstract: An electronic docking system includes a dock comprising a recess having at least one vertically oriented side wall and a recess bottom face, wherein the dock comprises a pogo pin connector extending from the recess bottom face; a first protrusion extending in a substantially perpendicular direction from the recess bottom face and a second protrusion extending in a substantially perpendicular direction from the recess bottom face; and an electronic device includes an electrical contact configured to contact the pogo pin connector; a first alignment slot configured to accept the first protrusion and a second alignment slot configured to accept the second protrusion, wherein at least a portion of the exterior perimeter of the recess comprises a rounded or beveled edge.

Abstract: A convertible I/O signal processor is convertible between different operating configurations for connecting multiple field devices to the I/O signal processor by selectable types of electrical connectors such as cables, terminal blocks, and the like. The I/O signal processor includes a signal processing module connected to a signal processor and an interface module removably connected to the signal processing module. The interface module includes electrical connectors for receiving/transmitting I/O signals from and to field devices. The interface module and the signal processing module define I/O channels extending between the electrical connectors and the signal processor. The interface module in embodiments includes I/O module connectors that enable removable I/O modules to be interposed in the I/O channels.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for tuning photonic device performance. In one aspect, a method includes receiving an initial photonic device configuration including multiple coupling structures and multiple photonic components. A first amount of light coupling between a first photonic component and a second photonic component of the multiple photonic components is received, which depends upon a subset of the coupling structures that are located between the first photonic component and the second photonic component. One or more coupling structures of the subset of coupling structures located between the first photonic component and the second photonic component are determined to be removed to cause the light coupling between the first photonic component and the second photonic component to change from the first amount of coupling to a target amount of coupling.

Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.