Abstract: A method for processing imagewise exposed silver halide light sensitive motion picture photographic print film elements, the method comprising: i) classifying imagewise exposed print film elements containing cyan, magenta and yellow dye-forming couplers present at levels sufficient to provide Visual densities of at least 3.3 when completely consumed as either a relatively high silver containing element or a relatively low silver containing element; ii) providing a developer solution comprising greater than 2.1 g/l Color Developing Agent CD-2, greater than 0.3 and less than 2.

Abstract: Processing color motion picture film to yield a dye-only, “silverless” soundtrack enables reduced silver levels to be incorporated into all three color image records of a motion picture print film while still providing a good soundtrack signal in the resulting processed film.

Abstract: A method is described for splicing together overlapping ends of first and second lengths of photographic film strips of common film strip width, comprising positioning a bonding element between an overlapping end of the first length of photographic film and a corresponding overlapped end of the second length of photographic film, and heating the bonding element to effect an adhesive bond between such film ends, wherein the bonding element comprises an induction heating receptive support and thermoplastic adhesive layers on each side of the support, and wherein the heating of the bonding element is performed by induction heating. The present invention allows for the preparation of photographic film splices, consisting of either homogeneous or dissimilar film bases, using a bonding element and induction heating to provide smooth yet strong splices. In particular, the invention enables successful splicing of acetate support (e.g., cellulose triacetate (CTA)) based films and polyester support (e.g.

Abstract: Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.

Abstract: Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.

Abstract: Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.

Abstract: Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.

Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.

Abstract: Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZFI-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.

Abstract: Methods for the design of exogenous regulatory molecules, comprising a DNA-binding domain and a functional domain, are provided. The methods rely on the identification, isolation and characterization of regulatory DNA sequences obtained on the basis of their accessibility in cellular chromatin.

Abstract: Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.

Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.

Abstract: Methods for the design of exogenous regulatory molecules, comprising a DNA-binding domain and a functional domain, are provided. The methods rely on the identification, isolation and characterization of regulatory DNA sequences obtained on the basis of their accessibility in cellular chromatin.

Abstract: Disclosed are a composition of chemically defined components which support the in vitro chondrogenesis of mesenchymal progenitor cells, a method for in vitro chondrogenic induction of such progenitor cells and a method of forming human chondrocytes in vitro from such progenitor cells.

Abstract: A suitcase is provided with shoulder straps in one of its broad sides so that the suitcase can be carried in the manner of a back pack. The straps are retractable into flat engagement with the broad side and the suitcase includes a handle permitting it to be carried in a conventional manner.