Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient or a sample from the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.

Abstract: A system in accordance with the present invention prevents tampering of a device. The system includes an encrypted digital signature and a decryption attempt. The encrypted digital signature represents a software configuration of the device and is retained in a non-volatile memory of the device. The decryption attempt is received from a source seeking access to the device. The system determines whether the digital signature matches the decryption attempt.

Abstract: A system in accordance with the present invention prevents tampering of a device. The system includes an encrypted digital signature and a decryption attempt. The encrypted digital signature represents a configuration of the device and is retained in a non-volatile memory of the device. The decryption attempt is received from a source seeking access to the device. The system determines whether the digital signature matches the decryption attempt.