Abstract: An occlusion device (e.g., for treatment of the left atrial appendage) includes a framework and a biocompatible covering disposed over at least a part of the framework. The framework may include a proximal portion, a middle portion, and a distal portion, wherein: the proximal portion includes a first hub that has a fixed first diameter; the middle portion has a second diameter and includes a plurality of beams extending from the first hub to a distal portion, wherein each of the plurality of beams is connected to an adjacent beam by a first circumferentially extending column of strut pairs; and the distal portion has a third diameter. In one or more embodiments, the framework includes improved circumferential strength and minimizes foreshortening.

Abstract: A left atrial appendage closure implant may include a support frame including a first bend extending from a proximal collar to a second bend, a first segment extending from the second bend to a third bend, a second segment extending from the third bend to a fourth bend, and a third segment extending from the fourth bend to a distal collar, wherein the support frame is actuatable from a first constrained position to a second flowering position to a third mid-deployment position to a fourth unconstrained position. An implant may include a self-expanding support frame having a circumference and a central longitudinal axis, a membrane disposed over at least a portion of the support frame, and a plurality of anchors arranged into a first row and a second row such that the first row and the second row form a staggered pattern about the circumference of the support frame.

Abstract: A stent has a first end region, a middle region, and a second end region, each region including a plurality of strut columns. The stent includes at least one barb. Each barb in an expanded state is at an angle relative to the outer surface of the stent.

Abstract: A drug delivery device that uses centrifugal force to deliver a drug to a body lumen wall. The drug delivery device comprises an impeller that includes an impeller shaft; an impeller head at the distal end of the impeller shaft; a drug lumen; an impeller housing; and a housing shaft attached to the impeller housing. In use, the drug is advanced along the drug lumen to the impeller head; at least the impeller head is rotated so that when drug exits the drug lumen, the centrifugal force of the rotating impeller causes the drug to move radially outward from the drug delivery device, towards and into the body lumen wall.

Abstract: An implantable medical device having barbs reducing in height and/or changing angle as the implantable medical device transitions for an expanded state to a constrained state is disclosed which may lessen the risk of injury associated with the removal and/or repositioning of a deployed device. Within the main body of the device may be positioned a plurality of fixation struts having an end secured to the main body and a barb end exiting the main body at a point of egress and extending radially outwards from the main body. The fixation struts may be secured to the main body such that the distance between the point of attachment of the secured end of a fixation strut and the respective point of egress from the main body its free barb forming end is greater in the constrained than expanded state.

Abstract: Occlusion device for an atrial appendage, the device having proximal and distal ends and a central axis and comprising a cage-like structure formed of struts, the struts having proximal strut ends and distal strut ends, wherein at the proximal end of the device the struts extend towards the central axis and are connected to each other at their proximal strut ends, and wherein at least some of the struts are connected to each other at their distal strut ends within the cage-like structure so that the struts form an atraumatic distal end of the device.

Abstract: A valve consisting of a motor that rotates a cylinder to perform various functions in controlling liquid flow. The operation being controlled by a cam operated switch to start and stop cylinder in the various cycles.

Abstract: A valve consisting of a motor that rotates a cylinder to perform various functions in controlling liquid flow. The operation being controlled by a cam operated switch to start and stop cylinder in the various cycles.