Patents by Inventor Brian K. Erickson
Brian K. Erickson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230132372Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.Type: ApplicationFiled: July 28, 2021Publication date: April 27, 2023Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
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Patent number: 11334624Abstract: Targeted distributing of reports containing historical process control information to particular user devices via a communications network. A curating service permits assigning a score to each report based on an interest level value of the historical process control information to a user associated with each user device and/or an urgency value of the historical process control information. Routing reports to user devices based on the score raises visibility of the historical process control information without overburdening the communications network.Type: GrantFiled: July 17, 2019Date of Patent: May 17, 2022Assignee: AVEVA SOFTWARE, LLCInventors: Brian K. Erickson, Greg C. Clinton, Vinay T. Kamath, Abhijit Manushree
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Publication number: 20220018847Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.Type: ApplicationFiled: July 28, 2021Publication date: January 20, 2022Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
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Patent number: 11169155Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.Type: GrantFiled: June 3, 2016Date of Patent: November 9, 2021Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
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Patent number: 11105810Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.Type: GrantFiled: November 22, 2019Date of Patent: August 31, 2021Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
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Patent number: 11085927Abstract: Described herein is a kit of materials prepared for assays that involve determining relative abundance and/or absolute abundance of various targeted peptides. The kit may comprise trigger versions of target peptides with masses offset from the respective target peptides by predetermined and known amounts. The trigger peptides may be present in amounts that may be readily detected via a mass spectrometry analysis. When mixed with samples that are analyzed, detection of the trigger peptides indicates where in the mass-spectrometer output the target peptide may be found. The kit may include a predetermined amount of synthetic versions of one or more of the target peptides. A measured relative abundance of this synthetic peptide relative to that of the target peptides yields an absolute quantitative value of the target peptide. Also disclosed is a method of preparing a plurality of samples to be submitted for mass spectrometer analysis in parallel.Type: GrantFiled: June 1, 2017Date of Patent: August 10, 2021Assignee: President and Fellows of Harvard CollegeInventors: Robert A. Everley, Brian K. Erickson, Christopher Michael Rose, Steven P. Gygi
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Publication number: 20200174007Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.Type: ApplicationFiled: November 22, 2019Publication date: June 4, 2020Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
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Publication number: 20200012683Abstract: Targeted distributing of reports containing historical process control information to particular user devices via a communications network. A curating service permits assigning a score to each report based on an interest level value of the historical process control information to a user associated with each user device and/or an urgency value of the historical process control information. Routing reports to user devices based on the score raises visibility of the historical process control information without overburdening the communications network.Type: ApplicationFiled: July 17, 2019Publication date: January 9, 2020Inventors: Brian K. Erickson, Greg C. Clinton, Vinay T. Kamath, Abhijit Manushree
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Publication number: 20190310264Abstract: Described herein is a kit of materials prepared for assays that involve determining relative abundance and/or absolute abundance of various targeted peptides. The kit may comprise trigger versions of target peptides with masses offset from the respective target peptides by predetermined and known amounts. The trigger peptides may be present in amounts that may be readily detected via a mass spectrometry analysis. When mixed with samples that are analyzed, detection of the trigger peptides indicates where in the mass-spectrometer output the target peptide may be found. The kit may include a predetermined amount of synthetic versions of one or more of the target peptides. A measured relative abundance of this synthetic peptide relative to that of the target peptides yields an absolute quantitative value of the target peptide. Also disclosed is a method of preparing a plurality of samples to be submitted for mass spectrometer analysis in parallel.Type: ApplicationFiled: June 1, 2017Publication date: October 10, 2019Applicant: President and Fellows of Harvard CollegeInventors: Robert A. Everley, Brian K. Erickson, Christopher Michael Rose, Steven P. Gygi
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Publication number: 20180209985Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.Type: ApplicationFiled: June 3, 2016Publication date: July 26, 2018Applicants: President and Fellows of Harvard College, Dana-Faber Cancer Institute, Inc.Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
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Publication number: 20170083015Abstract: Targeted distributing of reports containing historical process control information to particular user devices via a communications network. A curating service permits assigning a score to each report based on an interest level value of the historical process control information to a user associated with each user device and/or an urgency value of the historical process control information. Routing reports to user devices based on the score raises visibility of the historical process control information without overburdening the communications network.Type: ApplicationFiled: September 20, 2016Publication date: March 23, 2017Applicant: Invensys Systems, Inc.Inventors: Brian K. Erickson, Greg C. Clinton, Vinay T. Kamath, Abhijit Manushree