Abstract: A steam or reactant system is provided for a roller compactor to provide improved compaction or functional characteristic of powdered materials, such as active pharmaceutical ingredients. The steam or reactants can be added through conduits terminating in nozzles adjacent the nip zone of the compaction rollers. The injection nozzles can be directed tangentially from the above the rollers or laterally from the sides of the rollers. In one embodiment, the moisture is in the form of steam. The resulting compacting sheet has improved compaction characteristics and reduced compression variability.

Abstract: A steam or reactant system is provided for a roller compactor to provide improved compaction or functional characteristic of powdered materials, such as active pharmaceutical ingredients. The steam or reactants can be added through conduits terminating in nozzles adjacent the nip zone of the compaction rollers. The injection nozzles can be directed tangentially from the above the rollers or laterally from the sides of the rollers. In one embodiment, the moisture is in the form of steam. The resulting compacting sheet has improved compaction characteristics and reduced compression variability.

Abstract: A Wurster processor and a powder feed system are coupled via an eductor so as to supply dry powder through the air diverter sleeve of the Wurster for discharging onto the circulating particles during operation of the Wurster. Agglomeration and aggregation of the particles is eliminated or minimized by isolating or separating the liquid spray by the spray gun from the dry powder.

Abstract: A Wurster processor and a powder feed system are coupled via an eductor so as to supply dry powder through the air diverter sleeve of the Wurster for discharging onto the circulating particles during operation of the Wurster. Agglomeration and aggregation of the particles is eliminated or minimized by isolating or separating the liquid spray by the spray gun from the dry powder.

Abstract: A Wurster processor and a powder feed system are coupled via an eductor so as to supply dry powder through the air diverter sleeve of the Wurster for discharging onto the circulating particles during operation of the Wurster. Agglomeration and aggregation of the particles is eliminated or minimized by isolating or separating the liquid spray by the spray gun from the dry powder.

Abstract: A Wurster processor and a powder feed system are coupled via an eductor so as to supply dry powder through the air diverter sleeve of the Wurster for discharging onto the circulating particles during operation of the Wurster. Agglomeration and aggregation of the particles is eliminated or minimized by isolating or separating the liquid spray by the spray gun from the dry powder.

Abstract: The improved rotor processor of the present invention includes a stator with a rotatable rotor defining a rotor chamber in which particles are circulated for coating or layering. A spray gun mounted to the stator adjacent the rotor directs liquid into the rotor chamber, while a powder feed system mounted in the stator adjacent the rotor directs dry powder into the rotor chamber. The spray gun and powder feed system are spaced apart circumferentially so as to define a spray zone and a separate powder zone through which the circulating particles repeatedly and sequentially pass. The powder feed system includes a feed screw conveyor, an eductor, and a flexible conduit for delivering micronized powders, such as polymers or glidants, to the rotor chamber.

Abstract: A method is provided for applying polymers to coat particulate cores in a rotor processor. The processor is actuated to create a circulating bed of cores in the rotor chamber. Dry powdered glidant is introduced into the rotating bed of cores, which are simultaneously sprayed with a polymer solution. The glidant enhances processability by eliminating or minimizing agglomeration of the cores. Air from above and below the rotating bed evaporates the solution to leave a polymer layer on the cores. Layers of polymer build up on the cores until a desired thickness is achieved.

Abstract: A method of coating tablets with a high molecular weight polymer wherein the high molecular weight polymer is suspended in a non-solvent, non-aqueous liquid carrier. The liquid carrier may include a low-viscosity binder. Preferably, the binder is included in concentrations of around 1-10% by weight in solution in the carrier. The high molecular weight polymer may be micronized prior to its suspension in the liquid carrier. Once suspended, the liquid is introduced into a spray coating machine such as a partially or fully perforated pan system wherein the tablets are coated as desired.

Abstract: The method for applying a dry polymer layer to particulate cores circulating as a bed in a rotor processor includes the steps of loading the cores into the processor, rotating the rotor of the processor and supplying air into the processor to create the bed, spraying the cores with a wetting agent, and supplying dry polymer powder into the bed so as to adhere onto the wetted cores and thereby build up a continuous smooth layer of polymer on the cores. The wetting agent includes a plasticizer so as to facilitate uniform layering of the micronized polymer powder.

Abstract: The improved rotor processor of the present invention includes a stator with a rotatable rotor defining a rotor chamber in which particles are circulated for coating or layering. A spray gun mounted to the stator adjacent the rotor directs liquid into the rotor chamber, while a powder feed system mounted in the stator adjacent the rotor directs dry powder into the rotor chamber. The spray gun and powder feed system are spaced apart circumferentially so as to define a spray zone and a separate powder zone through which the circulating particles repeatedly and sequentially pass. The powder feed system includes a feed screw conveyor, an eductor, and a flexible conduit for delivering micronized powders, such as polymers or glidants, to the rotor chamber.

Abstract: The improved Wurster of the present invention includes an air diverter which supplies a flow of air in a radial direction adjacent the spray nozzle body and spray nozzle, so as to force the product away from the nozzle during the spraying process. The air diverter includes a sleeve with air passages therein, a manifold connected to the sleeve and to a source of secondary pressurized air or gas, and a collar to mount the assembled air diverter onto the perforated plate of the Wurster apparatus. In operation, the air diverter allows the spray pattern from the nozzle to more fully develop, allows more complete atomization of the spray solution, and allows for higher spray rates with little or no agglomeration of the product.

Abstract: The improved Wurster of the present invention includes an air diverter which supplies a flow of air in a radial direction adjacent the spray nozzle body and spray nozzle, so as to force the product away from the nozzle during the spraying process. The air diverter includes a sleeve with air passages therein, a manifold connected to the sleeve and to a source of secondary pressurized air or gas, and a collar to mount the assembled air diverter onto the perforated plate of the Wurster apparatus. In operation, the air diverter allows the spray pattern from the nozzle to more fully develop, allows more complete atomization of the spray solution, and allows for higher spray rates with little or no agglomeration of the product.

Abstract: The improved Wurster of the present invention includes an air diverter which supplies a flow of air in a radial direction adjacent the spray nozzle body and spray nozzle, so as to force the product away from the nozzle during the spraying process. The air diverter includes a sleeve with air passages therein, a manifold connected to the sleeve and to a source of secondary pressurized air or gas, and a collar to mount the assembled air diverter onto the perforated plate of the Wurster apparatus. In operation, the air diverter allows the spray pattern from the nozzle to more fully develop, allows more complete atomization of the spray solution, and allows for higher spray rates with little or no agglomeration of the product.

Abstract: The improved Wurster of the present invention includes an air diverter which supplies a flow of air in a radial direction adjacent the spray nozzle body and spray nozzle, so as to force the product away from the nozzle during the spraying process. The air diverter includes a sleeve with air passages therein, a manifold connected to the sleeve and to a source of secondary pressurized air or gas, and a collar to mount the assembled air diverter onto the perforated plate of the Wurster apparatus. In operation, the air diverter allows the spray pattern from the nozzle to more fully develop, allows more complete atomization of the spray solution, and allows for higher spray rates with little or no agglomeration of the product.

Abstract: The improved Wurster of the present invention includes an air diverter which supplies a flow of air in a radial direction adjacent the spray nozzle body and spray nozzle, so as to force the product away from the nozzle during the spraying process. The air diverter includes a sleeve with air passages therein, a manifold connected to the sleeve and to a source of secondary pressurized air or gas, and a collar to mount the assembled air diverter onto the perforated plate of the Wurster apparatus. In operation, the air diverter allows the spray pattern from the nozzle to more fully develop, allows more complete atomization of the spray solution, and allows for higher spray rates with little or no agglomeration of the product.