Patents by Inventor Brian K. Shull

Brian K. Shull has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYCOSYLATED VALPROIC ACID ANALOGS AND USES THEREOF
    Publication number: 20150119346
    Abstract: Glycosylated valproic acid and its analogs are provided. In some embodiments, the glycosylated valproic acid and its analogs have improved solubility and are ideal for drug delivery to treat a variety of diseases.
    Type: Application
    Filed: December 29, 2014
    Publication date: April 30, 2015
    Inventors: Norman S. HEYMAN, Brian K. SHULL
  • Glycosylated valproic acid analogs and uses thereof
    Patent number: 8921533
    Abstract: Glycosylated valproic acid and its analogs are provided. In some embodiments, the glycosylated valproic acid and its analogs have improved solubility and are ideal for drug delivery to treat a variety of diseases.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: December 30, 2014
    Assignee: Chromatin Technologies
    Inventors: Norman S. Heyman, Brian K. Shull
  • GLYCOSYLATED VALPROIC ACID ANALOGS AND USES THEREOF
    Publication number: 20130029924
    Abstract: Glycosylated valproic acid and its analogs are provided. In some embodiments, the glycosylated valproic acid and its analogs have improved solubility and are ideal for drug delivery to treat a variety of diseases.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Applicant: Chromatin Technologies
    Inventors: Norman S. HEYMAN, Brian K. Shull
  • Glycoside compounds and methods of synthesis
    Patent number: 6093805
    Abstract: Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: July 25, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Brian K. Shull, Roeland J. Tuinman, Todd A. Houston, R. Erich Klemke, Masato Koreeda
  • Glycoside derivatives of acetaminophen
    Patent number: 5693767
    Abstract: Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: December 2, 1997
    Assignee: Harrier Inc.
    Inventors: R. -Erich Klemke, Masato Koreeda, Todd A. Houston, Brian K. Shull, Roeland J. Tuinman
  • Glycosylated analogs of camptothecin
    Patent number: 5677286
    Abstract: The present invention relates to chemotherapeutic agents, and more particularly, to novel analogs of camptothecin. The camptothecin analogs display increased solubility through the hydrophilicity of added non-ionic sugar substituents. In accordance with the present invention, a member from the class of novel camptothecin analogs is to be delivered in vivo as a chemotherapeutic agent to fight cancer growth in the body.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: October 14, 1997
    Assignee: The University of Michigan
    Inventors: Brian K. Shull, Clarke Slemon, Masato Koreeda
  • Water-soluble glycosylated derivatives of 1,2-dithiin compounds
    Patent number: 5453500
    Abstract: Novel water-soluble mono and disaccharides of 1,2-dithiins, as well as methods for their synthesis and the synthesis of 3,6-bis(hydroxymethyl)-1,2-dithiin, are provided. The water-soluble compounds have useful medicinal applications, e.g., as an antifungal agent or antibacterial agent in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: September 26, 1995
    Assignee: The University of Michigan
    Inventors: Masato Koreeda, Brian K. Shull, Wu Yang