Abstract: A surgical device including a cannula having a base member at a proximal end, a sidewall connected to the base member, and a bore defined by the base member and sidewall. The sidewall further has an opening into the bore between axially-extending edges of the sidewall. A configurable guide insert includes a combination track having a circular opening for insertion of a camera device and a slot opening for insertion of a cutting instrument. The configurable guide insert may be permanently or detachably coupled to the base member and is positionable in a right orientation for a procedure in a patient's right side or in a left orientation for a procedure in a patient's left side. The combination track slidably receives a camera device through the circular opening into the bore and slidably receives a surgical implement through the slot opening and into an action area outside the bore.

Abstract: The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: A secure one-way network gateway for transmitting data from a source network to a destination network is disclosed. An input circuit is for coupling to a source network and an output circuit is for coupling to an output network. A memory stores configuration data. Either a single field-programmable device or a pair of field-programmable devices coupled via a one-way link are inserted between the input circuit and the output circuit. The configuration data is loaded into the device(s) to program the device(s) to pass data from the input circuit to the output circuit, to optionally filter the data, and to prevent any data from passing from the output circuit to the input circuit. A processor is coupled to only the memory and a separate management interface. The processor receives updated configuration data via the management interface and replaces the configuration data in the memory with the updated configuration memory.

Abstract: The present disclosure provides novel 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4-diones of formula (I): The compounds of formula (I) are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: A connector plate, for mechanically and hydraulically connecting a hydraulic machine with a hydraulic attachment part, includes a plurality of hydrostatic connector recesses. Each recess has a first side that includes a first orifice opening to the hydraulic attachment part, and a second side with a second orifice opening to the hydraulic machine. The plurality of orifices are arranged so as to open in a substantially axially parallel manner with respect to a drive shaft of the hydraulic machine. A hydraulic machine includes such a connector plate, and a hydrostatic unit includes such a hydraulic machine and a hydraulic attachment part.

Abstract: A secure one-way network gateway for transmitting data from a source network to a destination network is disclosed. An input circuit is for coupling to a source network and an output circuit is for coupling to an output network. A memory stores configuration data. Either a single field-programmable device or a pair of field-programmable devices coupled via a one-way link are inserted between the input circuit and the output circuit. The configuration data is loaded into the device(s) to program the device(s) to pass data from the input circuit to the output circuit, to optionally filter the data, and to prevent any data from passing from the output circuit to the input circuit. A processor is coupled to only the memory and a separate management interface. The processor receives updated configuration data via the management interface and replaces the configuration data in the memory with the updated configuration memory.

Abstract: A secure one-way network gateway for transmitting data from a source network to a destination network is disclosed. An input circuit is for coupling to a source network and an output circuit is for coupling to an output network. A memory stores configuration data. Either a single field-programmable device or a pair of field-programmable devices coupled via a one-way link are inserted between the input circuit and the output circuit. The configuration data is loaded into the device(s) to program the device(s) to pass data from the input circuit to the output circuit, to optionally filter the data, and to prevent any data from passing from the output circuit to the input circuit. A processor is coupled to only the memory and a separate management interface. The processor receives updated configuration data via the management interface and replaces the configuration data in the memory with the updated configuration memory.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: A connector plate, for mechanically and hydraulically connecting a hydraulic machine with a hydraulic attachment part, includes a plurality of hydrostatic connector recesses. Each recess has a first side that includes a first orifice opening to the hydraulic attachment part, and a second side with a second orifice opening to the hydraulic machine. The plurality of orifices are arranged so as to open in a substantially axially parallel manner with respect to a drive shaft of the hydraulic machine. A hydraulic machine includes such a connector plate, and a hydrostatic unit includes such a hydraulic machine and a hydraulic attachment part.

Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.