Abstract: A system, device, and method for detecting leaks near an emitter is disclosed. The method includes (i) receiving, from one or more mobile sensors, a first stream of information indicative of a leak state, (ii) determining that an initial leak state exists based at least in part on the first stream of information indicative of the leak state, (iii) receiving a second stream of information indicative of a no-leak state, (iv) using a statistical model to determine that the leak state has ended based at least in part on the first stream of information and the second stream of information, (v) receiving a third stream of information indicative of the leak state, and (vi) determining that a new leak state exists, wherein the new leak state is a distinct leak state from the initial leak state.

Abstract: Embodiments of the disclosure relate to an applicator for an adhesive primer. The applicator includes a tank configured to hold the adhesive primer. The applicator also includes a peristaltic pump, having an inlet and an outlet, and a spray nozzle. A first conduit extends from an interior of the tank to the inlet of the peristaltic pump, and a second conduit extends from an outlet of the peristaltic pump to the spray nozzle. Embodiments of the present disclosure also relate to a method of applying adhesive primer to a road surface using the applicator. In the method, the adhesive primer is pumped from the tank containing the adhesive primer through the peristaltic pump to the spray nozzle. Further, the adhesive primer is sprayed from the spray nozzle onto the road surface while the applicator moves across the road surface.

Abstract: The present disclosure presents an apparatus which assists with disposal of animal excrement. The apparatus includes a conduit having a first end and a second end, wherein the first and second ends are fluidly coupled to a handle and a nozzle, respectively. The handle is fluidly coupled to a water source and provides a lever that is operably coupled to an internal valve allowing the user to control the flow rate of water through the conduit and nozzle. The apparatus further includes a splash guard that is coupled to the nozzle and extends a predetermined distance beyond the exit orifice of the nozzle. The nozzle and splash guard are engineered to produce a turbulent churning of the discharged water when the splash guard is in sufficient contact with the ground that allows for the rapid breakdown and dissolution of the animal excrement.

Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.

Abstract: The present disclosure presents an apparatus which assists with disposal of animal excrement. The apparatus includes a conduit having a first end and a second end, wherein the first and second ends are fluidly coupled to a handle and a nozzle, respectively. The handle is fluidly coupled to a water source and provides a lever that is operably coupled to an internal valve allowing the user to control the flow rate of water through the conduit and nozzle. The apparatus further includes a splash guard that is coupled to the nozzle and extends a predetermined distance beyond the exit orifice of the nozzle. The nozzle and splash guard are engineered to produce a turbulent churning of the discharged water when the splash guard is in sufficient contact with the ground that allows for the rapid breakdown and dissolution of the animal excrement.

Abstract: A fire-control display adapter for a weapon scope. The fire-control display adapter consists of a display unit positioned at the scope's objective bell and aligned in front of the scope's objective lens. A range finder calculates the distance from a target's aimpoint. A ballistic computer is communicably coupled to both the display unit and the distance sensor. The ballistic computer computes a ballistic solution and causes the display unit to display it. To power to the distance sensor and the display unit, a power source is communicably coupled to the ballistic computer. A mount detachably secures the fire-control display adapter to the weapon's rail.

Abstract: Systems and methods for providing real-time modification of cutting process programs using feedback from one or more sensors which measure one or more operational parameters of a cutting process and/or cutting apparatus. The sensor readings may be used to provide real-time modification of a motion program after such motion program has been provided to a motion controller. Examples of such operational parameters may include waterjet pump supply pressure, the abrasive mass flow rate, the force of the waterjet on the target piece, etc. The systems and methods discussed herein also utilize a cutting algorithm or program to calculate actual cut quality based on one or more sensor inputs, and to generate warnings or system shut-downs accordingly. The systems and methods discussed herein also utilize inspection devices to inspect coupons or first articles, and use the inspection data to autonomously modify motion programs and/or cutting process models without user intervention.

Abstract: Systems and methods for providing real-time modification of cutting process programs using feedback from one or more sensors which measure one or more operational parameters of a cutting process and/or cutting apparatus. The sensor readings may be used to provide real-time modification of a motion program after such motion program has been provided to a motion controller. Examples of such operational parameters may include waterjet pump supply pressure, the abrasive mass flow rate, the force of the waterjet on the target piece, etc. The systems and methods discussed herein also utilize a cutting algorithm or program to calculate actual cut quality based on one or more sensor inputs, and to generate warnings or system shut-downs accordingly. The systems and methods discussed herein also utilize inspection devices to inspect coupons or first articles, and use the inspection data to autonomously modify motion programs and/or cutting process models without user intervention.

Abstract: Embodiments of the present disclosure support systems and methods providing functionality for performing anomaly detection and remediation. In an aspect, a dataset comprising transaction data stored in a plurality of data sources is obtained. One or more clustering algorithms are executed against the dataset to identify a plurality of clusters. At least one cluster of the plurality of clusters corresponds to a portion of the dataset comprising an anomaly. A classifier may be used to determine a cause of the anomaly and one or more actions to eliminate the anomaly may be initiated. Data derived from the dataset subsequent to the one or more actions may be output. For example, the output may be a report generated based on the dataset.

Abstract: The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined according to the present method include trisomies and monosomies of any one or more of chromosomes 1-22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample.

Abstract: The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined according to the present method include trisomies and monosomies of any one or more of chromosomes 1-22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample.

Abstract: The invention includes a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions.

Abstract: A method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions.

Abstract: Systems and methods for providing real-time modification of cutting process programs using feedback from one or more sensors which measure one or more operational parameters of a cutting process and/or cutting apparatus. The sensor readings may be used to provide real-time modification of a motion program after such motion program has been provided to a motion controller. Examples of such operational parameters may include waterjet pump supply pressure, the abrasive mass flow rate, the force of the waterjet on the target piece, etc. The systems and methods discussed herein also utilize a cutting algorithm or program to calculate actual cut quality based on one or more sensor inputs, and to generate warnings or system shut-downs accordingly. The systems and methods discussed herein also utilize inspection devices to inspect coupons or first articles, and use the inspection data to autonomously modify motion programs and/or cutting process models without user intervention.

Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.

Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.

Abstract: The various embodiments described herein include methods, systems and/or devices used to visualize data. In one aspect, a method is performed by a computing system having one or more processors and memory. The method includes (1) receiving a request from a user to visualize data, the data stored in a graph dataflow processing system, and (2) in response to the request, invoking an interactive graphical user interface (GUI) for display to the user, the GUI including a first set of visualization data corresponding to a first subset of the data.

Abstract: The present invention provides minimally invasive imaging probe/medical device having a frictional element integrated therewith for reducing non-uniform rotational distortion near the distal end of a medical device, such as an imaging probe which undergoes rational movement during scanning of surrounding tissue in bodily lumens and cavities.

Abstract: The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined according to the present method include trisomies and monosomies of any one or more of chromosomes 1-22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample.