Patents by Inventor Brian Ko

Brian Ko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting cytochrome P450 family 7 subfamily a member 1 (CYP7A1) expression
    Patent number: 12553050
    Abstract: RNAi agents (e.g., CYP7A1 RNAi agents) for inhibiting the expression of the CYP7A1 gene, compositions including the RNAi agents conjugated to a targeting moiety, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more RNAi agents (e.g., CYP7A1 RNAi agents). Delivery of the RNAi agent(s) to liver cells in vivo inhibits CYP7A1 gene expression and treats a CYP7A1 disease or a CYP7A1-associated disease.
    Type: Grant
    Filed: March 21, 2025
    Date of Patent: February 17, 2026
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Bernard Allan, Brian Ko, Pawan Kumar, Naim Nazef, Jason Pickens
  • COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450 FAMILY 7 SUBFAMILY A MEMBER 1 (CYP7A1) EXPRESSION
    Publication number: 20250297260
    Abstract: RNAi agents (e.g., CYP7A1 RNAi agents) for inhibiting the expression of the CYP7A1 gene, compositions including the RNAi agents conjugated to a targeting moiety, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more RNAi agents (e.g., CYP7A1 RNAi agents). Delivery of the RNAi agent(s) to liver cells in vivo inhibits CYP7A1 gene expression and treats a CYP7A1 disease or a CYP7A1-associated disease.
    Type: Application
    Filed: March 21, 2025
    Publication date: September 25, 2025
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Bernard Allan, Brian Ko, Pawan Kumar, Naim Nazef, Jason Pickens
  • Cross domain key management
    Patent number: 12333530
    Abstract: Methods, systems, and devices for data management are described. A datacenter may include one or more servers and an offline key storage system. The datacenter may receive, via a server and from a multi-party computation (MPC) coordinator, a first request to access a key share associated with an MPC node. The server may transmit a second request for the key share associated with the MPC node via a first cross domain communication path to an offline key storage system. The offline key storage system may verify a digital signature included with the second request. The offline key storage system may transmit a response including the key share that is encrypted using an encryption key associated with the MPC node to the server via a second cross domain communication path. The server may transmit a communication including the encrypted key share to the MPC coordinator.
    Type: Grant
    Filed: July 31, 2023
    Date of Patent: June 17, 2025
    Inventors: Yolanda Liu, Leonardo D. M. Machado, Pavel Zakharov, Roman Popenov, Larry Liu, Brian Ko
  • CROSS DOMAIN KEY MANAGEMENT
    Publication number: 20250045742
    Abstract: Methods, systems, and devices for data management are described. A datacenter may include one or more servers and an offline key storage system. The datacenter may receive, via a server and from a multi-party computation (MPC) coordinator, a first request to access a key share associated with an MPC node. The server may transmit a second request for the key share associated with the MPC node via a first cross domain communication path to an offline key storage system. The offline key storage system may verify a digital signature included with the second request. The offline key storage system may transmit a response including the key share that is encrypted using an encryption key associated with the MPC node to the server via a second cross domain communication path. The server may transmit a communication including the encrypted key share to the MPC coordinator.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 6, 2025
    Inventors: Yolanda Liu, Leonardo D. M. Machado, Pavel Zakharov, Roman Popenov, Lary Liu, Brian Ko