Abstract: Systems and methods are provided for a digital holography system. The subject system uses wide-bandwidth data, monitor beams, and signal beams to form a digital interference, yielding a reference phase and angle that can be used to compensate DH phase errors. DH systems disclosed herein can provide an ability to sense and correct for phase errors and/or instabilities to perform DH vibrometry. Such a system provides a compact and low-cost solution to improve sensing in, for example, systems that rely on phase stability for precision 3D and/or vibration imaging.

Abstract: A system for performing 3-dimensional (3-D) digital holographic refractometry includes a splitter to split a source light into a first light beam and a second light beam. A tomographic optical setup shines a sample with the first light beam and generates an image light beam. A detector array generates an interferogram signal in response to being simultaneously exposed to the image light beam and the second light beam.

Abstract: A holography imaging system includes a first laser, a second laser, a transmitter optical system, a receiver optical system, and a detector array. The first laser has a constant frequency, and the second laser has a non-constant frequency. The transmitter optical system can illuminate a target simultaneously using portions of the first and second laser signals. The receiver optical system can focus a returned light onto the detector array. A first and second illumination point sources can direct portions of the first and second laser signals onto the detector array. The first and second illumination point sources are located in-plane with a pupil of the receiver optical system. The system can detect simultaneously holograms formed on the detector array based on the returned light and the portions of the first and second laser signals directed by the first and second illumination point sources.

Abstract: Disclosed are methods for treating conditions characterized by anemia or red blood cells dysfunction by administering an agent that increases the level of endogenous LCAT or LCAT activity. Additionally disclosed are methods of treating conditions wherein red blood cells have reduced function in relation to deformability, oxygenation, increased adhesion and aggregability, reduced nitric oxide function, or decreased life-span, increased free cholesterol, or abnormal phospholipid content. Also disclosed are methods for treating conditions characterized by an abnormal concentration of free cholesterol in red blood cells and methods of normalizing the free cholesterol content of red blood cells.

Abstract: The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous solution) with fluorescent sterol substrates. The present disclosure also relates to a method for evaluating efficacy of a therapeutic agent for stimulating LCAT and for determining endogenous LCAT activity in a patient. Also disclosed are kits that are used to carry out the aforementioned methods and methods.

Abstract: Disclosed are methods for treating conditions characterized by anemia or red blood cells dysfunction by administering an agent that increases the level of endogenous LCAT or LCAT activity. Additionally disclosed are methods of treating conditions wherein red blood cells have reduced function in relation to deformability, oxygenation, increased adhesion and aggregability, reduced nitric oxide function, or decreased life-span, increased free cholesterol, or abnormal concentration of free cholesterol in red blood cells and methods of normalizing the free cholesterol content of red blood cells.

Abstract: The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous solution) with fluorescent sterol substrates. The present disclosure also relates to a method for evaluating efficacy of a therapeutic agent for stimulating LCAT and for determining endogenous LCAT activity in a patient. Also disclosed are kits that are used to carry out the aforementioned methods and methods.

Abstract: Disclosed are methods for treating conditions characterized by anemia or red blood cells dysfunction by administering an agent that increases the level of endogenous LCAT or LCAT activity. Additionally disclosed are methods of treating conditions wherein red blood cells have reduced function in relation to deformability, oxygenation, increased adhesion and aggregability, reduced nitric oxide function, or decreased life-span, increased free cholesterol, or abnormal phospholipid content. Also disclosed are methods for treating conditions characterized by an abnormal concentration of free cholesterol in red blood cells and methods of normalizing the free cholesterol content of red blood cells.

Abstract: Disclosed are methods for treating conditions characterized by anemia or red blood cells dysfunction by administering an agent that increases the level of endogenous LCAT or LCAT activity. Additionally disclosed are methods of treating conditions wherein red blood cells have reduced function in relation to deformability, oxygenation, increased adhesion and aggregability, reduced nitric oxide function, or decreased life-span, increased free cholesterol, or abnormal phospholipid content. Also disclosed are methods for treating conditions characterized by an abnormal concentration of free cholesterol in red blood cells and methods of normalizing the free cholesterol content of red blood cells.

Abstract: A method for frequency modulated continuous wave LADAR imaging is provided. The method comprises the steps of generating a chirped laser signal and a constant-frequency laser signal, forming a target laser signal from the chirped laser signal and the constant-frequency laser signal and forming a local oscillator laser signal from the chirped laser signal and the constant-frequency laser signal. The method further comprises delaying or frequency shifting the local oscillator laser signal and directing the target laser signal to a target. The method further comprises combining a returned signal received from the target with the delayed or frequency shifted local oscillator laser signal to form a combined received signal, and capturing the combined received signal with a plurality of image sensors.