Patents by Inventor Brian L. Bray

Brian L. Bray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV FUSION INHIBITOR PEPTIDES WITH IMPROVED BIOLOGICAL PROPERTIES
    Publication number: 20120040891
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Application
    Filed: August 31, 2011
    Publication date: February 16, 2012
    Inventors: John J. Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nicolai A. Tvermoes, Barbara E. Johnston, Paul E. Friedrich
  • HIV fusion inhibitor peptides with improved biological properties
    Patent number: 8034899
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: October 11, 2011
    Assignee: Trimeris, Inc.
    Inventors: John Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nicolai A. Tvermoes, Barbara E. Johnston, Paul E. Friedrich
  • NOVEL METHODS OF SYNTHESIS FOR THERAPEUTIC ANTIVIRAL PEPTIDES
    Publication number: 20100261876
    Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.
    Type: Application
    Filed: September 25, 2008
    Publication date: October 14, 2010
    Inventors: Brian L. Bray, Barbara E. Johnston, Stephen E. Schneider, Nicolai A. Tvermoes, Huyi Zhang, Paul E. Friedrich
  • HIV FUSION INHIBITOR PEPTIDES WITH IMPROVED BIOLOGICAL PROPERTIES
    Publication number: 20090105143
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Application
    Filed: October 20, 2008
    Publication date: April 23, 2009
    Inventors: John J. Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nicolai A. Tvermoes, Barbara E. Johnston, Paul E. Friedrich
  • HIV fusion inhibitor peptides with improved biological properties
    Patent number: 7456251
    Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: November 25, 2008
    Assignee: Trimeris, Inc.
    Inventors: John Dwyer, Brian L. Bray, Stephen E. Schneider, Huyi Zhang, Nikolai A. Tvermores, Barbara E. Johnston, Paul E. Friedrich
  • 1,8-diazabicyclo[5.4.0]undec-1(7)-enium cyanide and method of making thereof
    Patent number: 5576430
    Abstract: The compound 1,8-diazabicyclo[5.4.0]undec-1(7)-enium cyanide is the reaction product of acetone cyanohydrin and 1,8-diazabicyclo [5.4.0]undec-7-ene.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: November 19, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: John J. Partridge, Brian L. Bray
  • Method for removing osmium from nucleosides
    Patent number: 5438132
    Abstract: A process for removing osmium from an aqueous solution of nucleosides comprising adding hydrogen sulfide, an aromatic pi base such as pyridine, and a mineral acid. The osmium is precipitated out of solution.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: August 1, 1995
    Assignee: Glaxo Group Limited
    Inventors: Brian L. Bray, Maynard E. Lichty, John J. Partridge, John P. Turnbull
  • Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone
    Patent number: 5329008
    Abstract: Synthesis of the triol of the following formula (I) from an alcohol of the formula (IV): ##STR1## via steps including protecting and then cyanating the alcohol to yield a cyanide, isomerization of the double bond, hydrolysis followed by reduction of the cyanide back to an alcohol and cis-dihydroxylation of the double bond.
    Type: Grant
    Filed: April 7, 1993
    Date of Patent: July 12, 1994
    Assignee: Glaxo Inc.
    Inventors: John J. Partridge, Brian L. Bray
  • Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone from a 2,3-unsaturated-1-cyclopentanylpurinone
    Patent number: 5233041
    Abstract: Synthesis of the triol of formula (I) or its amine-protected derivative from a cyclopentene of the formula (II) or its amine-protected derivative: ##STR1## via steps including oxidation to the aldehyde, migration of the double bond, reduction of the aldehyde moiety back to the alcohol grouping and 1,2-cis-dihydroxylation of the double bond.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: August 3, 1993
    Assignee: Glaxo Group Limited
    Inventors: Brian L. Bray, Maynard E. Lichty, John J. Partridge, John P. Turnbull
  • Kinetic resolution of pyridazinones using lipase
    Patent number: 5053338
    Abstract: A kinetic resolution of pyridazinones of the following formula (A): ##STR1## where R.sup.1 is alkyl by enzymatic hydrolysis results in good optical purity of the phenolic product. This is significant considering the distance in the molecule (A) from the C-5 chiral center to the site of hydrolysis.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: October 1, 1991
    Assignee: Glaxo Inc.
    Inventors: Brian L. Bray, John J. Partridge