Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.1, R.sup.2 and W are defined in the specification. These compounds are useful as antibiotic agents.

Abstract: There are provided certain 13-alkyl-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.

Abstract: There are provided certain 13-halo-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.

Abstract: Substituted phenylacetic acid amide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R.sub.1 is H, OH or CH.sub.3 ; R.sub.2 is straight chain alkenyl, branched chain or cyclic hydrocarbon having from about 7 to about 24 carbon atoms; R.sub.3 is OH, OSO.sub.3.sup.-, OPO.sub.3.sup.-- or a short chain ester with from about 1 to about 6 carbon atoms.

Abstract: A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted pheynl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

Abstract: Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched diene having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkadienamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkadienamides are N-vanillyl-alkadienamides. Methods of treatment, comprising administering a safe and effective amount of these alkadienamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

Abstract: Methylenealkanamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched methylene substituted alkane having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: a methylenealkanamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these methylenealkanamides are N-vanillyl-methylenealkanamides. Methods of treatment, comprising administering a safe and effective amount of these methylenealkanamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral and topical administration.

Abstract: A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted phenyl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein n=1 or 0; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is OCH.sub.3, and wherein R.sub.2 is OH. These urea derivatives have analgesic and anti-irritant activity when administered to humans and lower animals.

Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C.sub.3 -C.sub.22 alkenyl, branched or unbranched, or benzyl; wherein R.sub.1 is H, OH or OCH.sub.3, and R.sub.2 is H or OH, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These carbamates have analgesic and anti-irritant activity when administered to humans and lower animals.

Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein R is a linear or branched C.sub.3 -C.sub.11 alkyl, alkynyl or aralkyl group, a linear or branched C.sub.3 -C.sub.22 alkenyl group, or an unbranched or branched C.sub.6 -C.sub.11 cycloalkyl or cycloalkenyl group; and wherein one of R.sub.1 and R.sub.2 is OH, the other being OH or H. These hydroxyphenylacetamides have analgesic and/or anti-irritant activity when administered either topically or systemically.

Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is ##STR2## wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is H, OH or OCH.sub.3, and wherein R.sub.2 is OH or H, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.