Abstract: A wire standoff suitable for use in a tubular reactor, such as a reformer, is described. The wire standoff includes a portion or segment positioned between an outer reactor tube and one or more reactor components located within the tube. The reactor components and the outer tube are prevented from coming into directed contact with one another by the positioning of the wire standoff. The wire standoff can be secured to a reactor component at one of its ends or to a washer located between stacked reactor components. Prevention of the reactor components from contact with the outer tube promotes fluid flow through the reactor and can enhance heat transfer and reactor efficiency for carrying out catalytic reactions.

Abstract: An energy-storing prosthetic knee includes an upper leg structure and a lower leg structure hingedly connected to the upper leg structure. The lower and upper leg structures move pivotally relative to one another. A fluid actuator is operatively connected to the upper and lower leg structures such that relative pivotal movement of the upper and lower leg structures causes a fluid to flow in a predetermined manner within the fluid actuator. At least two controllable variable fluid flow resisting devices, an accumulator, and a control system are also provided. The control system is actuable to cause storage of the fluid energy for a predetermined length of time and release of the fluid energy at a predetermined time during the gait cycle. Both the storage and release of the fluid energy are variable by action of the control system without physical modification of other components of the prosthetic knee.

Abstract: An apparatus for delivering at least one therapeutic agent to an ocular tissue of a subject includes at least one electrode, a medicament layer including the at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed, dome-shaped first and second major surfaces. The first major surface is curved such that the first major surface substantially conforms to a contour of the ocular tissue when placed in contact with the ocular tissue. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source provides a signal having certain characteristics and is electrically connected to the at least one electrode. The certain characteristics comprise at least one orienting frequency and at least one motivating frequency sufficient to motivate the at least one therapeutic agent into the ocular tissue.

Abstract: An apparatus is provided for delivering an implantable medical device to a diseased cardiac valve includes an elongated shank, a brace member, and a locking mechanism. The shank has a first end portion, a second end portion, and a first longitudinal axis extending between the end portions. The first end portion includes a rotatable annular lower support and a fixing member. The lower support includes an annular ring having oppositely disposed upper and lower surfaces and a plane extending radially between the upper and lower surfaces. The brace member includes a barrel portion operably connected to a drive system. The barrel portion includes a first end portion, a second end portion, and a second longitudinal axis extending between the end portions. The drive system includes a housing operably connected to an actuating handle. The locking mechanism is operably connected to the housing and the elongated shank.

Abstract: A reactor for carrying out catalytic reactions. The reactor includes a reactor component optionally arranged on a central rod in a reactor tube. The reactor component can have fluid ducts for directing fluid flow through the reactor. The fluid ducts are effective for increasing heat transfer in the reactor. The reactor component can further have a washer attached to a top or bottom surface for directing fluid flow.

Abstract: An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the main body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

Abstract: An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the main body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.

Abstract: Decorative textured surfaces are formed on articles having curved or contoured surfaces. A reusable, flexible textured blanket is placed in a mold along with a first material charge. A pressurizer is used to both impart the texture of the blanket to the first material charge and consolidate the charge to form a textured shell. The blanket is removed from the mold and a second material charge is introduced into the mold over the shell. The application of heat and pressure consolidates the second material charge and the shell to both form and cure the completed article.

Abstract: An apparatus for delivering at least one therapeutic agent to an ocular tissue of a subject includes at least one electrode, a medicament layer including the at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed, dome-shaped first and second major surfaces. The first major surface is curved such that the first major surface substantially conforms to the contour of the ocular tissue when placed in contact with the ocular tissue. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source provides a signal having certain characteristics and is electrically connected to the at least one electrode. The certain characteristics comprise at least one orienting frequency and at least one motivating frequency sufficient to motivate the at least one therapeutic agent into the ocular tissue.

Abstract: Decorative textured surfaces are formed on articles having curved or contoured surfaces. A reusable, flexible textured blanket is placed in a mold along with a first material charge. A pressurizer is used to both impart the texture of the blanket to the first material charge and consolidate the charge to form a textured shell. The blanket is removed from the mold and a second material charge is introduced into the mold over the shell. The application of heat and pressure consolidates the second material charge and the shell to both form and cure the completed article.

Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.

Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.

Abstract: An enzymatic hydroxylation process for the preparation of compounds useful as HMG-CoA reductase inhibitors and/or as intermediates in the preparation of HMG-CoA reductase inhibitors uses a microorganism or an enzyme derived from, or having the structure of an enzyme derived from, said microorganism, which is capable of catalyzing the hydroxylation process.

Abstract: Enzymatic hydrolysis and esterification processes for the preparation of compounds useful as HMG-CoA reductase inhibitors and/or as intermediates in the preparation of HMG-CoA reductase inhibitors.

Abstract: A protective device for a body part is formed of a pliable material and adaptable to conform to the body part to be protected. The device comprises a substantially planar member having an enlarged central portion with a depending lobe, and is adaptable to conform to and encircle at least partially a body part, the planar member having a body-facing surface and opposed exterior surface. A plurality of substantially parallel, spaced apart elongated ribs extend through the central portion and project from the exterior surface of the planar member. The planar member and ribs are formed integrally of a closed cell, cellular polymer and provided with an integrally formed, substantially nonporous, pliable skin on the exterior surface. Suitable fastening means releasably secures the device around the body part.

Abstract: A ratcheting open-ended wrench includes a fixed jaw and a pivoted jaw arranged in relationship to each other to define an in-line insertion opening aligned with the operating handle portion in accordance with a conventional open-ended wrench. The fixed and pivoted jaws are formed with cooperating notched faces creating a multiple pointed configuration equivalent to a socket or closed-end wrench for mating with a hex-type head in different angular orientation. The fixed and pivoted jaw include a force transmission arm and recess such that the turning force is transmitted from the fixed jaw directly to the pivoted jaw. The pivoted jaw has a pivoted connection to one side of the handle and extends across the end of the handle and then outwardly to locate the fulcrum permitting application of closing forces in one direction and the ratcheting release on the reverse stroke.

Abstract: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.