Patents by Inventor Brian L. Sauer

Brian L. Sauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7915037
    Abstract: The invention provides a Dre/rox recombinase system. In particular, the invention provides Dre polypeptides that can catalyze site-specific recombination at rox sites but not at lox sites. The Dre/rox system can be utilized in a number of genetic manipulations either alone or in combination with other recombinase systems.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: March 29, 2011
    Assignee: Stowers Institute for Medical Research
    Inventors: Brian L. Sauer, Jeffrey McDermott
  • Patent number: 7878208
    Abstract: Methods and systems are provided for determining a characteristic of an in vivo sensor. A transmit field, operative to induce a response signal in an associated in vivo sensor, is generated at a transmitting component having an associated orientation. The response signal is received at a receiving component, having an associated orientation. The coupling between the transmitting component and the receiving component is measured. The associated orientation of at least one of the transmitting component and the receiving component is rotated as to reduce the measured coupling.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: February 1, 2011
    Assignee: The Cleveland Clinic Foundation
    Inventors: James R. Talman, Shuvo Roy, Brian L. Sauer, Aaron J. Fleischman
  • Patent number: 7771351
    Abstract: Systems and methods are provided for determining a characteristic of an associated in vivo sensor within a living body. A transmit coil produces an excitation signal, having a first orientation, to excite the in vivo sensor to produce a response signal. A receive coil produces a current in response to the response signal. The receive coil is oriented to interact with signals having a second orientation that is substantially orthogonal to first orientation. The probe further comprises at least one eddy current compensation coil that produces a compensation field. A component of the compensation field along the second orientation has a magnitude at the receive coil substantially equal and opposite to a magnitude of a similarly oriented component of a magnetic field associated with eddy currents induced within the body.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: August 10, 2010
    Assignee: The Cleveland Clinic Foundation
    Inventors: James R. Talman, Aaron J. Fleischman, Brian L. Sauer, Shuvo Roy
  • Publication number: 20090186406
    Abstract: The invention provides a Dre/rox recombinase system. In particular, the invention provides Dre polypeptides that can catalyze site-specific recombination at rox sites but not at lox sites. The Dre/rox system can be utilized in a number of genetic manipulations either alone or in combination with other recombinase systems.
    Type: Application
    Filed: July 7, 2008
    Publication date: July 23, 2009
    Inventors: Brian L. Sauer, Jeffrey McDermott
  • Patent number: 7422889
    Abstract: The invention provides a Dre/rox recombinase system. In particular, the invention provides Dre polypeptides that can catalyze site-specific recombination at rox sites but not at lox sites. The Dre/rox system can be utilized in a number of genetic manipulations either alone or in combination with other recombinase systems.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: September 9, 2008
    Assignee: Stowers Institute for Medical Research
    Inventors: Brian L. Sauer, Jeffrey McDermott
  • Patent number: 5378618
    Abstract: This relates to an in vitro headful packaging system for cloning foreign DNA fragments as large as 95 kb. Also of concern is a method of cloning and controlling amplification of DNA fragments as large as 95 kb in a vector containing a multicopy replicon under control of a lac promoter as well as vectors useful for cloning foreign fragments of DNA as large as 95 kb and lysogens to prepare pac-cleavage proficient extract and head-tail proficient extract.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: January 3, 1995
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Nat L. Sternberg, Brian L. Sauer
  • Patent number: 4959317
    Abstract: A method for producing site-specific recombination of DNA in eukaryotic cells at regions designated lox sites is disclosed.
    Type: Grant
    Filed: April 29, 1987
    Date of Patent: September 25, 1990
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Brian L. Sauer