Patents by Inventor Brian Laundon

Brian Laundon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of cephalosporin compounds
    Patent number: 4113591
    Abstract: The invention relates to a novel method for the preparation of a 7.beta.-acylamido-3-bromomethylceph-3-em-4-carboxylic acid-1-oxide compound by brominating a 7.beta.-acylamido-3-methylceph-3-em-4-carboxylic acid-1-oxide compound.
    Type: Grant
    Filed: December 10, 1976
    Date of Patent: September 12, 1978
    Assignee: Glaxo Laboratories Limited
    Inventors: Brian Laundon, Brian Richard Cowley, David Cedric Humber
  • 7.beta.-(2-Aryl-2-hydroxyiminoacetamido)ceph-3-em-4-carboxylic acids carrying a 7.alpha.-lower alkoxy substituent
    Patent number: 4076936
    Abstract: Novel syn-7.beta.-(2-aryl-2-hydroxyiminoacetamido)ceph-3-em-4-carboxylic acids carrying a 7.alpha.-lower alkoxy substituent, particularly a 7.alpha.-methoxy group, which are broad spectrum antibiotics exhibiting low serum binding are described.
    Type: Grant
    Filed: December 1, 1976
    Date of Patent: February 28, 1978
    Assignee: Glaxo Laboratories Limited
    Inventor: Brian Laundon
  • Antibiotics
    Patent number: 4020077
    Abstract: Novel 6.beta.-isocyano penicillin and 7.beta.-isocyano cephalosporin esters of value as intermediates in the synthesis of penicillin and cephalosporin antibiotics are provided. The novel compounds may be prepared by reaction of the corresponding 6.beta.-formamido penicillin ester or 7.beta.-formamido cephalosporin ester with an acid halide derived from phosphorus, sulphur or carbon or from an oxygen acid of one of said elements, suitable halides including thionyl chloride or phosgene, or with a trivalent phosphorus compound such as triphenylphosphine and a halogenated hydrocarbon such as carbon tetrachloride. The conversion of the novel products to 6.beta.- and 7.beta.-(.alpha.-hydroxy) arylacetamido penicillins and cephalosporins respectively by reaction under acidic conditions with an aromatic aldehyde followed by treatment with an aqueous medium is also described.
    Type: Grant
    Filed: May 21, 1976
    Date of Patent: April 26, 1977
    Assignee: Glaxo Laboratories Limited
    Inventors: Martin Christopher Cook, Brian Laundon
  • Cephalosporin compounds
    Patent number: 4007174
    Abstract: Novel syn-7.beta.-(2-aryl-2-hydroxyiminoacetamido)ceph-3-em-4- carboxylic acids carrying a 7.alpha.-lower alkoxy substituent, particularly a 7.alpha.-methoxy group, which are broad spectrum antibiotics exhibiting low serum binding are described.
    Type: Grant
    Filed: July 2, 1974
    Date of Patent: February 8, 1977
    Assignee: Glaxo Laboratories Limited
    Inventor: Brian Laundon
  • 7.beta.-Isocyano cephalosporin esters and process of preparation
    Patent number: 3974150
    Abstract: Novel 6.beta.-isocyano penicillin and 7.beta.-isocyano cephalosporin esters of value as intermediates in the synthesis of penicillin and cephalosporin antibiotics are provided. The novel compounds may be prepared by reaction of the corresponding 6.beta.-formamido penicillin ester or 7.beta.-formamido cephalosporin ester with an acid halide derived from phosphorus, sulphur or carbon or from an oxygen acid of one of said elements, suitable halides including thionyl chloride or phosgene, or with a trivalent phosphorus compound such as triphenylphosphine and a halogenated hydrocarbon such as carbon tetrachloride. The conversion of the novel products to 6.beta.- and 7.beta.- (.alpha.-hydroxy) arylacetamido penicillins and cephalosporins respectively by reaction under acidic conditions with an aromatic aldehyde followed by treatment with an aqueous medium is also described.
    Type: Grant
    Filed: July 9, 1973
    Date of Patent: August 10, 1976
    Assignee: Glaxo Laboratories Limited
    Inventors: Martin Christopher Cook, Brian Laundon