Patents by Inventor Brian Leon

Brian Leon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scaleable preparation of polyketides
    Patent number: 12623988
    Abstract: Disclosed herein, inter alia, are methods of making polyketide compounds.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: May 12, 2026
    Assignee: The Regents of the University of California
    Inventors: Michael D. Burkart, Warren C. Chan, Brian Leon, James J. La Clair, Kelsey A. Trieger
  • Compositions containing, methods and uses of antibody-TLR agonist conjugates
    Patent number: 12569566
    Abstract: Disclosed herein are TLR-agonists and antibody-drug conjugates thereof. TLR agonist-antibody-drug conjugates of the disclosure comprise an antibody or an antibody fragment that can bind to HER2, and contain at least one non-natural amino acid. The TLR-agonist may be conjugated to a non-natural amino acid of the antibody via an oxime linkage. Further disclosed are methods for making and using such non-natural amino acid-containing TLR-agonists-antibody-drug conjugates, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: March 10, 2026
    Assignee: AMBRX, INC.
    Inventors: Sung-Ju Moon, Brian Leon, Mingchao Kang, Nickolas Knudsen, Jianing Wang, Sukumar Sakamuri, Feng Tian
  • ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF
    Publication number: 20230302150
    Abstract: Disclosed herein are TLR-agonists compounds, antibody-TLR agonist conjugates, pharmaceutical composition, and methods of use of such compounds or conjugates as therapeutics for treating a disease or condition such as cancer.
    Type: Application
    Filed: August 20, 2021
    Publication date: September 28, 2023
    Applicant: Ambrx, Inc.
    Inventors: Sung Ju Moon, Brian Leon, Mingchao Kang, Nickolas Knudsen, Sukumar Sakamuri, Feng Tian
  • SCALEABLE PREPARATION OF POLYKETIDES
    Publication number: 20230029301
    Abstract: Disclosed herein, inter alia, are methods of making polyketide compounds.
    Type: Application
    Filed: August 5, 2020
    Publication date: January 26, 2023
    Inventors: Michael D. Burkart, Warren C. Chan, Brian Leon, James J. La Clair, Kelsey A. Trieger
  • COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES
    Publication number: 20220226488
    Abstract: Disclosed herein are Trastuzumab-linked TLR-agonist derivative analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The Trastuzumab-linked TLR-agonist derivative analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid Trastuzumab-linked TLR-agonist derivative analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such Trastuzumab-linked TLR-agonist derivative analogs. Typically, the modified Trastuzumab-linked TLR-agonist derivative analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group.
    Type: Application
    Filed: February 12, 2020
    Publication date: July 21, 2022
    Inventors: Sung-Ju MOON, Brian LEON, Mingchao KANG, Nickolas KNUDSEN, Jianing WANG, Sukumar SAKAMURI, Feng TIAN
  • Anti-cancer and splice modulating compounds and methods
    Patent number: 11203588
    Abstract: There are provided inter alia stable anti-cancer compounds and splice modulators and methods of synthesis and use thereof.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: December 21, 2021
    Assignee: The Regents of the University of California
    Inventors: Michael D. Burkart, James J. La Clair, Sachin Dhar, Justin C. Hammons, Brian Leon