Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof. The present invention also provides biomarkers for use in determining populations for treatment with anti-PVRIG antibodies and such biomarkers include, for example PVRIG and/or PVRL2 expression.

Abstract: A method for producing a tandem sub for a perforating gun system includes positioning an electrically conductive signal bar in a central passage of a tubular housing of the tandem sub, and injecting a mold material into an annulus formed between an outer surface of the signal bar and an inner surface of the tubular housing that sealably adheres to both the signal bar and the tubular housing.

Abstract: Methods, apparatus, systems and articles of manufacture to adjust content presented to an individual are disclosed. An example system includes a first modality sensor to measure a first response of an individual to first content during a first time frame and a second modality sensor to measure a second response of the individual to the first content during the first time frame. The first modality sensor is to measure a third response of the individual to first content during a second time frame, and the second modality sensor is to measure a fourth response of the individual to the first content during the second time frame. The example system also includes a mental classifier executing instructions to determine a first mental classification of the individual based on a first comparison of the first response to a first threshold and a second comparison of the second response to a second threshold.

Abstract: A protective equipment includes a rotatable window and an extended member secured to a peripheral edge of the rotatable window. The rotatable window may be configured as a shield to be disposed between a patient and a healthcare worker to minimize exposure of the healthcare worker to at least one of the patient's bodily fluids, bacteria, and viruses. A port provides entrance by one or more instruments through the rotatable window or the extended member, thereby providing access to the patient while protecting the healthcare worker from the patient's bodily fluids, bacteria and/or viruses. The protective equipment may include an air flow system configured to receive and filter air expelled by the patient, to pull the expelled air away from the patient's face and to filter/clean the expelled air.

Abstract: A protective equipment includes a face shield configured for being worn by a patient to minimize exposure of a healthcare worker to the patient's bodily fluids, bacteria and/or viruses. The face shield includes a body having an upper peripheral edge and a lower peripheral edge. At least one port is formed in the body. The protective equipment may include a barrier positioned in the port. The protective equipment may further include an extended member secured to the lower peripheral edge of the face shield, and configured to substantially inhibit or trap micro aerosolized particles from traversing the extended member. The protective equipment includes an air flow system configured to receive and filter air from an environment external to the face shield and pull the patient's expelled air away from the patient's face and filter or clean the expelled air.

Abstract: Systems and methods for measuring biologically and behaviorally based responses to social media, locations, or experiences and providing instant and continuous feedback in response thereto are disclosed. An example system includes a first sensor to determine an emotional response of a user exposed to a social media application, a second sensor to determine a current activity of the user, and a third sensor to determine an environment of the user. The example system also establishes a priority schedule based on the emotional response, the current activity, and the environment. The system also correlates, based on the priority schedule, an advertisement with at least one of the emotional response, activity, or the environment. In addition, the example system presents the advertisement based on the priority schedule and the correlation of the advertisement with the at least one of the activity, the environment, or the emotional response.

Abstract: A system for a healthcare provider to administer a portable interactive hearing assessment is provided. The system allows the healthcare provider to administer the hearing assessment in a way that accurately detects hearing loss and provides recommendations for seeking further assistance from qualified hearing health specialists and/or an ENT physician. The system includes a hearing test device, and a processor that receives and processes a pressure test result associated with each of the patient's ear from a tympanometer and the patient's response to one or more pure tone frequencies transmitted by the hearing test device. The processor may also provide a report and recommendation based on received pressure test result and the determined hearing results, and demonstrate effects of any hearing loss to a person accompanying the patient so that the accompanying person understands a scope of the patient's hearing loss.

Abstract: The present invention is directed to a method and system for predicting the behavior of an audience based on the biologically based responses of the audience to a presentation that provides a sensory stimulating experience and determining a measure of the level and pattern of engagement of that audience to the presentation. In particular, the invention is directed to a method and system for predicting whether an audience is likely to view a presentation in its entirety. In addition, the present invention may be used to determine the point at which an audience is likely to change their attention to an alternative sensory stimulating experience including fast forwarding through recorded content, changing the channel or leaving the room when viewing live content, or otherwise redirecting their engagement from the sensory stimulating experience.

Abstract: Systems and methods for measuring biologically and behaviorally based responses to social media, locations, or experiences and providing instant and continuous feedback in response thereto are disclosed. An example system includes a first sensor to determine an emotional response of a user exposed to a social media application, a second sensor to determine a current activity of the user, and a third sensor to determine an environment of the user. The example system also establishes a priority schedule based on the emotional response, the current activity, and the environment. The system also correlates, based on the priority schedule, an advertisement with at least one of the emotional response, activity, or the environment. In addition, the example system presents the advertisement based on the priority schedule and the correlation of the advertisement with the at least one of the activity, the environment, or the emotional response.

Abstract: Methods, apparatus, systems and articles of manufacture to adjust content presented to an individual are disclosed. An example system includes a first modality sensor to measure a first response of an individual to first content during a first time frame and a second modality sensor to measure a second response of the individual to the first content during the first time frame. The first modality sensor is to measure a third response of the individual to first content during a second time frame, and the second modality sensor is to measure a fourth response of the individual to the first content during the second time frame. The example system also includes a mental classifier executing instructions to determine a first mental classification of the individual based on a first comparison of the first response to a first threshold and a second comparison of the second response to a second threshold.

Abstract: The present invention is directed to a method and system for predicting the behavior of an audience based on the biologically based responses of the audience to a presentation that provides a sensory stimulating experience and determining a measure of the level and pattern of engagement of that audience to the presentation. In particular, the invention is directed to a method and system for predicting whether an audience is likely to view a presentation in its entirety. In addition, the present invention may be used to determine the point at which an audience is likely to change their attention to an alternative sensory stimulating experience including fast forwarding through recorded content, changing the channel or leaving the room when viewing live content, or otherwise redirecting their engagement from the sensory stimulating experience.

Abstract: A system that enables a hearing test administrator to reduce false indications of hearing loss in a patient and administer an interactive hearing assessment in a test environment is described. The system includes a sound measuring device to measure one or more background sounds of the test environment, and a data processor to process the background sounds, and determine the frequency and amplitude of the background sounds. The system may further include a memory that stores the backgrounds sounds, and its frequency and/or amplitude. The system may analyze whether the background sounds are above the maximum permissible ambient noise levels of the test environment and generate a report for analysis by the hearing test administrator.

Abstract: Methods, apparatus, systems and articles of manufacture to adjust content presented to an individual are disclosed. An example system includes a first modality sensor to measure a first response of an individual to first content during a first time frame and a second modality sensor to measure a second response of the individual to the first content during the first time frame. The first modality sensor is to measure a third response of the individual to first content during a second time frame, and the second modality sensor is to measure a fourth response of the individual to the first content during the second time frame. The example system also includes a mental classifier executing instructions to determine a first mental classification of the individual based on a first comparison of the first response to a first threshold and a second comparison of the second response to a second threshold.

Abstract: A system and a method for a healthcare provider to easily, accurately and efficiently provide a diagnostic hearing assessment, for their patients, in a way that accurately detects hearing loss and provides recommendations for seeking further assistance from remotely-located ear specialists is provided.

Abstract: The present invention is directed to a method and system for predicting the behavior of an audience based on the biologically based responses of the audience to a presentation that provides a sensory stimulating experience and determining a measure of the level and pattern of engagement of that audience to the presentation. In particular, the invention is directed to a method and system for predicting whether an audience is likely to view a presentation in its entirety. In addition, the present invention may be used to determine the point at which an audience is likely to change their attention to an alternative sensory stimulating experience including fast forwarding through recorded content, changing the channel or leaving the room when viewing live content, or otherwise redirecting their engagement from the sensory stimulating experience.

Abstract: The present invention is directed to a method and system for predicting the behavior of an audience based on the biologically based responses of the audience to a presentation that provides a sensory stimulating experience and determining a measure of the level and pattern of engagement of that audience to the presentation. In particular, the invention is directed to a method and system for predicting whether an audience is likely to view a presentation in its entirety. In addition, the present invention may be used to determine the point at which an audience is likely to change their attention to an alternative sensory stimulating experience including fast forwarding through recorded content, changing the channel or leaving the room when viewing live content, or otherwise redirecting their engagement from the sensory stimulating experience.

Abstract: Methods, apparatus, systems and articles of manufacture to adjust content presented to an individual are disclosed. An example system includes a first modality sensor to measure a first response of an individual to first content during a first time frame and a second modality sensor to measure a second response of the individual to the first content during the first time frame. The first modality sensor is to measure a third response of the individual to first content during a second time frame, and the second modality sensor is to measure a fourth response of the individual to the first content during the second time frame. The example system also includes a mental classifier executing instructions to determine a first mental classification of the individual based on a first comparison of the first response to a first threshold and a second comparison of the second response to a second threshold.

Abstract: Methods, apparatus, systems and articles of manufacture to adjust content presented to an individual are disclosed.

Abstract: A system for a healthcare provider to administer a portable interactive hearing assessment is provided. The system allows the healthcare provider to administer the hearing assessment in a way that accurately detects hearing loss and provides recommendations for seeking further assistance from qualified hearing health specialists and/or an ENT physician. The system includes a hearing test device, and a processor that receives and processes a pressure test result associated with each of the patient's ear from a tympanometer and the patient's response to one or more pure tone frequencies transmitted by the hearing test device. The processor may also provide a report and recommendation based on received pressure test result and the determined hearing results, and demonstrate effects of any hearing loss to a person accompanying the patient so that the accompanying person understands a scope of the patient's hearing loss.

Abstract: A system and a method for a healthcare provider to easily, accurately and efficiently provide a hearing test and a pressure test, i.e., a hearing assessment, for their patients, in a way that accurately detects hearing loss and provides recommendations for seeking further assistance from qualified hearing health specialists is provided.