Abstract: A rearview device including a housing, a bezel and a rearview element used for vehicles. In one embodiment the bezel includes a transparent or chrome-based coating as to allow one or more lighting assemblies positioned in or beneath the bezel to illuminate the surrounding and provide different functions to the driver or other persons. For example, different indicator functions can be provided. Different electronic means may be placed in or beneath the bezel to optimize the used space inside the rearview device.

Abstract: A device for cleaning at least one optical surface of at least one camera, a camera system and a camera holder including such a device and a method of using the device, the camera system and/or the camera holder.

Abstract: The invention relates, in part, to systems and methods for scoring a sample containing tumor tissue from a cancer patient. The score is representative of a nearness between at least one pair of cells, a first member of the least one pair of cells expressing a first biomarker and a second member of the at least one pair of cells expressing a second biomarker that is different from the first biomarker. The score obtained from these methods can be indicative of a likelihood that a patient may respond positively to immunotherapy.

Abstract: The invention relates, in part, to methods of scoring a sample containing tumor tissue from a cancer patient. The score is representative of a spatial proximity between at least one pair of cells, a first member of the at least one pair of cells expressing a first biomarker and a second member of the at least one pair of cells expressing a second biomarker that is different from the first biomarker. The score obtained from these methods can be indicative of a likelihood that a patient may respond positively to immunotherapy.

Abstract: The invention relates, in part, to systems and methods for scoring a sample containing tumor tissue from a cancer patient. The score obtained from these methods can be indicative of a likelihood that a patient may respond positively to immunotherapy. The invention also relates, in part, to methods of deriving a value for % biomarker positivity (PBP) for all cells or optionally, one or more subsets thereof, present in a field of view of a tissue sample from a cancer patient. The values for PBP can be indicative of a patient's response to immunotherapy.

Abstract: A multifunction lamp unit for a vehicle includes a housing, at least one light pipe together with at least one light source disposed at least partially within the housing, and a clear lens substantially enclosing the housing, the at least one light pipe and the at least one light source, the lens having an inner surface, an outer surface disposed opposite the inner surface and at least one of a continuous transparent and translucent coating on the outer surface.

Abstract: A rear view assembly for a rear view device of a vehicle includes a rear view element, a carrier plate for the rear view element, and a heating and lighting unit arranged between the rear view element and the carrier plate. The heating and lighting unit may include a light module including a printed circuit board having at least one LED and having no power stripes, and a heater pad. The heater pad may include a circuit or printed circuit board, at least one recess or at least one transparent window, and first contacts or contact elements for contacting a printed circuit board of the light module.

Abstract: The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the ClC-1 ion channel. The compounds include phenoxy propanoic acid, phenoxy propanoate, and phenoxy butanoate compounds.

Abstract: The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel.

Abstract: A light guiding device for an illumination device, especially for a motor vehicle or an indicator device in a rearview device of a motor vehicle includes a light coupling side for incoupling light from a light source, a reflection side having a reflection layer; and a light outcoupling side, which is disposed generally opposite the reflection side. A clearance between the reflection side and the light outcoupling side generally decreases as the distance from the light incoupling side increases. The reflection side having the reflection layer is configured so that light arriving from the light incoupling side is deflected to the light outcoupling side. The reflection layer may be a paint or lacquer layer that is imprinted or evaporation-coated on the reflection side; and the having a white sheet on or next to the rejection side.

Abstract: The present invention relates to a polymeric substrate being coated with a reflective coating, particularly a chromium-based reflective coating.

Abstract: A light guiding device for an illumination device, especially for a motor vehicle or an indicator device in a rearview device of a motor vehicle includes a light coupling side for incoupling light from a light source, a reflection side having a reflection layer; and a light outcoupling side, which is disposed generally opposite the reflection side. A clearance between the reflection side and the light outcoupling side generally decreases as the distance from the light incoupling side increases. The reflection side having the reflection layer is configured so that light arriving from the light incoupling side is deflected to the light outcoupling side. The reflection layer may be a paint or lacquer layer that is imprinted or evaporation-coated on the reflection side; and the having a white sheet on or next to the rejection side.

Abstract: Y4 receptor agonist peptide selected from the group consisting of: [Ala30]PP2-36, [Thr30]PP2-36, [Asn30]PP2-36, [Gln30]PP2-36, [Glu10]PP2-36, [Glu10,Leu17,Thr30]PP2-36, [Nle17,Nle30]PP2-36, [Glu10,Nle17,Nle30]PP2-36, their PP1-36 equivalents, and analogues and derivatives thereof as described in the specification, are selective agonists of the Y4 receptor relative to the Y1 and Y2 receptors, and are useful in the treatment, for example, of obesity and overweight, and conditions in which these are considered contributory factors, and in the treatment of diarrhoea and intestinal hypersecretion.

Abstract: Human Pancreatic Polypeptide mutants are provided which have utility, inter alia, for regulation of energy intake or energy metabolism, control of intestinal secretion, decrease of gastrointestinal tract motility, decrease of rate of gastric emptying, treatment of obesity or overweight, or conditions in which obesity or overweight is a contributory factor.

Abstract: Y4 receptor agonist peptide selected from the group consisting of: [Ala30]PP2-36, [Thr30]PP2-36, Asn30]PP2-36, [Gln30]PP2-36, [Glu10]PP2-36, [Glu10,Leu17,Thr30]PP2-36, [Nle17,Nle30]PP2-36, [Glu10,Nle17,Nle30]PP2-36, their PP1-36 equivalents, and analogues and derivatives thereof as described in the specification, are selective agonists of the Y4 receptor relative to the Y1 and Y2 receptors, and are useful in the treatment, for example, of obesity and overweight, and conditions in which these are considered contributory factors, and in the treatment of diarrhoea and intestinal hypersecretion.

Abstract: A method of evaluating the quality management characteristics of a business is disclosed. The method includes identification of criteria for evaluating the business, said criteria comprising one or more of customer focus, leadership, involvement of people, process approach, system approach to management, continual improvement, factual approach to decision making, and mutually beneficial supplier relationships; providing a quantitative grade for each of the identified criteria; evaluating the quantitative grade for each of the identified criteria; and providing an output of favorable or unfavorable evaluation results based upon evaluating the quantitative grade for each identified criteria.