Patents by Inventor Brian M. Beyer

Brian M. Beyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED ANTI-IL-23 ANTIBODIES
    Publication number: 20090156788
    Abstract: Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
    Type: Application
    Filed: February 13, 2009
    Publication date: June 18, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Leonard G. Presta, Brian M. Beyer, Richard N. Ingram, Peter Orth, Yan-Hui Liu
  • Methods for identifying modified tumor necrosis factor-alpha converting enzyme inhibitors
    Patent number: 7529628
    Abstract: The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In addition, the present invention discloses methods of using the proteins, crystals and/or three-dimensional structures obtained to identify compounds that can modulate the enzymatic activity of TACE.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: May 5, 2009
    Assignee: Schering Corporation
    Inventors: Brian M. Beyer, Richard N. Ingram, Peter Orth, Corey O. Strickland
  • Codon-optimized ?-secretase and methods of refolding and processing
    Patent number: 7166454
    Abstract: The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of ?-secretase (BACE) polypeptide. Polypeptides used herein are derived from human BACE which is also known by the synonyms “mamapsin 2”, “human ?-site APP-cleaving enzyme, and Asp2”. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: January 23, 2007
    Assignee: Schering Corporation
    Inventors: Brian M. Beyer, Bruce A. Malcolm, Corey O. Strickland, Wenyan Wang, Eileen Wilson
  • Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof
    Patent number: 7138264
    Abstract: The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In addition, the present invention discloses methods of using the proteins, crystals and/or three-dimensional structures obtained to identify compounds that can modulate the enzymatic activity of TACE.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: November 21, 2006
    Assignee: Schering Corporation
    Inventors: Brian M. Beyer, Richard N. Ingram, Peter Orth, Corey Strickland
  • Beta-secretase crystals and methods for preparing and using the same
    Publication number: 20040014194
    Abstract: The present invention relates to the expression, purification and crystallization of glycosylated &bgr;-secretase protein and a complex thereof. The crystals of the invention are useful, inter alia, for determining the three-dimensional structure of &bgr;-secretase and of other, related proteins.
    Type: Application
    Filed: March 26, 2003
    Publication date: January 22, 2004
    Applicant: Schering Corporation
    Inventors: Brian M. Beyer, Gerald S. Hammond, Paul Reichert, Corey Strickland, Wenyan Wang, Patricia C. Weber, Gwendolyn Tse Wong, Lili Zhang
  • Peptide substrates for HCV NS3 protease assays
    Patent number: 6251583
    Abstract: Novel chromogenic, fluorogenic and fluorescence polarization substrates which are useful in HCV NS3 protease and inhibitor assays.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: June 26, 2001
    Assignee: Schering Corporation
    Inventors: Rumin Zhang, Bruce A. Malcolm, Brian M. Beyer, F. George Njoroge, James P. Durkin, William T. Windsor