Abstract: A system includes a computing device comprising a memory storing instructions configured to cause a processor to receive: purchase data associated with products purchased by a user, online activity data performed by the user and other users and associated with information pertaining to the products, and vendor information comprising retail sales data, after-market sales data, and product availability associated with the products. The processor determines one or more values of the products based on the purchase data, the online activity data, and the vendor information and whether the purchased products correspond to specialty products based on the purchase data, the online activity data, and the values of the products. The processor may then send a notification to the user comprising an offer for insurance for the products in response to determining the products correspond to specialty products.

Abstract: The present invention relates to metalloprotease enzymes isolated from scorpion venom, their nucleic acid and amino acid sequences, and methods of use thereof in the treatment of various diseases, disorders and cosmetic conditions.

Abstract: The present invention is a device that combines the attributes of a standard push broom used to sweep up various residue in a garage, store, sidewalk, or industrial setting with the attributes of a specialized push broom designed to attract and pick up ferrous metals.

Abstract: The present invention relates to metalloprotease enzymes isolated from scorpion venom, their nucleic acid and amino acid sequences, and methods of use thereof in the treatment of various diseases, disorders and cosmetic conditions.

Abstract: The present invention provides the discovery and isolation of the nucleotide sequence of the human clk2, the human propin1, and the human cote1 genes that are located within the glucocerebrosidase gene locus. Also provided by the present invention are proteins or polypeptides encoded by those genes, nucleic acids encoding those polypeptides, and antibodies to those proteins. Further provided by the present invention are nucleic acids of the same apparent molecular size as the propin1 and cote1 gene regions and which have the same restriction pattern as the wild-type genes.

Abstract: Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.

Abstract: Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.

Abstract: A major heat-stable shrimp allergen is characterized as a 34 kDa protein corresponding to shrimp tropomyosin. Two IgE binding epitopes of this allergen have the sequences FLAEEADRK (SEQ ID NO: 1) and MQQLENDLDQVQESLLK (SEQ ID NO: 2), respectively. Surprisingly, both antigenic and allergenic activities of the allergen were found to be associated with these two peptide fractions. A-a-id antibodies recognized this allergen as well as a homologous 34 kDa allergen from lobster, prawn and crab, indicating that these antibodies recognize major cross-reacting IgE binding epitopes common to crustacea. The two epitopes are useful in the diagnosis and/or treatment of allergies, particularly in the desensitization of individuals that are allergic to shrimp and other crustacea. Variants and subfragments of the two epitopes display allergenicity, as assessed by reaction with allergen-specific IgE obtained from shrimp-sensitive patients.

Abstract: A seat belt buckle 10, adapted to releasably engage with a latch plate 24 insertable within a latch passage 22 in the seat belt buckle 10, comprises: a rigid frame 12 having an open forward end 11 defining the latch passage 22, an opposite rearward end 13 adapted to be attached to a seat belt, an apertured rectangular base plate 14, an upstanding side wall 16 extending from each longitudinal edge of the base plate 14, and a fixed bar 18 extending across the width of the base plate 14 between the forward and rearward ends thereof, parallel to, and spaced apart from, the base plate 14, the fixed bar 18 being secured at each end thereof to a respective side wall 16.

Abstract: A seat belt buckle 10, having a pivoted locking member 26 adapted to releasably engage with a cross-bar 34 of an apertured latch plate 24 insertable within a latch passage 22 in the seat belt buckle, includes a rigid frame 12 having an apertured rectangular base plate 14, upstanding side walls 16 extending from longitudinal edges of the base plate 14, and a fixed bar 18 extending across the width of the base plate 14, parallel to, and spaced apart from, the base plate, the fixed bar 18 being secured at each end thereof to a respective side wall 16.