Abstract: The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, or a tautomer thereof, or a hydrate thereof.

Abstract: Air-buoyant structures, and vehicles incorporating air-buoyant structures, are provided. Hollow, air-buoyant structures may include a shell of ultra-low density aerogel material, foam material, or vapor-expanded material that is strong and stiff enough to withstand atmospheric pressure and lightweight enough to achieve buoyancy in air under evacuation. The shell may be reinforced with a suitable reinforcing material, such as helical nanofibers. The air-buoyant structures may also include vacuum pumps and valves operably connected to or integrated with the hollow shell. The vacuum pumps and valves may be configured to pump air out of the hollow shell and allow air back into the hollow shell to control buoyancy.

Abstract: A method for forming a photon absorbing layer. A substrate having a target surface is introduced into a controllable environment, and the pressure within the controllable environment is reduced. A first flux of a semiconductor material and a second flux of a dopant are simultaneously directed toward the target surface for a period of time, thereby producing a thickness of a substantially amorphous layer of the semiconductor material and dopant on the target surface. The semiconductor layer is laser annealed to convert it to a substantially multi-crystalline layer.

Abstract: A system and method for supporting a patient gas delivery tube includes an elongated support member having first and second distal end and a living hinge biasing arcuate movement between the distal ends. A generally planar, rigid base configured to secures a lower distal end so that the support member extends from a surface of the base. A mount secured to the other distal end is adapted to secure an associated tube.

Abstract: R.F. sputtered nickel in silica films containing 64 to 70 atomic percent nickel are employed as electrical resistance elements in a resistance thermometer for measuring temperatures of 50.degree. K and less.