Patents by Inventor Brian M. Stoltz

Brian M. Stoltz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11866398
    Abstract: This invention relates generally to the synthesis of ?12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. ?12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: January 9, 2024
    Assignee: California Institute of Technology
    Inventors: Jiaming Li, Xu Chen, Tonia S. Ahmed, Brian M. Stoltz, Robert H. Grubbs
  • Patent number: 11845770
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: December 19, 2023
    Assignees: California Institute of Technology, Holoclara, Inc.
    Inventors: Brian M. Stoltz, Corey M. Reeves, Eduardo J. Martinez, Simon Bailey
  • Patent number: 11753421
    Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: September 12, 2023
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • Publication number: 20230135574
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).
    Type: Application
    Filed: October 21, 2022
    Publication date: May 4, 2023
    Inventors: Brian M. Stoltz, Corey M. Reeves, Eduardo J. Martinez, Simon Bailey
  • Publication number: 20230116602
    Abstract: The present disclosure provides compounds, such as compounds of Formula I, and compositions that are MCL1 inhibitors.
    Type: Application
    Filed: October 2, 2020
    Publication date: April 13, 2023
    Inventors: Brendan M. O' Boyle, Emma L. Baker-Tripp, Corey M. Reeves, Kevin C. Yang, Tristin E. Rose, Justin A. Hilf, Brian M. Stoltz, Michael D. Bartberger, Oliver C. Loson, Martina S. McDermott, Neil A. O'Brien, Dennis Slamon
  • Publication number: 20230098847
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Application
    Filed: July 18, 2022
    Publication date: March 30, 2023
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • Publication number: 20230057900
    Abstract: The present disclosure provides methods of collecting electron diffraction patterns from nanocrystals to obtain a three-dimensional structural model of a compound, as well as methods of identifying compounds and methods of determining polymorphic forms. In addition, the present disclosure provides methods of characterizing a first compound from a sample, as well as methods of screening compounds from a sample. The present disclosure also provides systems for characterizing a compound from a sample, which systems include modules for high-performance liquid chromatography, dispensing, and electron microscopy.
    Type: Application
    Filed: September 10, 2020
    Publication date: February 23, 2023
    Inventors: Hosea M. Nelson, Jose A. Rodriguez, Brian M. Stoltz
  • Publication number: 20220235086
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).
    Type: Application
    Filed: May 15, 2020
    Publication date: July 28, 2022
    Inventors: Brian M. Stoltz, Corey M. Reeves, Eduardo J. Martinez, Simon Bailey
  • Publication number: 20220227738
    Abstract: The invention relates to compounds of Formula I, and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds of the invention are effective in inhibiting KRAS protein with a G12C mutation and are suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 21, 2022
    Inventors: Justin A. Hilf, Tristin E Rose, Michael D. Bartberger, Brendan M. O'Boyle, Corey M. Reeves, Oliver C. Loson, Brian M. Stoltz, Martina S. McDermott, Neil A. O'Brien, Dennis Slamon
  • Patent number: 11390585
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: July 19, 2022
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • Publication number: 20220213081
    Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of ?-substituted lactams, such as ?-lactams. The use of various electrophiles and ligands are described, and result in the construction of ?-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
    Type: Application
    Filed: December 31, 2021
    Publication date: July 7, 2022
    Inventors: Brian M. Stoltz, Alexander W. Sun, Stephan N. Hess, Carina I. Jette, Irina Geibel, Shoshana Bachman, Masaki Hayashi, Hideki Shimizu, Jeremy B. Morgan, Shunya Sakurai, Zachary P. Sercel
  • Patent number: 11377396
    Abstract: This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: July 5, 2022
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Yoshitaka Numajiri, Beau P. Pritchett, Koji Chiyoda
  • Publication number: 20220194949
    Abstract: The present disclosure describes compounds of formulas (I)-(V) and methods of making the same. The compounds of the present disclosure are useful as inhibitors of PRMT5 activity and in methods of treating cancers and other diseases.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 23, 2022
    Inventors: Brendan M. O'Boyle, Corey M. Reeves, Justin A. Hilf, Brian M. Stoltz, Michael D. Bartberger, Steven J. Wittenberger, Oliver C. Loson, Martina S. McDermott, Neil A. O'Brien, Dennis Slamon
  • Publication number: 20220185828
    Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
    Type: Application
    Filed: March 7, 2022
    Publication date: June 16, 2022
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • Patent number: 11312733
    Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: April 26, 2022
    Assignee: California Institute of Technology
    Inventors: Anton Toutov, Kerry Betz, Alexey Fedorov, Brian M. Stoltz, Wenbo Liu, Robert H. Grubbs
  • Publication number: 20220119377
    Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of ?-substituted lactams, such as ?-lactams. The use of various electrophiles and ligands are described, and result in the construction of ?-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
    Type: Application
    Filed: December 31, 2021
    Publication date: April 21, 2022
    Inventors: Brian M. Stoltz, Alexander W. Sun, Stephan N. Hess, Carina I. Jette, Irina Geibel, Shoshana Bachman, Masaki Hayashi, Hideki Shimizu, Jeremy B. Morgan, Shunya Sakurai, Zachary P. Sercel
  • Publication number: 20220106325
    Abstract: The present disclosure provides compounds and compositions that are CDK inhibitors selective for CDK4 and/or CDK6, and methods of use thereof.
    Type: Application
    Filed: July 26, 2019
    Publication date: April 7, 2022
    Inventors: Brendan M. O'Boyle, Justin A. Hilf, Scott C. Virgil, Alexander W. Sun, Brian M. Stoltz, Dylan Conklin, Martina S. McDermott, Neil A. O'Brien, Michael J. Palazzolo, Dennis Slamon, Michael D. Bartberger
  • Publication number: 20220002294
    Abstract: The present disclosure provides compounds and compositions that are inhibitors of ERK1, ERK2, or both, and methods of use thereof.
    Type: Application
    Filed: November 15, 2019
    Publication date: January 6, 2022
    Inventors: Corey M. Reeves, Brandan M. O'Boyle, Justin A. Hilf, Dylan Conklin, Martina S. McDermott, Neil A. O'Brien, Michael J. Palazzolo, Dennis Slamon, Steven J. Wittenberger, Oliver C. Loson, Michael D. Bartberger, Brian M. Stoltz
  • Patent number: 11214568
    Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of ?-substituted lactams, such as ?-lactams. The use of various electrophiles and ligands are described, and result in the construction of ?-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: January 4, 2022
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Alexander W. Sun, Stephan N. Hess, Carina I. Jette, Irina Geibel, Shoshana Bachman, Masaki Hayashi, Hideki Shimizu, Jeremy B. Morgan, Shunya Sakurai, Zachary P. Sercel
  • Publication number: 20210323983
    Abstract: The present disclosure is directed to methods of silylating organic substrates containing C—H or O—H bonds. In some embodiments, the methods use compositions that are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide, metal alkoxide, metal silanoates, potassium amides, and/or graphitic potassium bases.
    Type: Application
    Filed: May 27, 2021
    Publication date: October 21, 2021
    Inventors: Anton Toutov, Wenbo Liu, David P. Schuman, Brian M. Stoltz, Robert H. Grubbs