Abstract: The disclosure relates generally to molecular diagnostic devices configured to amplifying a single nucleotide polymorphism (SNP) locus and discriminate between two or more allelic variants of the SNP, indicating presence or absence of a target allele. In some embodiments, the molecular diagnostic devices are capable of detecting, at point-of-care, SNPs associated with resistance or susceptibility to antibiotic treatment of organism infections. In other aspects, the disclosure provides methods of treatment for disease or disorders (e.g. organism infections) where treatment is guided by presence or absence of an allele at a SNP locus as determined by such molecular diagnostic devices.

Abstract: The present disclosure provides a flexible container (10). In an embodiment, the flexible container includes a front panel (22), a rear panel (24), a first gusseted side panel (18), and a second gusseted side panel (20). The gusseted side panels adjoin the front panel and the rear panel along peripheral seals (41) to form a chamber. The panels form (i) a top portion, (ii) a body portion, and (iii) a bottom portion. The top portion comprises a neck (27) and a fitment (30) in the neck. The front panel comprises a front handle (82) extending therefrom and the rear panel comprises a rear handle (84) extending therefrom. The front handle and the rear handle are in opposing relation to each other, the front handle and the rear handle extending over the first gusseted side panel.

Abstract: A device for accommodating and magnetizing a tissue-penetrating medical device of various lengths, with or without a cover covering a portion or the entirety of the tissue-penetrating medical device, is disclosed including a sleeve member having an open proximal end, a distal end, an inner surface, an outer surface having a graduated injection depth gauge to indicate needle penetration depth when the cover is placed into a magnetizer, and a hollow body extending between the proximal end and the distal end to form a protective closure over a shaft of a tissue-penetrating medical device. A device having one or more magnetizing elements sectioned into a plurality of movable segments pivoting around an axis to accommodate needles with different lengths is also disclosed. Also disclosed is a device having one or more magnetizing means mounted on a movable element to magnetize needles of various lengths.

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: A work light including a body defining a first end, a second end opposite the first end, a length extending between the first end and the second end, and a pivot axis extending parallel to the length. The first end includes a power button. The work light further includes a light source head pivotally coupled to the body to pivot about the pivot axis and configured to be operated by the power button. The light source head includes a planar light panel having a plurality of light emitting diodes aligned in a direction parallel to the pivot axis. The work light further includes a battery receptacle disposed on the body and configured to receive at least a portion of a battery. The battery couples to the battery receptacle by sliding into the battery receptacle along the direction parallel to the pivot axis.

Abstract: A method and apparatus are disclosed for a reinforced steerable sheath assembly that is usable with an actuator comprising a shaft section defining a sheath that is operable to be deflected, and one or more pull wires that are coupled to the sheath via a coupling at a point of contact between the pull wires and the sheath. The pull wires being operable to be coupled to the actuator for actuating the pull wires. The reinforced steerable sheath assembly further comprises a means for preventing displacement of the coupling, wherein the means for preventing displacement to minimize failure at the coupling at the point of contact between the pull wires and the sheath upon actuation of the pull wires upon actuation of the actuator to deflect the sheath.

Abstract: A method and apparatus are disclosed for a reinforced steerable sheath assembly that is usable with an actuator comprising a shaft section defining a sheath that is operable to be deflected, and one or more pull wires that are coupled to the sheath via a coupling at a point of contact between the pull wires and the sheath. The pull wires being operable to be coupled to the actuator for actuating the pull wires. The reinforced steerable sheath assembly further comprises a means for preventing displacement of the coupling, wherein the means for preventing displacement to minimize failure at the coupling at the point of contact between the pull wires and the sheath upon actuation of the pull wires upon actuation of the actuator to deflect the sheath.

Abstract: The present invention relates to bodysuits for use as personal protective equipment comprising a torso portion comprising a front side; a back side including a sealable port through which a wearer can enter and exit the bodysuit when donning or doffing the bodysuit, respectively; a waist region; a neck opening; a pair of upper limb openings; and a pair of lower limb openings; two arm portions each extending from one of the upper limb opening; and two leg portions each extending from one of the lower limb opening and methods for the removal of such body suits.

Abstract: A method and apparatus are disclosed for a modified tip for a sheath assembly that provides enhanced radiopacity while maintaining the distal tip profile to maintain adequate tip stiffness and tip transition force. The disclosed method and apparatus provide a distal tip segment for a sheath assembly comprising a region of increased wall thickness along a portion or section of the distal tip segment, providing increased cross-sectional area there-along to provide enhanced radiopacity, and a distal most section of the distal tip segment having a reduced or minimal profile to provide an atraumatic tip while maintaining sufficient stiffness for crossability. The distal tip segment is operable to be coupled to a proximal shaft portion of the sheath assembly, to provide enhanced radiopacity while maintaining the distal tip profile to maintain adequate tip stiffness.

Abstract: The present invention relates to bodysuits for use as personal protective equipment comprising a torso portion comprising a front side; a back side including a sealable port through which a wearer can enter and exit the bodysuit when donning or doffing the bodysuit, respectively; a waist region; a neck opening; a pair of upper limb openings; and a pair of lower limb openings; two arm portions each extending from one of the upper limb opening; and two leg portions each extending from one of the lower limb opening and methods for the removal of such body suits.

Abstract: Disclosed are various embodiments for a power stage that can drive various types of loads. The power stage includes a first capacitor and a second capacitor that are coupled to the load. The power stage also includes switches that are operable in a first power stage state and a second power stage state. When the switches are in the first power stage state, the first capacitor discharges to the load, and the second capacitor charges. When the switches are in the second power stage state, the second capacitor discharges to the load, and the first capacitor charges.

Abstract: Disclosed are various embodiments for a power stage that can drive various types of loads. The power stage includes a first capacitor and a second capacitor that are coupled to the load. The power stage also includes switches that are operable in a first power stage state and a second power stage state. When the switches are in the first power stage state, the first capacitor discharges to the load, and the second capacitor charges. When the switches are in the second power stage state, the second capacitor discharges to the load, and the first capacitor charges.

Abstract: A facility procuring information about a distinguished property from a user knowledgeable about the distinguished property that is usable to refine an automatic valuation of the distinguished property is described. The facility displays information about the distinguished property used in the automatic valuation of the distinguished property. The facility obtains user input from of the user adjusting at least one aspect of information about the distinguished property used in the automatic valuation of the distinguished property. On a later the day, facility displays to the user a refined valuation of the distinguished property that is based on the adjustment of the obtained user input.