Patents by Inventor Brian MacConaghy
Brian MacConaghy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210325280Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.Type: ApplicationFiled: April 23, 2021Publication date: October 21, 2021Inventors: Thomas J. Matula, Karol Bomsztyk, Brian MacConaghy, Justin Reed, Adam D. Maxwell
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Patent number: 10794827Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.Type: GrantFiled: April 4, 2017Date of Patent: October 6, 2020Assignee: UNIVERSITY OF WASHINGTONInventors: Thomas Matula, Andrew A. Brayman, Oleg A. Sapozhnikov, Brian MacConaghy, Jarred Egan Swalwell, Camilo Perez
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Publication number: 20190282201Abstract: A stylet includes a handle assembly with an indicator display and a stiff wire assembly extending distally from the handle assembly having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser, a transmit/receive chip, a bandpass filter, a differential amplifier, an ADC, and an MCU, operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.Type: ApplicationFiled: October 17, 2018Publication date: September 19, 2019Applicant: University of Washington through its Center for CommercializationInventors: Pierre D. Mourad, Samuel R. Browd, Brian MacConaghy, Revathi Murthy, Nathaniel Coulson
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Patent number: 10123766Abstract: A stylet (100) includes a handle assembly (102) with an indicator display (112) and a stiff wire assembly (120) extending distally from the handle assembly (102) having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser (120), a transmit/receive chip (132), a bandpass filter (134), a differential amplifier (136), an ADC (138), and an MCU (140), operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.Type: GrantFiled: December 10, 2012Date of Patent: November 13, 2018Assignee: University of Washington Through its Center for CommercializationInventors: Pierre D. Mourad, Samuel R. Browd, Brian MacConaghy, Revathi Murthy, Nathaniel Coulson
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Publication number: 20170328834Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.Type: ApplicationFiled: April 4, 2017Publication date: November 16, 2017Applicant: University of WashingtonInventors: Thomas Matula, Andrew A. Brayman, Oleg A. Sapozhnikov, Brian MacConaghy, Jarred Egan Swalwell, Camilo Perez
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Publication number: 20170205318Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.Type: ApplicationFiled: July 14, 2015Publication date: July 20, 2017Applicant: University of WashingtonInventors: Thomas J. Matula, Karol Bomsztyk, Brian MacConaghy, Justin Reed, Adam D. Maxwell
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Patent number: 9645080Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.Type: GrantFiled: April 16, 2014Date of Patent: May 9, 2017Assignee: University of WashingtonInventors: Thomas Matula, Andrew A. Brayman, Oleg A. Sapozhnikov, Brian MacConaghy, Jarred Egan Swalwell, Camilo Perez
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Publication number: 20150251141Abstract: Described herein are apparatuses and methods for preventing or otherwise reducing scaling and fouling of a membrane using ultrasonic vibrations. One example method involves: (1) directing a solution to a membrane of a membrane assembly, where the membrane passes a solvent of the solution through the membrane at a first rate, and where the membrane prevents at least some of a solute of the solution from passing through the membrane; and (2) causing a piezoelectric material that is physically coupled to the membrane to produce ultrasonic waves directed at the membrane, where the ultrasonic waves induce oscillations in at least a portion of the membrane and thereby the solvent of the solution passes through the membrane at a second rate that is greater than the first rate.Type: ApplicationFiled: November 5, 2013Publication date: September 10, 2015Applicant: University of Washington Through Its Center for CommercializationInventors: Pierre D. Mourad, Jaffer Alali, Brian Macconaghy
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Publication number: 20150142007Abstract: The present technology relates generally to surgical devices for male circumcision and associated systems and methods. In some embodiments, a circumcision device configured in accordance with the technology comprises an outer member configured to be positioned along an exterior portion of a prepuce adjacent a glans of a penis of a human patient. The outer member may include an open-ended band moveable between an unlocked position and a plurality of locked positions. The band includes circumferentially overlapping first and second ends in each of the locked positions, and defines a closed space having a different fixed diameter in each of the locked positions. The device can also include a cylindrical inner member configured to be positioned within the band of the outer member and adjacent an inner portion of the prepuce.Type: ApplicationFiled: May 17, 2013Publication date: May 21, 2015Inventors: John N. Krieger, Michael R. Bailey, James M. Hotaling, Brian Macconaghy, Francis Olson
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Publication number: 20150017678Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.Type: ApplicationFiled: April 16, 2014Publication date: January 15, 2015Applicant: University of Washington Through Its Center for CommercializationInventors: Thomas Matula, Andrew A. Brayman, Oleg A. Sapozhnikov, Brian MacConaghy
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Publication number: 20140323857Abstract: A stylet (100) includes a handle assembly (102) with an indicator display (112) and a stiff wire assembly (120) extending distally from the handle assembly (102) having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser (120), a transmit/receive chip (132), a bandpass filter (134), a differential amplifier (136), an ADC (138), and an MCU (140), operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.Type: ApplicationFiled: December 10, 2012Publication date: October 30, 2014Applicant: University of Washington Through its Center for CommercializationInventors: Pierre D. Mourad, Samuel R. Browd, Brian MacConaghy, Revathi Murthy, Nathaniel Coulson