Abstract: The present disclosure provides methods of treating an antibody-mediated disorder (e.g., an autoimmune disease) using an FcRn antagonist, e.g., a binding polypeptide (e.g., an antibody and/or an immunoadhesin), comprising a modified Fc domain. The present disclosure also provides methods of enhancing diagnostic imaging using an FcRn antagonist disclosed herein. The present disclosure further provides methods of reducing exposure of normal tissue to a radiolabeled antibody during diagnostic imaging using an FcRn antagonist disclosed herein. Methods comprising administering to a subject a therapeutically effective amount of an FcRn antagonist disclosed herein are also provided.

Abstract: The present disclosure provides binding polypeptides (e.g., antibodies and immunoadhesins) comprising a modified Fc domain. The present disclosure also provides nucleic acids encoding the binding polypeptides, recombinant expression vectors, and host cells for making such binding polypeptides. Methods of using the binding polypeptides disclosed herein to treat disease are also provided.

Abstract: A fuel nozzle and gas turbine combustor capable of operating on multiple fuels with reduced carbon build-up to the fuel nozzle and adjacent combustor components is disclosed. The fuel nozzle incorporates a reconfigured gas fuel assembly and mixing tube to eliminate known areas of recirculation. Furthermore, the liquid fuel assembly includes reconfigured spray characteristics to further reduce droplet interaction with the mixing tube.

Abstract: A wear cover for use on a gas turbine transition duct support bracket is disclosed. The wear cover, which is manufactured from a single piece of sheet metal, does not require complex manufacturing processes or tools, thereby reducing component cost. The wear cover comprises first and second leg portions substantially parallel to each other and each generally perpendicular to a third leg portion. Each of the leg portions serve to protect a surface of a support bracket finger from excessive wear associated with frictional contact with mounting blocks of a transition duct. The wear cover is designed to slip onto a support bracket finger through a first opening and is fixed to the finger by a means such as welding.

Abstract: A borophosphosilicate glass is deposited on a substrate (50) by heating the substrate (50), and contacting the substrate with a mixture of the gases tetramethylcyclotetrasiloxane, trimethylborate, trimethylphosphite, and oxygen, without the presence of a carrier gas. The first three of the gases are produced from liquid sources by controlled vaporization and flow. The gases react at the heated substrate (50) to deposit the glass upon the substrate. In a reactor (52) for depositing the glass, the tetramethylcyclotetrasiloxane and trimethylborate are introduced at a gas inlet location (79), and the trimethylphosphite and oxygen are heated and introduced at another gas inlet location (90). The tetramethylcyclotetrasiloxane and trimethylborate mixture flows toward the location where the trimethylphosphite and oxygen are introduced, and whereat the gases are mixed. This gaseous mixture flows past the heated substrate (50) to deposit the glass thereon.