Patents by Inventor Brian Marc Pepin
Brian Marc Pepin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11833356Abstract: An electrode system for neuromodulation and for recording of signals indicative of nerve activity is provided. The system can include a plurality of electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be interconnected using flexible conductors provided on the substrate. In one implementation, the electrodes can be interconnected using conductors that have spring-like configuration. Flexibility of the conductors allows the cuff to expand and contract with the nerve without causing excessive stress/strain at the nerve-cuff interface.Type: GrantFiled: February 17, 2017Date of Patent: December 5, 2023Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Bo Lu, Brian Marc Pepin
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Patent number: 11817209Abstract: Methods and systems are provided for generating specific software implementations of neuromodulation-therapy algorithms. A dataset may be received that includes operational specifications that correspond to a plurality of types of neuromodulation-therapy implant devices. A neuromodulation-therapy design interface may provide a representation of the neuromodulation-therapy implant device. A selection if a particular representation of a particular neuromodulation-therapy implant device may be received. Hardware characteristics of the particular neuromodulation-therapy implant device may be used to determine constraints of the implant device. A listing of neuromodulation-therapy parameters that is constraining according to the constraints may be presented. In response to a selection of a parameter, executable software code corresponding to a specific implementation of a neuromodulation-therapy algorithm may be generated.Type: GrantFiled: August 19, 2020Date of Patent: November 14, 2023Assignee: Rune Labs, Inc.Inventors: Brian Marc Pepin, Miroslav Tchavdarov Kotzev
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Patent number: 11779764Abstract: Methods and systems are provided for updating neuromodulation-therapy algorithms. Sensor data may be received from a subject monitoring device that includes one or more sensors. A state of the subject within a directed-cyclic state diagram may be retrieved along with a current neuromodulation-therapy algorithm that corresponds to the state. Based on the sensor data and the current neuromodulation-therapy algorithm, a new state of the subject may be determined, the new state including an update to the current neuromodulation-therapy algorithm for the subject. In response to determining the new state, a wireless transmission that includes an identification of the new state and the update neuromodulation-therapy algorithm may be initiated to the implant device associated with the subject.Type: GrantFiled: August 19, 2020Date of Patent: October 10, 2023Assignee: Rune Labs, Inc.Inventors: Brian Marc Pepin, Miroslav Tchavdarov Kotzev
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Publication number: 20220193408Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.Type: ApplicationFiled: March 9, 2022Publication date: June 23, 2022Inventors: Brian Marc PEPIN, Brian OTIS
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Patent number: 11298544Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.Type: GrantFiled: February 17, 2017Date of Patent: April 12, 2022Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Brian Marc Pepin, Brian Otis
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Patent number: 11167143Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.Type: GrantFiled: February 12, 2018Date of Patent: November 9, 2021Assignee: Galvani Bioelectronics LimitedInventors: Brian Marc Pepin, Shiv Sabesan
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Publication number: 20210205622Abstract: An electrode system for neuromodulation and for recording of signals indicative of nerve activity is provided. The system can include a plurality of electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be interconnected using flexible conductors provided on the substrate. In one implementation, the electrodes can be interconnected using conductors that have spring-like configuration. Flexibility of the conductors allows the cuff to expand and contract with the nerve without causing excessive stress/strain at the nerve-cuff interface.Type: ApplicationFiled: February 17, 2017Publication date: July 8, 2021Inventors: Bo LU, Brian Marc PEPIN
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Publication number: 20210058257Abstract: Methods and systems are provided for securing communications with a neuromodulation-therapy implant device. A first subject-specific encryption-key value may be loaded onto a neuromodulation-therapy implant device, the first subject-specific encryption-key value being configured to generate a signature that may be included in data packets transmitted by the implant device. The signature may be generated by generating a hash value of the data of the data packet and encrypting the hash value. A request may be received from a mobile device for a second subject-specific encryption-key value that is different than but corresponds to the first subject-specific encryption-key value. The second subject-specific encryption-key value may be retrieved from a data store upon authenticating the request. The second encryption-key value corresponding to the first subject-specific encryption-key value may be transmitted to the mobile device.Type: ApplicationFiled: August 19, 2020Publication date: February 25, 2021Inventors: Brian Marc Pepin, Miroslav Tchavdarov Kotzev
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Publication number: 20210057089Abstract: Methods and systems are provided for generating specific software implementations of neuromodulation-therapy algorithms. A dataset may be received that includes operational specifications that correspond to a plurality of types of neuromodulation-therapy implant devices. A neuromodulation-therapy design interface may provide a representation of the neuromodulation-therapy implant device. A selection if a particular representation of a particular neuromodulation-therapy implant device may be received. Hardware characteristics of the particular neuromodulation-therapy implant device may be used to determine constraints of the implant device. A listing of neuromodulation-therapy parameters that is constraining according to the constraints may be presented. In response to a selection of a parameter, executable software code corresponding to a specific implementation of a neuromodulation-therapy algorithm may be generated.Type: ApplicationFiled: August 19, 2020Publication date: February 25, 2021Inventors: Brian Marc Pepin, Miroslav Tchavdarov Kotzev
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Publication number: 20210052900Abstract: Methods and systems are provided for simulating neuromodulation therapy. An identification of a particular neuromodulation-therapy implant device, an identification of a particular neuromodulation-therapy algorithm, and subject records corresponding to a subject may be received. neuromodulation-therapy simulator may execute to generated predicted performance metric for the particular neuromodulation-therapy implant device. The predicted performance may correspond to predicted physiological responses of the subject when the particular neuromodulation-therapy algorithm is executed by the particular neuromodulation-therapy implant device. The predicted performance metrics may be output.Type: ApplicationFiled: August 19, 2020Publication date: February 25, 2021Inventors: Brian Marc Pepin, Miroslav Tchavdarov Kotzev
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Publication number: 20210052901Abstract: Methods and systems are provided for updating neuromodulation-therapy algorithms. Sensor data may be received from a subject monitoring device that includes one or more sensors. A state of the subject within a directed-cyclic state diagram may be retrieved along with a current neuromodulation-therapy algorithm that corresponds to the state. Based on the sensor data and the current neuromodulation-therapy algorithm, a new state of the subject may be determined, the new state including an update to the current neuromodulation-therapy algorithm for the subject. In response to determining the new state, a wireless transmission that includes an identification of the new state and the update neuromodulation-therapy algorithm may be initiated to the implant device associated with the subject.Type: ApplicationFiled: August 19, 2020Publication date: February 25, 2021Inventors: Brian Marc Pepin, Miroslav Tchavdarov Kotzev
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Patent number: 10873102Abstract: An example device includes a lithium-based battery having conductive battery contacts protruding from a surface of the battery, where a non-conductive portion of the surface of the battery separates the conductive battery contacts. The battery is a type that undergoes an expansion during charging in which the expansion of the lithium-based battery includes an outward bulging of the non-conductive portion of the battery surface. The device includes a substrate having conductive substrate contacts. The conductive battery contacts are electrically connected to the respective conductive substrate contact via a flexible electrically-conductive adhesive that physically separates the conductive battery contacts from the respective conductive substrate contacts and allows for relative movement therebetween caused by the expansion of the lithium-based battery.Type: GrantFiled: May 7, 2018Date of Patent: December 22, 2020Assignee: Verily Life Sciences LLCInventors: Brian Marc Pepin, Hojr Sedaghat Pisheh, Dat Phung, James Etzkorn
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Patent number: 10769245Abstract: A medication packet bundle includes one or more beacons. Each beacon may transmit a signal representing an event related to patient compliance with a medication regimen, such as removal of a packet of medication from a bundle or opening of a packet. The transmitted beacon signals can be monitored and processed to track patient compliance and adherence.Type: GrantFiled: April 13, 2016Date of Patent: September 8, 2020Assignee: Verily Life Sciences LLCInventors: James Etzkorn, Todd Whitehurst, Brian Marc Pepin, Robert Francis Wiser
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Publication number: 20200197699Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.Type: ApplicationFiled: February 17, 2017Publication date: June 25, 2020Inventors: Brian Marc PEPIN, Brian OTIS
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Patent number: 10595417Abstract: A method of manufacturing a flexible electronic circuit is provided. The method may include forming a positive photoresist mold on a flexible polymer substrate having a plurality of metal traces. The method may also include applying a conformal material coating over the positive photoresist mold, the flexible polymer substrate, and the metal traces. The method may further include removing an excess of the conformal material coating by running a blade over the positive photoresist mold. The method may also include removing the positive photoresist mold to reveal a cavity defined by the conformal material coating. The method may further include dispensing an anisotropic conductive paste into the cavity and inserting a chip into the cavity and bonding the chip to the metal traces.Type: GrantFiled: July 18, 2016Date of Patent: March 17, 2020Assignee: Verily Life Sciences LLCInventors: Brian Marc Pepin, Bo Lu
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Publication number: 20200016404Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.Type: ApplicationFiled: February 12, 2018Publication date: January 16, 2020Inventors: Brian Marc PEPIN, Shiv SABESAN
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Publication number: 20180254507Abstract: An example device includes a lithium-based battery having conductive battery contacts protruding from a surface of the battery, where a non-conductive potion of the surface of the battery separates the conductive battery contacts. The battery is a type that undergoes an expansion during charging in which the expansion of the lithium-based battery includes an outward bulging of the non-conductive portion of the battery surface. The device includes a substrate having conductive substrate contacts. The conductive battery contacts are electrically connected to the respective conductive substrate contact via a flexible electrically-conductive adhesive that physically separates the conductive battery contacts from the respective conductive substrate contacts and allows for relative movement therebetween caused by the expansion of the lithium-based battery.Type: ApplicationFiled: May 7, 2018Publication date: September 6, 2018Inventors: Brian Marc Pepin, Hojr Sedaghat Pisheh, Dat Phung, James Etzkorn
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Patent number: 9991550Abstract: An example device includes a lithium-based battery having conductive battery contacts protruding from a surface of the battery, where a non-conductive portion of the surface of the battery separates the conductive battery contacts. The battery is a type that undergoes an expansion during charging in which the expansion of the lithium-based battery includes an outward bulging of the non-conductive portion of the battery surface. The device includes a substrate having conductive substrate contacts. The conductive battery contacts are electrically connected to the respective conductive substrate contact via a flexible electrically-conductive adhesive that physically separates the conductive battery contacts from the respective conductive substrate contacts and allows for relative movement therebetween caused by the expansion of the lithium-based battery.Type: GrantFiled: April 21, 2015Date of Patent: June 5, 2018Assignee: Verily Life Sciences LLCInventors: Brian Marc Pepin, Hojr Sedaghat Pisheh, Dat Phung, James Etzkorn
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Patent number: 9962115Abstract: An eye-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the eye-mountable device, and the transparent polymer has a concave surface and a convex surface. The structure includes a substrate, an antenna comprising a conductive loop, and a sensor that is configured to detect an analyte. The substrate includes a loop portion and a tab portion, where the loop portion has an outer circumference defined by an outer diameter and an inner circumference defined by an inner diameter, and where the tab portion extends from the inner circumference of the loop portion towards a center of the loop portion. The conductive loop is disposed on the loop portion of the substrate between the inner circumference and outer circumference, and the sensor is disposed on the tab portion of the substrate.Type: GrantFiled: May 30, 2017Date of Patent: May 8, 2018Assignee: Verily Life Sciences LLCInventors: Brian Marc Pepin, James Etzkorn, Mandy Philippine, Stephen O'Driscoll
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Patent number: 9941830Abstract: The current application is directed to various types of linear vibrational modules, including linear-resonant vibration modules that can be incorporated in a wide variety of appliances, devices, and systems to provide vibrational forces. The vibrational forces are produced by linear oscillation of a weight or member, in turn produced by rapidly alternating the polarity of one or more driving electromagnets. Feedback control is used to maintain the vibrational frequency of linear-resonant vibration module at or near the resonant frequency for the linear-resonant vibration module. Both linear vibration modules and linear-resonant vibration modules can be designed to produce vibrational amplitude/frequency combinations throughout a large region of amplitude/frequency space.Type: GrantFiled: June 13, 2016Date of Patent: April 10, 2018Assignee: Resonant Systems, Inc.Inventors: Robin Elenga, Brian Marc Pepin, Glen Tompkins