Abstract: Embodiments herein include variants of ?-hexosaminidase that are useful for hydrolyzing GM2 ganglioside, polynucleotides encoding the same, and related methods. In various embodiments, a variant ?-hexosaminidase subunit is included wherein the variant ?-hexosaminidase subunit forms a homodimer under physiological conditions and wherein the variant ?-hexosaminidase subunit associates with GM2 activator protein to hydrolyze GM2 ganglioside. In some embodiments, an isolated or recombinant polynucleotide encoding such a variant ?-hexosaminidase subunit is included. In some embodiments, a method of treating a subject exhibiting an abnormal cellular accumulation of GM2 ganglioside is included wherein the method includes administering a composition including a protein variant of ?-hexosaminidase or a polynucleotide encoding the same. Other embodiments are included herein.

Abstract: Embodiments herein include variants of ?-hexosaminidase that are useful for hydrolyzing GM2 ganglioside, polynucleotides encoding the same, and related methods. In various embodiments, a variant ?-hexosaminidase subunit is included wherein the variant ?-hexosaminidase subunit forms a homodimer under physiological conditions and wherein the variant ?-hexosaminidase subunit associates with GM2 activator protein to hydrolyze GM2 ganglioside. In some embodiments, an isolated or recombinant polynucleotide encoding such a variant ?-hexosaminidase subunit is included. In some embodiments, a method of treating a subject exhibiting an abnormal cellular accumulation of GM2 ganglioside is included wherein the method includes administering a composition including a protein variant of ?-hexosaminidase or a polynucleotide encoding the same. Other embodiments are included herein.

Abstract: Embodiments of the present invention provide a method for tracking link mobility between two mobile nodes. Each node estimates a link mobility state of a link between itself and each of its neighbor nodes, accumulates successively the link mobility states, estimates link mobility parameters using the successively estimated link mobility states, and predicts a link availability probability using the link mobility parameters. The link mobility tracking can be applied to various routing protocols so as to implement mobility aware routing which enhance the routing performance.

Abstract: Embodiments of the present invention provide a method for tracking link mobility between two mobile nodes. Each node estimates a link mobility state of a link between itself and each of its neighbor nodes, accumulates successively the link mobility states, estimates link mobility parameters using the successively estimated link mobility states, and predicts a link availability probability using the link mobility parameters. The link mobility tracking can be applied to various routing protocols so as to implement mobility aware routing which enhance the routing performance.

Abstract: Disclosed is a cellular network handoff decision mechanism which comprising the steps of: determining a sampling interval using a carrier wavelength; determining a local averaging interval that is larger than the sampling interval; determining a handoff decision interval that is larger than the local averaging interval; selecting at least two base stations from a multitude of base stations having a pilot signal from a reference cellular network using a selection criterion; determining a received signal strength from the pilot signal strength for each of the selected base stations once during every sampling interval; calculating a local average signal strength value using each of the received signal strengths once during every local averaging interval; determining an assignment region in which the local average signal strength value lies using a hysteresis range; and calculating a handoff decision once during every handoff decision interval using a handoff calculation.

Abstract: An ad-hoc network and routing method that takes account of mobility are provided. The ad-hoc network includes at least one node, which calculates a probability that a neighbor node is present in a transmission range of the node, generates a message containing the calculated probability, and transmits the message to the neighbor node. The at least one node may also update the message with a lower probability of the calculated probability and a probability contained in the message, and transmit the updated message to the neighbor node. The node may also determine as a route a path along which a message is transmitted from the message containing the highest probability among probabilities contained in messages that are received.

Abstract: Disclosed is a cellular network handoff decision mechanism which comprising the steps of: determining a sampling interval using a carrier wavelength; determining a local averaging interval that is larger than the sampling interval; determining a handoff decision interval that is larger than the local averaging interval; selecting at least two base stations from a multitude of base stations having a pilot signal from a reference cellular network using a selection criterion; determining a received signal strength from the pilot signal strength for each of the selected base stations once during every sampling interval; calculating a local average signal strength value using each of the received signal strengths once during every local averaging interval; determining an assignment region in which the local average signal strength value lies using a hysteresis range; and calculating a handoff decision once during every handoff decision interval using a handoff calculation.

Abstract: A buffer management scheme for an ATM switch where the static and dynamic thresholds are applied appropriately at different levels to ensure efficient and fair usage of buffer memory. A novel dynamic threshold mechanism which, while ensuring fair sharing of memory, maximizes the overall memory utilization.