Abstract: An implant, artificial or semi-artificial at implantation, for repairing an articular cartilage and osteochondral defect site in a mammalian, such as a human. The implant having at least a first surface and a second surface. The first surface shaped for being press-fitted into the defect site to create an interface between the first surface and a bone-cartilage region of the defect site, and the second surface shaped for being press-fitted into the defect site to create an interface between the second surface and an articular cartilage region of the defect site. The implant being seeded, prior to implantation, with chondroprogenitor cells, including superficial zone chondroprogenitor cells.

Abstract: The present invention relates to an apparatus for, and methods of assessing cell viability in a biological sample comprising cells or tissue. In particular the present invention provides quality assurance assays for complex biomaterials, especially but not exclusively cells derived from the pancreas, liver, kidney, lung, bone marrow and stem cells, for use in biomedical procedures. The present invention provides inter alia methods of improving assessment of donor cell/tissue viability, methods of improving the success of donor cell/tissue transplant procedures, methods of assessing the functional properties of complex biological materials prior to their use in regenerative therapies and kits therefor.

Abstract: A wound dressing which comprises a carrier layer having a non-adherent to cell layer on a wound facing surface thereof. The non-adherent layer has bonded thereto a biodegradable cell anchoring layer which anchors mammalian cells. In use, the degradable layer breaks down releasing the cells into the wound site which are discouraged from reattaching to the dressing by the non-adherent layer. Thus the dressing can switch from a cell binding state to a state in which the binding of cells is discouraged. Systems, methods of treatment and methods of manufacturing the dressing are also disclosed.

Abstract: A medicament or device for tissue regeneration, for example bone and/or cartilage tissue, in which the medicament or device comprises a BMP binding protein.

Abstract: The Invention relates to a medicament and method of treating cartilage defect. The invention also relates to an implant for treating cartilage defect.