Patents by Inventor Brian Matthew Eklov

Brian Matthew Eklov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12221452
    Abstract: The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e.
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: February 11, 2025
    Assignee: Verrica Pharmaceuticals Inc.
    Inventors: Matthew Gene Davidson, Brian Matthew Eklov, Peter Wuts, Brad Melvin Loertscher, Steven R. Schow
  • Publication number: 20240109911
    Abstract: The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e.
    Type: Application
    Filed: October 30, 2023
    Publication date: April 4, 2024
    Applicant: Verrica Pharmaceuticals Inc.
    Inventors: Matthew Gene Davidson, Brian Matthew Eklov, Peter Wuts, Brad Melvin Loertscher, Steven R. Schow
  • Publication number: 20200270269
    Abstract: The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).
    Type: Application
    Filed: October 4, 2018
    Publication date: August 27, 2020
    Applicant: Verrica Pharmaceuticals, Inc.
    Inventors: Matthew Gene Davidson, Brian Matthew Eklov, Peter Wuts, Brad Melvin Loertscher, Steven R. Schow