Abstract: The disclosure provides methods for treating or limiting development age-related macular degeneration, comprising (a) a GPR143 receptor agonist, including but not limited to L-DOPA, L-DOPA analogues, or a pharmaceutically acceptable salt thereof, and (b) melatonin, a melatonin analogue, or a pharmaceutically acceptable salt thereof, and related compositions.

Abstract: A strip of encapsulated linear lighting with a partially encapsulated electrical connector is disclosed, as are processes for manufacturing such strips of encapsulated linear lighting. In these processes, connecting structure is connected to a strip of linear lighting. A portion of the connecting structure is then sheathed in a stopper. The stopper is used to dam a vessel or channel, the dammed vessel or channel is filled with resin, and the resin is caused or allowed to cure. The stopper protects the connecting structure from resin during the encapsulation process and leaves its contacts unencapsulated and exposed. The connecting structure can be connected to external structures, like a power cable or another segment of encapsulated linear lighting, after manufacture. A joint between the connecting structure and another structure can be overmolded or otherwise protected.

Abstract: A switchable bidirectional power converter can comprise an interleaved bridge configuration. A multi-phase grid connection to a half-bridge multi-phase switching bank can comprise a first switching half-bridge leg. A single-phase grid connection to a full-bridge single-phase switching bank can comprise the half-bridge multiphase switching bank interleaved with the full-bridge single-phase switching bank. The full-bridge single-phase switching bank can comprise the first switching halfbridge leg and a second switching half-bridge leg. A capacitor switch can be configured to switch at least two power factor correction capacitors between a parallel connection and a serial connection. The parallel connection can be to the single-phase switching bank, the first switching half-bridge leg, and the second switching half-bridge leg. The serial connection can be to the multi-phase switching bank and the first switching half-bridge leg. Such can be used in a bidirectional onboard charger.

Abstract: A method for making continuous encapsulated linear lighting is disclosed. In this method, a PCB is placed within a channel, and the channel is dammed by one or more stoppers. The dammed segment is filled and then caused or allowed to cure. The stoppers are then removed from their initial positions and moved along the channel. If one runs out of channel before the desired length of linear lighting is achieved, a second piece of channel is abutted to the previous segment of channel, the PCB is laid into it, and a segment is dammed, filled, and cured. The process continues iteratively until the desired length is achieved or more channel is required. The PCB may initially be cut to the full desired length and applied to the channel piecewise as needed.

Abstract: A method for making continuous encapsulated linear lighting is disclosed. In this method, a PCB is placed within a channel, and the channel is dammed by one or more stoppers. The dammed segment is filled and then caused or allowed to cure. The stoppers are then removed from their initial positions and moved along the channel. If one runs out of channel before the desired length of linear lighting is achieved, a second piece of channel is abutted to the previous segment of channel, the PCB is laid into it, and a segment is dammed, filled, and cured. The process continues iteratively until the desired length is achieved or more channel is required. The PCB may initially be cut to the full desired length and applied to the channel piecewise as needed.

Abstract: A method for making continuous encapsulated linear lighting is disclosed. In this method, a PCB is placed within a channel, and the channel is dammed by one or more stoppers. The dammed segment is filled and then caused or allowed to cure. The stoppers are then removed from their initial positions and moved along the channel. If one runs out of channel before the desired length of linear lighting is achieved, a second piece of channel is abutted to the previous segment of channel, the PCB is laid into it, and a segment is dammed, filled, and cured. The process continues iteratively until the desired length is achieved or more channel is required. The PCB may initially be cut to the full desired length and applied to the channel piecewise as needed.

Abstract: The disclosure relates to methods for connecting encapsulated linear lighting to power, including the use of through-hole mounting into flexible encapsulated linear lighting, and the creation of overmolds to protect electrical connections. The disclosure also relates to linear luminaires having channels that accommodate overmolds and allow electrical cables to exit the encapsulated linear lighting in desired, and controllable, directions.

Abstract: Provided herein are composition and methods for characterizing and treating disease. In particular, provided herein are compositions and methods for characterizing and treating disease (e.g., cancer) associated with activation of LINE-1 retroelements.

Abstract: The disclosure provides methods for treating or limiting development age-related macular degeneration, comprising (a) a GPR143 receptor agonist, including but not limited to L-DOPA, L-DOPA analogues, or a pharmaceutically acceptable salt thereof, and (b) melatonin, a melatonin analogue, or a pharmaceutically acceptable salt thereof, and related compositions.

Abstract: A proactive heating system for a vehicle, which is used to increase the temperature of an exhaust catalyst prior to ignition of an engine to reduce emissions. The proactive heating system is part of an exhaust system for a vehicle, and includes an electrically heated catalyst and an air pump, which are activated prior to engine ignition, to increase the temperature of a three-way catalyst such that the three-way catalyst is at the desired target threshold temperature, or light-off temperature, prior to engine ignition, eliminating the delay in emissions treatment after cold-start of the engine. The proactive heating system addresses the high level of untreated emissions emitted from an internal combustion engine before the catalytic emissions system reaches the light-off temperature. The proactive heating system provides heating of a catalyst to light-off temperature without combusting hydrocarbon fuel, which leads to engine out emissions.

Abstract: An expanded powertrain interface and strategy for an autonomous driving controller to control powertrain torque (or vehicle acceleration/deceleration) capability at the current operating point, in addition to capability for subsequent operating points at a future time based on predictive assessment of powertrain energy management, subsystem contraints/limits, and capability in the future. The powertrain interface and strategy applies to a vehicle with electrified powertrain control (hybrid electric vehicle (HEV) or pure battery electric vehicle (BEV)) with an autonomous driving (AD) capability (either full or semi-automated driving). This powertrain interface and strategy may also be used with non-electrified powertrain (conventional) systems based on available combustion engine torque at the target vehicle speed and gear.

Abstract: A proactive heating system for a vehicle, which is used to increase the temperature of an exhaust catalyst prior to ignition of an engine to reduce emissions. The proactive heating system is part of an exhaust system for a vehicle, and includes an electrically heated catalyst and an air pump, which are activated prior to engine ignition, to increase the temperature of a three-way catalyst such that the three-way catalyst is at the desired target threshold temperature, or light-off temperature, prior to engine ignition, eliminating the delay in emissions treatment after cold-start of the engine. The proactive heating system addresses the high level of untreated emissions emitted from an internal combustion engine before the catalytic emissions system reaches the light-off temperature. The proactive heating system provides heating of a catalyst to light-off temperature without combusting hydrocarbon fuel, which leads to engine out emissions.

Abstract: An expanded powertrain interface and strategy for an autonomous driving controller to control powertrain torque (or vehicle acceleration/deceleration) capability at the current operating point, in addition to capability for subsequent operating points at a future time based on predictive assessment of powertrain energy management, subsystem contraints/limits, and capability in the future. The powertrain interface and strategy applies to a vehicle with electrified powertrain control (hybrid electric vehicle (HEV) or pure battery electric vehicle (BEV)) with an autonomous driving (AD) capability (either full or semi-automated driving). This powertrain interface and strategy may also be used with non-electrified powertrain (conventional) systems based on available combustion engine torque at the target vehicle speed and gear.

Abstract: The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.

Abstract: The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.

Abstract: The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.

Abstract: The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.

Abstract: A process control system is configured via manipulation of objects that model system components, e.g., sensors, blocks, control processors, historians, workstations, etc. Individual objects include parameters that characterize the underlying components and/or the behavior of the objects themselves. These parameters are derived from the “parents,” from which the objects are created. Derived characteristics need not be defined explicitly but, rather, are defined implicitly or by reference. These derived characteristics may be overridden for an individual object and, thereby, its progeny. Although objects have class-like characteristics (i.e., insofar as they are definitional in nature), they can be created at configuration time, without the need for recompilation.

Abstract: Connection objects or other such data structures facilitate establishing and configuring connections between objects that model components in a process control system. A first set of data structures (e.g. the object connection type structures) identify valid types for component-to-component pairings and the respective roles of each component in the pairing (e.g., parent or child, source or sink). A second set of data structures (e.g., the parameter connection type structures) supply similar information for parameter-to-parameter connections. Together, these data structures can be used, for example, to validate component-to-component connections suggested by the user and to automatically configure parameter-to-parameter connections. Actual connections, both at the component or parameter level, are reflected using parameter overrides within the parameterized object model—with which the connection objects are constructed.