Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: Systems and methods for distribution, storage, transport, administration and/or disposal of one or more therapeutic or diagnostic agents are disclosed. A storage device configured to connect to a delivery system for delivering the therapeutic or diagnostic agent has a housing with a chamber, a vessel having an access port positioned within the chamber. The door is movable relative to the housing between a closed position and an open position. In the closed position, the door covers an opening in the housing to enclose the chamber, and, in the open position, the door reveals the opening for accessing the access port of the vessel. The door is moveable between the closed position and the open position in response to actuation by an access mechanism of the delivery system.

Abstract: Computer implemented systems and methods of processing clinical documentation for a multi-axial coding scheme include inputting clinical documentation from memory operatively coupled with a computer system, and executing a natural language processor configured to process narrative text in the clinical documentation. The processor segments the narrative text based on boundaries defined in the clinical documentation, sequences words in the narrative text based on the segmentation, and maps the sequenced words to semantic objects in an ontology database. The ontology defines classes of semantic objects and relationships between them, corresponding to the multi-axial coding scheme. The semantic objects are converted into characters and output into slots in a medical code, with the characters positioned in the slots based on the multi-axial coding scheme.

Abstract: A service implemented at a first isolated virtual network of a provider network is added to a database of privately-accessible services. Configuration changes that enable network packets to flow between the first isolated virtual network and a second isolated virtual network without utilizing a network address accessible from the public Internet are implemented. Service requests originating at the second isolated virtual network are transmitted to the first isolated virtual network via private pathways of the provider network. Metrics corresponding to service requests directed from the second isolated network to the service are collected and provided to the respective owners of one or both isolated virtual networks.

Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

Abstract: A rental self-service (“RSS”) computer system, including a processor and a memory, is provided. The processor is programmed to: (i) verify that a policyholder is eligible to receive a replacement rental; (ii) transmit a customized link to the eligible policyholder; (iii) receive an access request for access of a rental self-service portal, (iv) retrieve policyholder data using information extracted from the customized link; (v) pre-populate a portion of a searchable interface of the rental self-service portal using the retrieved policyholder data; (vi) cause rental vehicle data to be displayed to enable the policyholder to view available rental options and select a vehicle class; (vii) calculate a policyholder cost for renting a selected vehicle class; and (viii) cause to be displayed on the user device (a) the calculated policyholder cost and (b) an option to confirm the rental reservation.

Abstract: An analog tamper-detection apparatus (ATAMP) for onboard analysis of a target device includes a plurality of antennas, each antenna of the plurality of antennas disposed within the target device and being electrically isolated from components of the target device. The ATAMP device further includes radio frequency (RF) front-end (RFFE) transmitter circuitry coupled to the plurality of antennas, the RFFE transmitter circuitry configured to illuminate the target device with a plurality of electromagnetic signals emitted via the plurality of antennas, to generate a plurality of mixed RF signals. The ATAMP device further includes RFFE receiver circuitry configured to receive emissions from the target device based on the mixed RF signals, and processing circuitry configured to perform subsequent analysis and evaluation of the target device based on the received emissions. The processing circuitry further generates a notification of the subsequent analysis and evaluation.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server. The approaches include intercepting requests to the SaaS server from a user group and monitoring both a rate of API calls for the requests and a rate of API events generated by forwarding the API calls to the SaaS server, intercepting the SaaS server's responses, where some of the responses indicate a throughput penalty imposed by the server, identifying one or more power users from the user group based on the rate of generated notifications, and throttling the rate of the API calls for the requests submitted by the identified power users of the user group to the SaaS server in accordance with an API call throttle limit, thus reducing triggering of the throughput penalty.

Abstract: An ink composition includes a polymeric binder having an addition copolymer and a ketone aldehyde resin. The addition copolymer is chosen from acrylic resins, vinyl resins including copolymers of vinyl chloride and vinyl acetate, and mixtures and combinations thereof. The ink composition further includes a liquid carrier with at least one organic solvent.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server is disclosed. The approaches include actions of intercepting requests to the SaaS server from a user group and monitoring both a rate of API calls for the requests and a rate of API events generated by forwarding the API calls to the SaaS server, intercepting the SaaS server's responses, where some of the responses indicate a throughput penalty imposed by the server, inferring load conditions of the SaaS server by analyzing the varying rate of API events against the responses with imposition of throughput penalty and setting an API call throttle limit dynamically adaptive to the inferred load conditions, then throttling the rate of the API calls for the group's requests according to the throttle limit.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server is disclosed. The approaches include actions of intercepting requests to the SaaS server from a user group and monitoring both a rate of API calls for the requests and a rate of API events generated by forwarding the API calls to the SaaS server, intercepting the SaaS server's responses, where some of the responses indicate a throughput penalty imposed by the server, inferring load conditions of the SaaS server by analyzing the varying rate of API events against the responses with imposition of throughput penalty and setting an API call throttle limit dynamically adaptive to the inferred load conditions, then throttling the rate of the API calls for the group's requests according to the throttle limit.

Abstract: A system for adjusting the compliance of a wheel is provided. In one embodiment, wheel segments are adjusted, causing the stiffness of the wheel to change. Such adjustments can be made while the wheel is rotating, allowing the wheel compliance to be changed while a vehicle is in motion.

Abstract: An analog tamper-detection apparatus (ATAMP) for onboard analysis of a target device includes a plurality of antennas, each antenna of the plurality of antennas disposed within the target device and being electrically isolated from components of the target device. The ATAMP device further includes radio frequency (RF) front-end (RFFE) transmitter circuitry coupled to the plurality of antennas, the RFFE transmitter circuitry configured to illuminate the target device with a plurality of electromagnetic signals emitted via the plurality of antennas, to generate a plurality of mixed RF signals. The ATAMP device further includes RFFE receiver circuitry configured to receive emissions from the target device based on the mixed RF signals, and processing circuitry configured to perform subsequent analysis and evaluation of the target device based on the received emissions. The processing circuitry further generates a notification of the subsequent analysis and evaluation.

Abstract: A system for adjusting the compliance of a wheel is provided. In one embodiment, wheel segments are adjusted, causing the stiffness of the wheel to change. Such adjustments can be made while the wheel is rotating, allowing the wheel compliance to be changed while a vehicle is in motion.

Abstract: An RF clocked device can include a signal processor operable to receive an RF signal having an RF signal frequency and output a clock signal having a clock frequency based on the RF signal frequency. The RF clocked device can also include a clock operable to receive, and operate, using the clock signal. The clock can output at least one of a time and a date. In addition, a clock system can include an RF clocked device. The RF clocked device can include a signal processor operable to receive an RF signal having an RF signal frequency and output a clock signal having a clock frequency based on the RF signal frequency. The RF clocked device can also include a clock operable to receive, and operate, using the clock signal. The clock can output at least one of a time and a date. The clock system can also include a client device operable to receive timing information from the RF clocked device.

Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

Abstract: A rental self-service (“RSS”) computer system, including a processor and a memory, is provided. The processor is programmed to: (i) verify that a policyholder is eligible to receive a replacement rental; (ii) transmit a customized link to the eligible policyholder; (iii) receive an access request for access of a rental self-service portal, (iv) retrieve policyholder data using information extracted from the customized link; (v) pre-populate a portion of a searchable interface of the rental self-service portal using the retrieved policyholder data; (vi) cause rental vehicle data to be displayed to enable the policyholder to view available rental options and select a vehicle class; (vii) calculate a policyholder cost for renting a selected vehicle class; and (viii) cause to be displayed on the user device (a) the calculated policyholder cost and (b) an option to confirm the rental reservation.

Abstract: An analog tamper-detection apparatus (ATAMP) for onboard analysis of a target device includes a plurality of antennas, each antenna of the plurality of antennas disposed within the target device and being electrically isolated from components of the target device. The ATAMP device further includes radio frequency (RF) front-end (RFFE) transmitter circuitry coupled to the plurality of antennas, the RFFE transmitter circuitry configured to illuminate the target device with a plurality of electromagnetic signals emitted via the plurality of antennas, to generate a plurality of mixed RF signals. The ATAMP device further includes RFFE receiver circuitry configured to receive emissions from the target device based on the mixed RF signals, and processing circuitry configured to perform subsequent analysis and evaluation of the target device based on the received emissions. The processing circuitry further generates a notification of the subsequent analysis and evaluation.

Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.