Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.

Abstract: An embodiment includes a method of real-time, endpoint-specific SLA compliance evaluation in a managed network. The method includes receiving SLA definition input that indicates an SLA definition of the managed network. Responsive to detection of a trigger event, the method includes initiating a scan of endpoints including retrieval of endpoint-level state data. The method includes identifying a portion of the retrieved state data relevant to the SLA definition. The method includes aggregating the portions of the retrieved state data. The method includes determining whether the managed network is SLA compliant at an endpoint-level of granularity based on the aggregated portions. Responsive to the managed network being noncompliant, the method includes identifying a subset of endpoints failing to meet the SLA definition and implementing a product modification process to address a metric of the SLA definition and change a product to bring the first endpoint into compliance.

Abstract: A method and system for order management that allows access to additional pools of liquidity is described. Other embodiments are also described.

Abstract: The systems and methods described can include approaches to calibrate head-mounted displays for improved viewing experiences. Some methods include receiving data of a first target image associated with an undeformed state of a first eyepiece of a head-mounted display device; receiving data of a first captured image associated with deformed state of the first eyepiece of the head-mounted display device; determining a first transformation that maps the first captured image to the image; and applying the first transformation to a subsequent image for viewing on the first eyepiece of the head-mounted display device.

Abstract: Devices and methods for mixing and preparing therapeutic pellets are described. In one aspect, the present disclosure may include a medical device for mixing and preparing pharmaceuticals. The medical device may include a body sized and shaped to be supported by a human hand. The body may be elastically flexible between a relaxed shape and a flexed shape. In the relaxed shape, the body may form a basin and may be shaped and sized to receive a vessel for mixing or forming the therapeutic pellets. In the flexed shape, the bowl may be configured for controlled pouring of the therapeutic pellets.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: Systems and methods are disclosed for an enclosure providing a sealed environment. The enclosure employs movable paneling that seals an area for a laser welding cell, while allowing access for an operator to load a workpiece in and unload the workpiece from a welding cell. Barriers are arranged on the enclosure, such that in a closed configuration activation of a pneumatic tube forces the barriers to extend toward a rotated paneling, such that the edges of the enclosure contact or overlap with the edges of the paneling to result in a light-tight seal. Presence of the fluid increases the pressure in the tube such that an external boundary of the tube expands, forcing the barrier toward the edges of the paneling, thereby closing the gap and providing a light-tight enclosure.

Abstract: Policy-based network transmission routing is provided by accessing routing metadata in a wrapper of the transmission packet, the routing metadata representing a feature of the source or the destination, comparing the routing metadata to routing policy data associated with each of multiple routing policies defined within a routing policy structure, identifying, based on the comparing, one or more routing policies applicable to the transmission packet, identifying, based on the routing policy data, a highest priority routing policy from the one or more routing policies, the highest priority routing policy defining a route constraint usable to limit a selection of available routes to the destination, and selecting the route from the available routes based on the route constraint.

Abstract: A trading platform and trading method that may allow access to additional pools of liquidity is described. Other embodiments are also described.

Abstract: Provided herein is a system for producing a product. The system generally comprises a large-area micro-stereolithography system, an optical imaging system, and a controller in communication with the large-area micro-stereolithography system and the optical imaging system. The large-area micro-stereolithography system is capable of generating the product by optically polymerizing successive layers of a curable resin at a build plane. The controller is capable of analyzing a focus level of the reference target based on the captured image; and based on the analyzing, adjusting a focus property of the projected image beam of the stereolithography system.

Abstract: A method and system for reducing triggering of throughput penalties imposed on a group of users by a software-as-a-service (SaaS) server due to Application Programming Interface (API) calls exceeding limits of the SaaS server. The approaches include intercepting requests to the SaaS server from a user group and monitoring a rate of API calls the API calls forwarded to the SaaS server, identifying one or more power users based on a notification threshold value for the user group, and managing the rate of the API calls for the requests submitted by the identified power users of the user group in accordance with an API call throttle limit, thus remediating triggering of the throughput penalty.

Abstract: Methods for making an aqueous polyaluminum chloride (PAC) are disclosed that include adding an amount of a chloride-containing aluminum compound simultaneously with an amount of a base to a reaction vessel, mixing the two solutions in the reaction vessel, to produce a mixture, until a pH between 4.5 and 10 of the mixture is attained, maintaining the pH of the mixture between 4.5 and 10 during the mixing to produce an aluminum hydroxide precipitate dispersed in a liquid, allowing the aluminum hydroxide precipitate in the mixture to settle and creating a supernatant liquid, removing an amount of the supernatant liquid from the mixture to form a slurry, and adding a low- to mid-basicity polyaluminum chloride solution, an aluminum chloride solution, and/or a hydrochloric acid solution to the slurry to dissolve the aluminum hydroxide precipitate to form the aqueous polyaluminum chloride.

Abstract: Devices and methods for mixing and preparing therapeutic pellets are described. In one aspect, the present disclosure may include a medical device for mixing and preparing pharmaceuticals. The medical device may include a body sized and shaped to be supported by a human hand. The body may be elastically flexible between a relaxed shape and a flexed shape. In the relaxed shape, the body may form a basin and may be shaped and sized to receive a vessel for mixing or forming the therapeutic pellets. In the flexed shape, the bowl may be configured for controlled pouring of the therapeutic pellets.

Abstract: Policy-based network transmission routing is provided by accessing routing metadata in a wrapper of the transmission packet, the routing metadata representing a feature of the source or the destination, comparing the routing metadata to routing policy data associated with each of multiple routing policies defined within a routing policy structure, identifying, based on the comparing, one or more routing policies applicable to the transmission packet, identifying, based on the routing policy data, a highest priority routing policy from the one or more routing policies, the highest priority routing policy defining a route constraint usable to limit a selection of available routes to the destination, and selecting the route from the available routes based on the route constraint.

Abstract: A fuel cell system includes a dry end unit, a wet end unit comprising a terminal-compression plate, an insulator plate, and a base plate, and a plurality of fuel cells disposed between the dry end unit and the wet end unit. Each of the plurality of fuel cells includes a perimeter area that surrounds the plurality of fuel cells. The terminal-compression plate functions as a compression plate and a terminal plate, and where the base plate is used to uniformly compress the plurality of fuel cells through the insulator plate and the terminal-compression plate.

Abstract: A molecular manufacturing process includes contacting a platform molecule with (i) a biocatalyst and (ii) a chemical catalyst under conditions suitable to produce a value-added chemical.

Abstract: A power tool includes a housing, a nosepiece, and an end effector rotatably coupled to the housing. A substantially annular holder body is axially and non-rotatably coupled to the nosepiece. A circuit board is received in an internal substantially annular groove in a rear face of the front wall of the holder body between the holder body and the nosepiece. A light unit is coupled to the circuit board and configured to illuminate the workpiece. A wire assembly electrically couples the light unit to a source of electrical power.

Abstract: A system, method and apparatus for applying container carriers to unitize a plurality of containers. A supply of container carriers are provided in a stack and grouped into sticks of multiple adjacent container carriers. A magazine accommodates the stack of container carrier sticks and a carrier feed draws a single container carrier stick from the magazine. A transport section comprising two or more container carrier sticks aligned in a queue provides single container carrier sticks to an applicating drum configured to apply to a corresponding group of containers.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: A system for facilitating a response to an event notifying signal is disclosed herein. The system comprises: a network monitoring module configured for monitoring signals received over a data network for a presence of one or more event notifying signals indicative of a relevant incident within a geographic area; and an assessment module configured for determining if the relevant incident could impact any persons or property of an enterprise or organization within the geographic area and identifying a first group of people of the enterprise or organization who could be impacted by the relevant incident. The system further comprising the resource response module configured for communicating a response to a computing device associated with each person of the first group of people, where the response provides indication of the relevant incident.