Patents by Inventor Brian Morgan Watson

Brian Morgan Watson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GIP/GLP1 CO-AGONIST COMPOUNDS
    Publication number: 20230265151
    Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. These compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). These compounds may be useful in the treatment of obesity.
    Type: Application
    Filed: January 21, 2021
    Publication date: August 24, 2023
    Inventors: Jorge ALSINA-FERNANDEZ, Robert Andrew BROWN, Robert Chadwick CUMMINS, Mohamed Elsayed Hamed ELSAYED, Andrea Renee GEISER, Xianyin LAI, Hongchang QU, Brian Morgan WATSON
  • AHR AGONISTS
    Publication number: 20230159493
    Abstract: The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.
    Type: Application
    Filed: September 13, 2022
    Publication date: May 25, 2023
    Inventors: Lacie Marie CHAUVIGNE-HINES, Christian Alexander CLARKE, Douglas Linn GERNERT, Steven James GREEN, Brian Morgan WATSON
  • IL-17A INHIBITORS
    Publication number: 20220073526
    Abstract: The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.
    Type: Application
    Filed: January 3, 2020
    Publication date: March 10, 2022
    Inventors: David Andrew Coates, Kwame Frimpong, William Glen Holloway, Brian Spencer Jones, Adam Marc Levinson, Charles Willis Lugar, III, Michael Enrico Richett, Brian Morgan Watson, Michael Edward Woodman
  • 5'-SUBSTITUTED NUCLEOSIDE COMPOUNDS
    Publication number: 20160326208
    Abstract: The present invention relates to novel 5?-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancreatic cancer, cholangiocarcinoma, bladder cancer, breast cancer, non-small cell lung cancer, leukemias including acute myeloid leukemia, and lymphomas.
    Type: Application
    Filed: April 27, 2016
    Publication date: November 10, 2016
    Inventors: Guillermo S CORTEZ, Karl Robert DAHNKE, Michael John GROGAN, Antonio Rodriguez HERGUETA, James Andrew JAMISON, Brian Morgan WATSON, Timothy Andrew WOODS, Zahid Quyoom BONDAY
  • BACE inhibitors
    Patent number: 9169271
    Abstract: The present invention provides a compound of Formula III: wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 27, 2015
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Erik James Hembre, Dustin James Mergott, Yuan Shi, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • BACE INHIBITORS
    Publication number: 20150210716
    Abstract: The present invention provides a compound of Formula III: wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 2, 2015
    Publication date: July 30, 2015
    Inventors: Steven James GREEN, Erik James HEMBRE, Dustin James MERGOTT, Yuan SHI, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20150157641
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 19, 2015
    Publication date: June 11, 2015
    Inventors: Steven James GREEN, Dustin James MERGOTT, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • BACE inhibitors
    Patent number: 9029367
    Abstract: The present invention provides a compound of Formula III: Formula III wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof, which is useful for treating Alzheimer's disease.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: May 12, 2015
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Erik James Hembre, Dustin James Mergott, Yuan Shi, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • Tetrahydropyrrolothiazine compounds
    Patent number: 8987254
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: March 24, 2015
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Dustin James Mergott, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • BACE INHIBITORS
    Publication number: 20140371212
    Abstract: The present invention provides a compound of Formula III: wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 11, 2014
    Publication date: December 18, 2014
    Inventors: Steven James GREEN, Erik James HEMBRE, Dustin James MERGOTT, Yuan SHI, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20140350245
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: Steven James GREEN, Dustin James MERGOTT, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • Tetrahydropyrrolothiazine compounds
    Patent number: 8889856
    Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: November 18, 2014
    Assignee: Eli Lilly and Company
    Inventors: James Peter Beck, Steven James Green, Jose Eduardo Lopez, Brian Michael Mathes, Dustin James Mergott, Warren Jaye Porter, Zoran Rankovic, Yuan Shi, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • Tetrahydropyrrolothiazine compounds
    Patent number: 8841293
    Abstract: The present invention provides a compound of Formula I: Formula I wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: September 23, 2014
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Dustin James Mergott, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20140275044
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 4, 2014
    Publication date: September 18, 2014
    Applicant: Eli Lilly and Company
    Inventors: Steven James GREEN, Dustin James MERGOTT, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20140256933
    Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Applicant: Eli Lilly and Company
    Inventors: James Peter BECK, Steven James GREEN, Jose Eduardo LOPEZ, Brian Michael MATHES, Dustin James MERGOTT, Warren Jaye PORTER, Zoran RANKOVIC, Yuan SHI, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • Tetrahydropyrrolothiazine compounds
    Patent number: 8772282
    Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: July 8, 2014
    Assignee: Eli Lilly and Company
    Inventors: James Peter Beck, Steven James Green, Jose Eduardo Lopez, Brian Michael Mathes, Dustin James Mergott, Warren Jaye Porter, Zoran Rankovic, Yuan Shi, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20140094454
    Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 4, 2013
    Publication date: April 3, 2014
    Applicant: Eli Lilly and Company
    Inventors: James Peter BECK, Steven James GREEN, Jose Eduardo LOPEZ, Brian Michael MATHES, Dustin James MERGOTT, Warren Jaye PORTER, Zoran RANKOVIC, Yuan SHI, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20130261111
    Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 3, 2013
    Applicant: Eli Lilly and Company
    Inventors: James Peter BECK, Steven James GREEN, Jose Eduardo LOPEZ, Brian Michael MATHES, Dustin James MERGOTT, Warren Jaye PORTER, Zoran RANKOVIC, Yuan SHI, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR
  • Pyridine derivatives as dipeptedyl peptidase inhibitors
    Patent number: 8133907
    Abstract: The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (1); X is selected from CH, CF and N; R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroalkyl, and —OR12; R9 is selected from H —NR13C(O)R14 and —C(O)NR10R11; R12 is selected from H, C1-C6 alkyl and C3-C6 cycloalkyl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: March 13, 2012
    Assignee: Eli Lilly and Company
    Inventors: Larry Chris Blaszczak, Brian Michael Mathes, Shon Roland Pulley, Michael Alan Robertson, Scott Martin Sheehan, Qing Shi, Brian Morgan Watson, Michael Robert Wiley
  • Phenyl compounds and their use in the treatment of Type II diabetes
    Patent number: 8076514
    Abstract: The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (xx); X is selected from CH, CF and N, R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroalkyl, and —OR12, R9 is selected from H and —C(O)NR1OR1 1, R12 is selected from H, C1-C6 alkyl and C3-C6 cycloalkyl for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: December 13, 2011
    Assignee: Eli Lilly and Company
    Inventors: Larry Chris Blaszczak, Shon Roland Pulley, Michael Alan Robertson, Scott Martin Sheehan, Qing Shi, Brian Morgan Watson, Michael Robert Wiley