Patents by Inventor Brian Mouridsen
Brian Mouridsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230372687Abstract: A capsule device (100) suitable for insertion or ingestion into a lumen, such as a gastrointestinal lumen, of a subject.Type: ApplicationFiled: October 8, 2021Publication date: November 23, 2023Inventors: Aghiad Ghazal, Drago Sticker, Jacob Pyung Hwa Jepsen, Cody Edward Cleveland, Jorrit Jeroen Water, Brian Mouridsen
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Publication number: 20230338718Abstract: The swallowable capsule device (10) comprises a capsule housing (12), a drug outlet (14) arranged relative to the capsule housing (12), a drug reservoir (16) configured to accommodate a drug substance (23) in use, and a needleless jet injector assembly. The needleless jet injector assembly includes a jet injector (22) and an actuator. The jet injector (22) has a plurality of jet nozzles (24) and the actuator is configured to actuate under predetermined conditions to expel the drug substance (23) in use from the drug reservoir out through the drug outlet (14) via the jet nozzles (24) to form a jet stream. Each jet nozzle (24) is configured to expel a separate collimated jet stream (28) having a peak jetting power of 1 W or below, and the plurality of jet nozzles (24) are arranged in a cluster so that the separate collimated jet streams (24) in combination form a contiguous jet stream (20) that is configured to be expelled towards the lumen wall.Type: ApplicationFiled: September 30, 2021Publication date: October 26, 2023Inventors: Jorrit Jeroen Water, Brian Mouridsen, Drago Sticker, Aghiad Ghazal, Jacob Pyung Hwa Jepsen, Peter Herskind, Cody Edward Cleveland
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Publication number: 20230338719Abstract: 1. A capsule device (100) suitable for swallowing into a lumen of a gastrointestinal tract of a patient and for intestinal delivery of a therapeutic substance from the capsule device, wherein the capsule device (100) comprises: a) a housing portion (110, 115, 120), b) an activation element (130) movable relative to the housing portion from an expanded pre-delivery configuration into a non-expanded delivery configuration, c) a therapeutic substance comprised in a reservoir (A), and d) a delivery assembly comprising an actuator (140) comprising a potential energy source and a delivery outlet (190). The activation element (130) is movable by intestinal wall peristaltic contraction from the ex-panded pre-delivery configuration into the non-expanded delivery configuration to cause the actuator (140) to deliver the therapeutic substance through the delivery outlet (190).Type: ApplicationFiled: November 1, 2021Publication date: October 26, 2023Inventors: Adam Jun Bohr, Mikkel Oliver Bruun-Jespersen, Jorrit Jeroen Water, Brian Mouridsen, Bozhidar Nikolaev Kozhuharov
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Publication number: 20230330402Abstract: A capsule device (10) suitable for swallowing into a lumen of an intestinal tract of a patient comprises a housing section (12), a delivery outlet (20) for jet injection by a delivery assembly (22), an expansion assembly (26) and an expansion control mechanism (30). The expansion section (28) is arranged laterally opposite to and physically separated from the delivery outlet (20). An expansion section (28) of the expansion assembly (26) is laterally expandable from a non-expanded configuration to an expanded configuration for positioning the delivery outlet (20) against the lumen wall (14). The expansion control mechanism (30) is configured to activate the expansion assembly (26) under a predetermined condition to permit change of the expansion section (28) from the non-expanded configuration to the expanded configuration.Type: ApplicationFiled: September 29, 2021Publication date: October 19, 2023Inventors: Jorrit Jeroen Water, Brian Mouridsen, Drago Sticker, Aghiad Ghazal, Adam Jun Bohr, Jacob Pyung Hwa Jepsen, Peter Herskind, Cody Edward Cleveland, Jens Lolle Laursen
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Publication number: 20230321415Abstract: A capsule device (100) suitable for insertion into a lumen, such as a gastrointestinal lumen, of a subject. The capsule device (100) comprises: a capsule housing (110, 120), a drug chamber (B) configured to accommodate a drug substance, the drug chamber leading to a drug outlet (190),—an actuation chamber (A),—a movable separator (160) arranged between the actuation chamber and the drug chamber, wherein movement of the movable separator expels drug substance from the drug chamber (B) through the drug outlet (190), and—a gas generator (140, 150) configured actuatable to generate pressurized gas in the actuation chamber (A) for exerting mechanical load on the moveable separator (160) to expel the drug substance.Type: ApplicationFiled: September 29, 2021Publication date: October 12, 2023Inventors: Brian Mouridsen, Drago Sticker, Aghiad Ghazal, Andre Larsen, Jacob Pyung Hwa Jepsen
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Patent number: 11771829Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent.Type: GrantFiled: January 31, 2020Date of Patent: October 3, 2023Assignees: Massachusetts Institute of Technology, Novo Nordisk A/S, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, Morten Revsgaard Frederiksen, Mikkel Oliver Jespersen, Brian Mouridsen, Jesper Windum, Mette Poulsen, Brian Jensen, Jorrit Jeroen Water, Mikkel Wennemoes Hvitfeld Ley, Xiaoya Lu, Andreas Vegge
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Publication number: 20230277823Abstract: A capsule (100) suitable for insertion into a gastrointestinal lumen. The capsule (100) comprises: a capsule housing (110, 120), a reservoir (A) accommodating a drug substance, a drug outlet (190), an actuation chamber (118), a movable separator (160) between the actuation chamber (118) and the reservoir (A), and a drive system comprising a gas expansion unit (150) and a trigger (145, 140, 170). The gas expansion unit (150) comprises a gas gate (151) and the trigger (145, 140, 170) comprises a trigger member (170) and a swellable portion (140) comprising sponge material, wherein wetting of the sponge material causes swelling of the sponge material thereby causing relative movement between the gas expansion unit (150) and the trigger member (170) to open the gas gate (151). Pressurized gas flows from them to the actuation chamber (118) thereby exerting load on the separator (160) for expelling the drug substance.Type: ApplicationFiled: August 5, 2021Publication date: September 7, 2023Inventors: Brian Mouridsen, Jacob Pyung Hwa Jepsen, Nikolaj Eusebius Jakobsen, Drago Sticker, Aghiad Ghazal
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Publication number: 20230263956Abstract: A drug delivery device for administration to a subject may include a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device may also include a trigger operatively associated with the potential energy source. The trigger may be configured to actuate at a predetermined location within the subject to deploy a jet of the active pharmaceutical ingredient into a tissue of an adjacent portion of the gastrointestinal tract. In some instances, the jet may be deployed into tissue of the stomach and/or small intestine of the subject. Further, in some embodiments, the operating parameters of the jet may be selected such that the jet penetrates the tissue of the gastrointestinal tract to form a depot of the active pharmaceutical ingredient disposed within the tissue.Type: ApplicationFiled: August 9, 2021Publication date: August 24, 2023Applicants: Massachusetts Institute of Technology, Novo Nordisk A/SInventors: Graham Arrick, Declan Gwynne, Jacob Wainer, Carlo Giovanni Traverso, Drago Sticker, Cody Cleveland, Aghiad Ghazal, Jorrit Jeroen Water, Brian Mouridsen, Mette Poulsen, Dan Nørtoft Sørensen, Jacob Pyung Hwa Jepsen
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Patent number: 11596747Abstract: An add-on device adapted to be releasably mounted on a drug delivery device, the add-on device comprising an outer assembly with an add-on dose setting member adapted to be coupled to the outer housing of a pen housing, as well as an inner assembly engaging the pen dose setting member and being in rotational engagement with the add-on dose setting member during dose setting. The invention addresses the issue of preventing transfer of movement from the add-on dose setting member to the inner assembly during dose expelling, which in accordance with the invention is realized by rotationally de-coupling the inner and outer assembly during dose expelling.Type: GrantFiled: September 21, 2018Date of Patent: March 7, 2023Assignee: Novo Nordisk A/SInventors: Bennie Peder Smiszek Pedersen, Brian Mouridsen, Jesper Hoeholt, Steven Linnebjerg, Lars Morten Bom
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Publication number: 20220105330Abstract: A medical delivery device suitable for insertion into a lumen of a patient, the medical device (100, 200) comprising a capsule (110, 120, 210, 220) sized to be inserted into the lumen, the capsule comprising a base member, and an actuation mechanism comprising an actuation member (150, 250, 350) configured for movement relative to the base member along an axis, and an energy source (140, 240, 340) associated with the actuation member for powering the actuation member to move relative to the base member along the axis.Type: ApplicationFiled: January 31, 2020Publication date: April 7, 2022Inventors: Brian Jensen, Morten Revsgaard Frederiksen, Brian Mouridsen, Jacob Pyung Hwa Jepsen
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Publication number: 20220088316Abstract: An add-on device adapted to be releasably mounted on a drug delivery device, the add-on device comprising an outer assembly with an add-on dose setting member adapted to be coupled to the outer housing of a pen housing, as well as an inner sensor assembly engaging the pen dose setting member and being in rotational engagement with the add-on dose setting member during dose setting. The invention addresses the issue of providing a stable inner platform for the sensor means, which in accordance with the invention is realized by actuating a clutch between the pen housing and the pen dose setting member during dose sensing, this preventing to a high degree that the inner sensor assembly rotates relative to the drug delivery housing during actuation of the drug expelling means.Type: ApplicationFiled: September 21, 2018Publication date: March 24, 2022Inventors: Lars Morten Bom, Bennie Peder Smiszek Pedersen, Brian Mouridsen, Jesper Hoeholt
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Publication number: 20220039686Abstract: A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.Type: ApplicationFiled: August 9, 2021Publication date: February 10, 2022Applicants: Massachusetts Institute of Technology, NOVO NORDISK A/S, The Brigham and Women's Hospital, Inc.Inventors: Graham Arrick, Torben Sebastian Last, Declan Gwynne, Jacob Wainer, Carlo Giovanni Traverso, Drago Sticker, Cody Cleveland, Aghiad Ghazal, Adam Bohr, Jorrit Jeroen Water, Brian Mouridsen, Jacob Pyung Hwa Jepsen, Bozhidar Nikolaev Kozhuharov, Kim Frandsen, Robert Langer, Yi Lu, Niclas Roxhed, Siheng You
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Publication number: 20220001110Abstract: A drug delivery assembly comprising a magnetic indicator and a sensor system is provided. The indicator is arranged to rotate and move axially relative to a housing component and corresponding to a reference axis, the amount of rotation being indicative of the size of an expelled dose amount. The sensor system comprises a sensor component adapted to measure a property of the indicator indicative of a rotational position and/or a rotational movement of the indicator. The sensor component forms part of release assembly adapted to be moved into engagement with a release member to release a set dose, and subsequently to move axially together with indicator.Type: ApplicationFiled: December 3, 2019Publication date: January 6, 2022Inventors: Lars Morten Bom, Brian Mouridsen, Jesper Hoeholt, Bennie Peder Smiszek Pedersen
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Publication number: 20200246545Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent.Type: ApplicationFiled: January 31, 2020Publication date: August 6, 2020Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc., Novo Nordisk A/SInventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, Morten Revsgaard Frederiksen, Mikkel Oliver Jespersen, Brian Mouridsen, Jesper Windum, Mette Poulsen, Brian Jensen, Jorrit Jeroen Water, Mikkel Wennemoes Hvitfeld Ley, Xiaoya Lu
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Publication number: 20200230324Abstract: An add-on device adapted to be releasably mounted on a drug delivery device, the add-on device comprising an outer assembly with an add-on dose setting member adapted to be coupled to the outer housing of a pen housing, as well as an inner assembly engaging the pen dose setting member and being in rotational engagement with the add-on dose setting member during dose setting. The invention addresses the issue of preventing transfer of movement from the add-on dose setting member to the inner assembly during dose expelling, which in accordance with the invention is realized by rotationally de-coupling the inner and outer assembly during dose expelling.Type: ApplicationFiled: September 21, 2018Publication date: July 23, 2020Inventors: Bennie Peder Smiszek Pedersen, Brian Mouridsen, Jesper Hoeholt, Steven Linnebjerg, Lars Morten Bom
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Patent number: 9950118Abstract: The present invention relates to an injection device (1) for setting and injecting set doses from a held drug cartridge (10). The injection device (1) comprises a housing (110,120,130, 140), a piston rod (800), a rotatable driver (500, 700) and a dose setting device (400). The dose setting device (400) comprises a predetermined stop to limit the amount of an expelled dose corresponding to the amount of a set dose. A secondary stop limiter includes first (700) and second (270) components and a secondary stop track follower (950) arranged between the first (700) and second (270) components. If the predetermined stop fails to stop the driver (500, 700) at the end of injection, the secondary stop track follower (950) moves towards a safety stop (708) to prevent the driver (500, 700) from rotating further.Type: GrantFiled: March 15, 2013Date of Patent: April 24, 2018Assignee: Novo Nordisk A/SInventors: Bastian G. Kjeldsen, Brian Mouridsen, Jim Radmer
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Patent number: 9901683Abstract: The present invention relates to an injection device (1) for setting and injecting set doses from a held drug cartridge (10). The injection device (1) comprises a housing (110, 120, 130, 140), a piston rod (800), a rotatable driver (500, 700) and a dose control member (350). A stored energy source (560) is configured to drive rotation of the driver (500, 700) to cause the piston rod (800) to expel a set dose. The dose control member (350) rotates during dose setting and during dose expelling. A first clutch (C1) is arranged between the dose control member (350) and the driver (500, 700). A second clutch (C2) is arranged between the driver (500, 700) and the housing (110, 120, 130, 140) to control the expelling movement. During dose setting the first clutch (C1) is disengaged and the second clutch (C2) is engaged. During dose expelling the first clutch (C1) is engaged and the second clutch (C2) is disengaged.Type: GrantFiled: March 15, 2013Date of Patent: February 27, 2018Assignee: Novo Nordisk A/SInventors: Bastian G. Kjeldsen, Brian Mouridsen
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Patent number: 9604007Abstract: The present invention relates to a medical injection system comprising a medical injection device (100) of the type comprising a rotatable dose setting member (160). The system further comprises a dose limiter module (200) adapted for being releasably coupled to the injection device (100). The dose limiter module (200) comprises a dose limiter base (201) and a limiter (240) arranged relative to the dose limiter base (201) so that their relative position is adjustable to set an adjusted dose limiting position. When the dose limiter module (200) is coupled to the injection device (100), the limiter (240) cooperates with the dose setting member (160) to define a blocking means for preventing rotation of the dose setting member (160) beyond the adjusted dose limiting position.Type: GrantFiled: November 8, 2012Date of Patent: March 28, 2017Assignee: Novo Nordisk A/SInventors: Bastian Gaardsvig Kjeldsen, Brian Mouridsen
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Patent number: 9586007Abstract: The present invention relates to an injection device for automatic torsion spring driven injection of a liquid drug. The injection device is of the type wherein a telescopically movable needle shield (20) activates the release of the torque of the torsion spring to drive the injection when the needle shield is moved from its extended position to a retracted position. The injection device is provided with a needle interface (30) carrying the injection needle, which needle interface is provided with means (32) preventing axial movement of the shield when no injection needle is mounted. Further, other means are provided to restrain the needle shield in the retracted position when the injection device is its “zero” position such that a user has access to the injection needle in order to exchange the injection needle.Type: GrantFiled: June 25, 2013Date of Patent: March 7, 2017Assignee: Novo Nordisk A/SInventors: Simon Roervig, Steffen Hansen, Simon Munch Pedersen, Brian Mouridsen
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Publication number: 20160317745Abstract: The present invention relates to an auto-injection device (100) repeatedly activateable for automatically expelling multiple set doses of a liquid drug. An activation button (190) protrudes from a proximal end of a housing (101) and is axially moveable between an activateable position and an activated position. The auto-injection device includes dose setting means comprising a dose setting device (170) that performs a helical movement away from a zero dose position during setting of a dose and returns by a helical movement to the zero dose position as the set dose is expelled. The dose setting device (170) is coupled to the activation button (190) to retain the activation button in the activated position when the dose setting device (170) assumes its zero dose position.Type: ApplicationFiled: January 5, 2015Publication date: November 3, 2016Inventors: Bastian Gaardsvig Kjeldsen, Brian Mouridsen