Patents by Inventor Brian Murphy

Brian Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10376588
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: August 13, 2019
    Assignee: Coherus Biosciences, Inc.
    Inventors: Mark Manning, Brian Murphy
  • Patent number: 10363558
    Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: July 30, 2019
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Ivor T. Knight, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
  • Publication number: 20190216930
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions stabilized with an amino acid and suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: March 21, 2019
    Publication date: July 18, 2019
    Applicant: COHERUS BIOSCIENCES, INC.
    Inventors: Mark MANNING, Brian MURPHY
  • Publication number: 20190184017
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark MANNING, Brian Murphy
  • Patent number: 10301143
    Abstract: A tether guide operable through a wide range of tether/fleeting angles while causing minimal wear and having a reduced size compared to a levelwind wheel. The tether guide may include a series of rollers approximating the curved shape and radius of levelwind wheel. The tether guide may include downward facing guide wings matched to a curved roller profile, but flaring out to capture and guide tether into rollers. Sensors may be included on the tether guide to provide information about tether location, including whether the tether is engaged in the tether guide.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: May 28, 2019
    Assignee: Makani Technologies LLC
    Inventors: Abhimanyu Belani, Elias Patten, Robert Nelson, Brian Hachtmann, Gabriel Murphy
  • Publication number: 20190153389
    Abstract: Provided herein are methods of treating acute myeloid leukemia (AML) and multiple myeloma (MM) by administering an effective amount of a cell population comprising natural killer cells, wherein the cell population comprising natural killer cells is produced by a three-stage method comprising culturing a population of hematopoietic stem or progenitor cells in media comprising stem cell mobilizing factors, e.g., three-stage methods of producing NK cells in media comprising stem cell mobilizing factors starting with hematopoietic stem or progenitor cells from cells of the placenta, for example, from placental perfusate (e.g., human placental perfusate) or other tissues, for example, umbilical cord blood or peripheral blood. Further provided herein are methods of using the NK cells produced by the three-stage methods provided herein to suppress the proliferation of acute myeloid leukemia cells.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 23, 2019
    Applicant: CELULARITY, INC.
    Inventors: Steven A. FFISCHKOFF, Uri HERZBERG, Lin KANG, Brian MURPHY, Andrea NORDBERG, Vanessa VOSKINARIAN-BERSE, Keith WILSON, Xiaokui ZHANG, Han MYINT, Mohamed HUSSEIN
  • Publication number: 20190152676
    Abstract: Provided herein are devices and methods for thawing frozen biological material.
    Type: Application
    Filed: June 18, 2018
    Publication date: May 23, 2019
    Applicant: CELULARITY, INC.
    Inventor: Brian Murphy
  • Patent number: 10299000
    Abstract: Embodiments of mechanisms for dynamic media content type streaming management for mobile devices are generally described herein. In some embodiments, the mobile device may receive selection input pertaining to generating output from a media file containing at least two of audio data, video data, and closed-captioning data, the selection input selecting at least one of audio, video, and closed-captioning to be output during play of the media content. In some embodiments, the mobile device may generate an audio output as a signal in response to the selection input including audio. In some embodiments, the mobile device may generate a video output as a signal in response to the selection input including video. In some embodiments, the mobile device may generate a closed-captioning output as a signal in response to selection input including closed-captioning.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: May 21, 2019
    Assignee: Intel Corporation
    Inventors: Gyan Prakash, Rajesh Poornachandran, Brian J. Hernacki, Kaitlin Murphy, Rita H. Wouhaybi
  • Patent number: 10293049
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions stabilized with an amino acid and suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: May 21, 2019
    Assignee: Coherus Biosciences, Inc.
    Inventors: Mark Manning, Brian Murphy
  • Patent number: 10287354
    Abstract: Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 14, 2019
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Jennifer Brogdon, Boris Engels, David Jonathan Glass, Brian Granda, John Hastewell, Andreas Loew, Joan Mannick, Michael Milone, Leon Murphy, William Raj Sellers, Huijuan Song, Brian Edward Vash, Jan Weiler, Qilong Wu, Li Zhou
  • Patent number: 10213508
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: February 26, 2019
    Assignee: Coherus BioSciences, Inc.
    Inventors: Mark Manning, Brian Murphy
  • Patent number: 10206807
    Abstract: A patient transfer device is utilized to transport infant patients between locations within a hospital environment. The patient transfer device includes a center, support section and a pair of side sections that can be moved into contact with each other to surround the infant patient. The first and second side sections each include a handle that can be brought into close proximity to each other and can be grasped by a single hand of a clinician. The patient transfer device includes a stiffening device that is positioned within the center section to provide support for the infant patient during transport. A hold down device is included on one or both of the first and second side sections to securely hold tubes and wires connected to the infant patient during transport of the infant patient.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: February 19, 2019
    Assignee: General Electric Company
    Inventors: Karen P. Starr, Alexander Flamm, Brian Murphy, Erik Askin
  • Patent number: 10172732
    Abstract: A prosthesis delivery handle with a bushing (66) with two adjacent internal threads (64, 74) with different diameters and pitch surrounding a tubular threaded first shaft member (36) cooperating with the first thread (64) and a second inner member with a protrusion (82) extending through an axial slot in the tubular first member such that the protrusion runs in the second thread (74). First and second members are connected to an external shaft (112) and an internal element (102) so that when the bushing is rotated first and second members travel axially with different speeds the internal shaft and an external shaft move accordingly.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: January 8, 2019
    Assignee: Biotronik AG
    Inventors: Brian Murphy, Markus Hepke
  • Patent number: 10104880
    Abstract: Provided herein are improved methods for the formulation of compositions comprising placental stem cells, and improved compositions and cell formulations produced thereby.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: October 23, 2018
    Assignee: CELULARITY, INC.
    Inventors: Andy Zeitlin, Gregory Russotti, Shuyang He, Ajai Pal, Hong J. Chen, Thomas Brieva, Ryan Shorr, Brian Murphy
  • Patent number: 10092902
    Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: October 9, 2018
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
  • Patent number: 10076316
    Abstract: A device for needle biopsy is provided. The device includes a handle member having proximal and distal portions. A proximal handle member is disposed to the proximal portion of the handle member and a distal handle member is disposed to the distal portion of the handle member. A sheath lumen is disposed within the handle member and extends from the distal portion of the handle member. A needle housing member is partially disposed to the proximal portion of the handle member and a needle is disposed within the sheath lumen. A plurality of protrusions are disposed upon the needle.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: September 18, 2018
    Assignee: COVIDIEN LP
    Inventors: John Mugan, Brian Murphy, John O. McWeeney
  • Publication number: 20180235585
    Abstract: A device for needle biopsy is presented. The device includes a handle member having proximal and distal portions. A proximal handle member is disposed to the proximal portion of the handle member and a distal handle member is disposed to the distal portion of the handle member. A sheath lumen is disposed within the handle member and extends from the distal portion of the handle member. A needle housing member is partially disposed to the proximal portion of the handle member and a needle is disposed within the sheath lumen. A plurality of protrusions is disposed upon the needle. A needle protection member is partially disposed to the distal portion of the needle housing member. The needle protection member includes a needle protection hub and a needle protection shaft.
    Type: Application
    Filed: February 1, 2018
    Publication date: August 23, 2018
    Inventors: John MUGAN, Brian MURPHY, John MCWEENEY
  • Publication number: 20180205417
    Abstract: A wireless charging system for a wearable sensor device can include a wireless charging device and a user device. The wireless charging device can include a transmitter for sending a power signal to charge the wearable sensor device, a first receiver to receive a data signal and a second to receive a low energy signal. The wearable sensor device can include at least one memory for storing sensor data, a first receiver for receiving the power signal from the wireless charging device, a first transmitter to transmit a data signal and a second receive to receive a low energy signal. The user device can include a low energy transmitter for communicating with the wireless charging device and sensor device to control the charging function and the data communication function of the wireless charging device to selectively charge and transfer data with wearable sensor device.
    Type: Application
    Filed: August 14, 2017
    Publication date: July 19, 2018
    Inventors: Milan Raj, Bryan McGrane, Valerie Susan Hanson, Brian Murphy, Emily Plumb
  • Patent number: D855191
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: July 30, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ji Hyung(Suzy) Hong, Brian Murphy, Derek Verhoorn
  • Patent number: D855930
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: August 13, 2019
    Assignee: Morton Salt, Inc.
    Inventors: Marcy Barson, Brody Boyer, Lucy Flanagan, Brian Grindley, Ellen Kellogg, Thorsten Köpp, Evelyne Michel, Shannon Murphy Rodenberg, Jacob Taylor