Abstract: The invention generally relates to detecting the presence of a pathogen in a sample, specifically severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and physiological effects on the host with prognostic value, by methods that can simultaneously detect the pathogen and a host's transcriptional response to infection by the pathogen.

Abstract: A handheld, lightweight pole that telescopically extends a substantial length that terminates at a hook. The hook allows the user to attach the pole securely to the ridge. A plurality of rungs is spaced along the pole, wherein each rung acts as a step or handle to help the user climb safely. Each hung may be selectively positioned along the pole.

Abstract: A method for calculating a crane capacity for a crane having a variable position counterweight at a locked position includes determining a boom combination and determining a maximum capacity at a hook position for the boom combination. A maximum target value for an operating condition dependent on a balance of the crane is determined. An indication of the locked counterweight position is received. At least one new target value for the operating condition dependent on the balance of the crane between the variable position counterweight at the locked counterweight position is established. A new capacity of the crane is calculated by decrementing the maximum capacity of the crane proportionally to a difference in the maximum target value and the at least one new target value. Cranes and crane control systems may employ this method.

Abstract: Valve assembly for a pump, the valve assembly including: a valve seat having a valve face (60), a flexible valve having a sealing portion for abutting the valve face (60), and at least a fluid pathway (66, 68, 70) from an interior of the valve seat to an exterior of the valve seat that serves as a leak flow path for fluid when the valve is in the closed position to reduce pressure build up on the valve. In this way, the vacuum inside the pump can be released when the value is in the closed position and the pump is stopped, thereby allowing the pump to start/restart due to reduced pressure build up on a side of the valve abutting the valve face. A pump or compressor including such a valve assembly is also disclosed.

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups A and B are defined herein, which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups A and B are defined herein, which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract: A method for calculating a crane capacity for a crane having a variable position counterweight at a locked position includes determining a boom combination and determining a maximum capacity at a hook position for the boom combination. A maximum target value for an operating condition dependent on a balance of the crane is determined. An indication of the locked counterweight position is received. At least one new target value for the operating condition dependent on the balance of the crane between the variable position counterweight at the locked counterweight position is established. A new capacity of the crane is calculated by decrementing the maximum capacity of the crane proportionally to a difference in the maximum target value and the at least one new target value. Cranes and crane control systems employing the method are also disclosed.

Abstract: A system and method for calculating a crane capacity for a crane having a variable position counterweight at an intermediate position is disclosed. In the method a boom combination is determined and a maximum capacity at a hook position is determined for the boom combination. A target value for an operating condition is established dependent on a balance of the crane between the variable position counterweight and a load on the hook. An indication is received of an intermediate counterweight position, and a load is calculated for the hook at the hook position for the boom combination and the intermediate counterweight position that results in the operating condition having the target value to determine an intermediate capacity. The intermediate capacity is compared with the maximum capacity and the lower of the maximum capacity and the intermediate capacity is output.

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups A and B are defined herein, which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract: A system and method for calculating a crane capacity for a crane having a variable position counterweight at an intermediate position is disclosed. In the method a boom combination is determined and a maximum capacity at a hook position is determined for the boom combination. A target value for an operating condition is established dependent on a balance of the crane between the variable position counterweight and a load on the hook. An indication is received of an intermediate counterweight position, and a load is calculated for the hook at the hook position for the boom combination and the intermediate counterweight position that results in the operating condition having the target value to determine an intermediate capacity. The intermediate capacity is compared with the maximum capacity and the lower of the maximum capacity and the intermediate capacity is output.

Abstract: A system and method for positioning a movable crane counterweight is disclosed. In the method, a boom orientation is determined, a first counterweight position is determined, a first crane capacity at the first counterweight position is determined, a second counterweight position is determined corresponding to a second rearward stability associated with the boom orientation. A second crane capacity at the second counterweight position. A load on the crane is determined and the counterweight is positioned at a third position between the first counterweight position and the second counterweight position dependent on the boom load, and the first crane capacity.

Abstract: The present invention encompasses compounds of the formula (I): wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: A system and method for positioning a movable crane counterweight is disclosed. In the method, a boom orientation is determined, a first counterweight position is determined, a first crane capacity at the first counterweight position is determined, a second counterweight position is determined corresponding to a second rearward stability associated with the boom orientation. A second crane capacity at the second counterweight position. A load on the crane is determined and the counterweight is positioned at a third position between the first counterweight position and the second counterweight position dependent on the boom load, and the first crane capacity.

Abstract: The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: Valve assembly for a pump, the valve assembly including: a valve seat having a valve face (60), a flexible valve having a sealing portion for abutting the valve face (60), and at least a fluid pathway (66, 68, 70) from an interior of the valve seat to an exterior of the valve seat that serves as a leak flow path for fluid when the valve is in the closed position to reduce pressure build up on the valve. In this way, the vacuum inside the pump can be released when the value is in the closed position and the pump is stopped, thereby allowing the pump to start/restart due to reduced pressure build up on a side of the valve abutting the valve face. A pump or compressor including such a valve assembly is also disclosed.

Abstract: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.

Abstract: An ultrasonic transducer includes a wear plate (2), a piezoelectric element (8) arranged rearwards of the wear plate and a rigid block (16) arranged rearwards of the piezoelectric element and configured to provide a backing mass for the piezoelectric element. The wear plate extends across the piezoelectric element and rearwards so as to provide a cap over the piezoelectric element and sides of at least a forward portion of the rigid block.

Abstract: Disclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1, X and G are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

Abstract: Disclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1-R3, X and L are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).