Abstract: The present invention provides a method of inhibiting cancer growth in the lungs of a mammal through the inhalation administration of aerosol particles of an anti-cancer drug formulation. Further, the present invention provides a formulation for aerosol delivery that comprises a combination of paclitaxel, ?-tocopheryl succinate; sorbitan trioleate, ethanol, and carbon dioxide. Prior studies have indicated that aerosol administration of cancer drugs holds great potential as a treatment modality, both for lung cancer and for lung metastases of other cancers. Practice of the invention has been demonstrated using a mouse model of lung cancer, in which intrapulmonary deposition of paclitaxel by aerosol inhalation reduced lung tumor size and increased body weight in tumor-bearing mice.

Abstract: Apparatus for pressure processing components is disclosed which includes an improved closure system that minimizes dust-generating parts and allows easy access to the chamber. Ports are provided for introducing and releasing pressurized gases and fluids to and from the processing space. The heating system of the apparatus heats both the cover and the stage inside the pressurized chamber such that cycle time to equilibrate heated, pressurized fluids such as supercritical carbon dioxide inside the chamber are decreased. The apparatus includes a mechanism that raises the stage inside the chamber, pressing it against the fixed cover and sealing the inside of the pressure vessel. In one embodiment a screw-type jack is used to move the component-loaded stage fitted with a deformable o-ring seal a short travel distance to seat against the lid and seal the pressure chamber. In a related embodiment a computer and an electronic stepper motor are used to drive the pressing means in an automated fashion.

Abstract: Apparatus for pressure processing components is disclosed which includes an improved closure system that minimizes dust-generating parts and allows easy access to the chamber. Ports are provided for introducing and releasing pressurized gases and fluids to and from the processing space. The heating system of the apparatus heats both the cover and the stage inside the pressurized chamber such that cycle time to equilibrate heated, pressurized fluids such as supercritical carbon dioxide inside the chamber are decreased. The apparatus includes a mechanism that raises the stage inside the chamber, pressing it against the fixed cover and sealing the inside of the pressure vessel. In one embodiment a screw-type jack is used to move the component-loaded stage fitted with a deformable o-ring seal a short travel distance to seat against the lid and seal the pressure chamber. In a related embodiment a computer and an electronic stepper motor are used to drive the pressing means in an automated fashion.

Abstract: A method to maintain magnetic levitation that is stabilized by means of Hall effect sensors is disclosed. The method and device comprising a Hall effect sensor or sensors used to control an electromagnet to maintain the position between two magnets or objects. The present invention has been used to suspend a magnet in a high pressure tube that is magnetically coupled to a magnet outside the tube connected to an analytical balance that can accurately measure the force on the magnet inside the tube. This force measurement can be used to determine fluid density, flow, viscosity, and solubility. This magnetic levitation method also has application for other devices such as motors, generators, trains, turbines, wind tunnels, and entertainment devices.

Abstract: A method to maintain magnetic levitation that is stabilized by means of Hall effect sensors is disclosed. The method and device comprising a Hall effect sensor or sensors used to control an electromagnet to maintain the position between two magnets or objects. The present invention has been used to suspend a magnet in a high pressure tube that is magnetically coupled to a magnet outside the tube connected to an analytical balance that can accurately measure the force on the magnet inside the tube. This force measurement can be used to determine fluid density, flow, viscosity, and solubility. This magnetic levitation method also has application for other devices such as motors, generators, trains, turbines, wind tunnels, and entertainment devices.