Abstract: Methods and systems are provided to obtain a clinically meaningful characterization of T cell receptor (TCR) or B cell receptor (BCR) repertoire using cell-free-DNA or immune cell-derived DNA.

Abstract: An aircraft-based system for providing forward-looking terrain profiling and downward-looking altimetry via a single active electronically scanned array (AESA) orients the AESA through a sequence of desired directions, e.g., according to a predetermined scan pattern. At each desired direction, the AESA scans for ground-based targets, determining a range and Doppler velocity to each detected target. The AESA additionally orients downward, e.g., during a dedicated altimetry frame and with the assistance of inertial sensors to determine the orientation of the AESA, to scan terrain directly below the aircraft and provide a precise estimate of the altitude of the aircraft. Based on the determined ranges and velocities, the radar system determines a pointing angle and vertical/horizontal distances between the aircraft and each identified ground-based target.

Abstract: The present invention broadly comprises crowd-sourced computer-implemented methods and systems of collecting and transforming portable device data. One embodiment of the invention may be implemented as a system including an electronic device including a sensor configured to collect data, the device configured to begin collection of data based on a command from a user of the electronic device; and a server configured to issue a command to the electronic device to turn on the sensor and transmit data collected by the sensor to the server without any input by the user of the electronic device when a condition is met.

Abstract: A device for connecting and transferring contents between a surgically created first orifice and a surgically created second orifice is provided. The device comprises a hollow body member and first and second tubular legs depending from the hollow body, and being adapted for insertion into the first and second surgically created orifices respectively. The device further comprises a cap for closing the hollow body and completing a sealed pathway between the tubular legs for passively conveying contents between the first and second surgically created orifices. Sealing features of the device are provided that in combination operate to keep the contents away from unwanted skin areas and/or provide an easy-to-use device.

Abstract: A method of target enrichment or depletion from a sample with an analyte is described. A probe has one of a left-handed PNA pair and a targeting moiety, in which the left-handed PNA pair are a complementary pair of PNAs that are chiral and have a cyclic backbone modification that induces a left-handed helical structure. A capture surface has the other of the left-handed PNA pair; and the left-handed PNA pair bind to hybridize the probe to the capture surface, which may be a magnetic bead.

Abstract: A regular expression prompt may be determined by combining a regular expression prompt template with input text from an input document. The regular expression prompt template may include a natural language instruction to identify one or more regular expressions from the input text and one or more fillable portions designated for filling with the input text. The regular expression prompt may be sent to a large language model for evaluation, and one or more regular expressions may be identified based on a response received from the large language model. The regular expressions may be used to disaggregate the input text, and the disaggregated text portions may be used to determine a structured document based on the input document. The structured document may be used to determine a response to a query of the input document.

Abstract: The present invention broadly comprises crowd-sourced computer-implemented methods and systems of collecting and transforming portable device data. One embodiment of the invention may be implemented as a system including an electronic device including a sensor configured to collect data, the device configured to begin collection of data based on a command from a user of the electronic device; and a server configured to issue a command to the electronic device to turn on the sensor and transmit data collected by the sensor to the server without any input by the user of the electronic device when a condition is met.

Abstract: Exemplary processes for converting one or more oxygenates to one or more olefins are disclosed. In one exemplary aspect, the process can include introducing a first input feed into an adiabatic multistage reactor with a first reactor bed and a second reactor bed. The process can also include contacting the first input feed with the first reactor bed to maintain a first temperature of the first reactor bed within a first temperature range and to produce a first reaction mixture, and introducing a second input feed into the multistage reactor such that the first reaction mixture is mixed with the second input feed to produce a first effluent. The process can also include contacting the first effluent with the second reactor bed to thereby maintain a second temperature of the second reactor bed within a second temperature range and to produce a second reaction mixture. Exemplary systems are also disclosed.

Abstract: Nucleic acid molecules and compositions thereof targeted to fidgetin-like 2, and methods of their use in treating a wound or scar in a human subject are described.

Abstract: Relevance scores may be determined based on text included in a document. The text may be divided into a text portions, with the relevance scores being determined based on a comparison of a text portion of the plurality of text portions with a criterion specified in natural language. A subset of the plurality of text portions may be selected based on the plurality of relevance scores, with each of the subset of the plurality of text portions having a relevance score surpassing a threshold. A criteria evaluation prompt may be sent to a remote text generation modeling system via a communication interface. The criteria evaluation prompts may include an instruction to evaluate one or more of the subset of text portions against the criterion.

Abstract: A method of target enrichment or depletion from a sample with an analyte is described. A probe has one of a left-handed PNA pair and a targeting moiety, in which the left-handed PNA pair are a complementary pair of PNAs that are chiral and have a cyclic backbone modification that induces a left-handed helical structure. A capture surface has the other of the left-handed PNA pair; and the left-handed PNA pair bind to hybridize the probe to the capture surface, which may be a magnetic bead.

Abstract: There are provided high power laser perforating tools and methods of delivering laser energy patterns that enhance the flow of energy sources, such as hydrocarbons, from a formation into a production tubing or collection system. These tools and methods precisely deliver predetermined laser beam energy patterns, to provide for custom geometries in a formation. The patterns and geometries are tailored and customized to the particular geological and structural features of a formation and reservoir.

Abstract: Disclosed herein are macrolide compounds with ATP synthase inhibitory activity. The macrolides may be used to treat cancer and other proliferative disorders. The macrolides may be used to treat leukemia, including acute myeloid leukemia. The macrolides may be used to treat cancer, including AML, in a patient that has developed multidrug resistance. In some embodiments, the macrolide is a derivative of ammocidin A.

Abstract: A system and method for determining the changes in resonance frequency in crystal microbalance (CM) sensors and the resulting changes in the determination of incremental mass on the CM sensors caused by temperature. Dual mode resonances and coefficients are used in a deconvolution process to determine and extract the frequency shift caused by temperature to provide the temperature compensated incremental mass (?M). In one embodiment, dual mode analysis is provided using a mass mode (e.g., the c-mode fundamental frequency (fc100)) and a temperature mode (e.g., the anharmonic frequency (fc102)) and associated coefficients. In other embodiments that are more sensitive to temperature changes, dual mode analysis is provided using the b-mode fundamental frequency (fb100) as the temperature-mode and associated coefficients.

Abstract: Embodiments include apparatuses for rebooting an electronic device. In an embodiment, an apparatus includes a data interface, a first power port, a second power port, a switch, and a processor. The data interface is configured to connect to the electronic device. The first power port is configured to receive power from a power source and the second power port is configured to deliver power to the electronic device. The switch is configured to connect the first power port to the second power port. The processor conducts data communications monitoring of the electronic device via the data interface and reboots the electronic device responsive to the data communications monitoring.

Abstract: A portable diagnostic device has a lysate stage (167) with a port for receiving a sample and containing magnetic beads with a probe, and an outlet port. A series of assay stages (161-164) are linked with the lysate vessel, each with a reservoir linked by channels. The final stage (164) has a sensor (169) for detecting beads attached to analyte molecules which have been conveyed according to attachment to probes on beads. Larger transport beads cause reporter beads which are tethered by target NA and probes to be transported to the final sensor stage, where they are released and detected when the transport beads have been removed.

Abstract: An improved feeding catheter is provided for feeding/recycling chyme to a distal stoma. The improved catheter includes a hollow tube having an end for insertion into stoma, and a second end adapted to be connected to a fluid source. The first end includes a retention feature comprising a plurality of ribs extending outwardly and longitudinally away from the tube and terminating at a nose junction. Web walls extend between at least one pair of adjacent ribs and the ribs further define a side facing opening configured for fluid to exit into the gastrointestinal tract. Further the retention feature can be moved between a relaxed condition and a stretched condition for insertion through the distal opening, wherein the maximum width of the retention feature in the stretched condition is less than the maximum width of the retention feature in the relaxed condition.

Abstract: A data processing system includes a transaction bus, a console application in communication with the transaction bus, and a view predictor subsystem in communication with the transaction bus. The transaction bus receives, from a user application executing on a client device, a call for visual information to be provided to the user application. The view predictor subsystem determines a likelihood that the visual information will be viewable within a viewport of the user application, and a plurality of respective values for a plurality of sources of the visual information are computed based on the likelihood and a respective priority for each source. The console application provides to the transaction bus the set of potential sources of the visual information, and the transaction bus selects, based on the computed values, one of the potential sources of the visual information to be the result, which is provided to the user application.

Abstract: Relevance scores may be determined based on text included in a document. The text may be divided into a text portions, with the relevance scores being determined based on a comparison of a text portion of the plurality of text portions with a criterion specified in natural language. A subset of the plurality of text portions may be selected based on the plurality of relevance scores, with each of the subset of the plurality of text portions having a relevance score surpassing a threshold. A criteria evaluation prompt may be sent to a remote text generation modeling system via a communication interface. The criteria evaluation prompts may include an instruction to evaluate one or more of the subset of text portions against the criterion.