Abstract: The invention relates to a pharmaceutical formulation comprising nicotine. The formulation can be aerosolised at ambient temperature for delivery via inhalation. The invention also relates to a method of delivering nicotine to a subject via inhalation, and specifically via the use of a nebuliser.

Abstract: The invention relates to a pharmaceutical formulation comprising nicotine. The formulation can be aerosolised at ambient temperature for delivery via inhalation. The invention also relates to a method of delivering nicotine to a subject via inhalation, and specifically via the use of a nebuliser.

Abstract: Methods of enhancing skin health recovery from a skin procedure comprising laser application to the skin using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid.

Abstract: Methods of accelerating or improving the healing of a skin graft or skin grafting site in a subject are provided comprising administering to the subject an amount of an inhibitor of fidgetin-like 2.

Abstract: Methods and compositions for reducing a ratio of collagen III to collagen I in wounded skin, treating wounds and accelerating healing is provided with a surfactant polymer dressing comprising FL2 siRNA, collagen and a poloxamer.

Abstract: Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.

Abstract: An air filter assembly for a bicycle is disclosed. The air filter assembly includes a body having a bracket and a frame. The bracket is configured to mount to a bicycle frame. The frame defines a tapered opening having a windward side and a leeward side. The tapered opening is larger on the windward side than on the leeward side. A removable air filter cartridge is mounted within the opening of the frame such that a force acting on the air filter cartridge on the windward side tends to wedge the air filter cartridge in the opening. A foam member is attached to an outer periphery of the air filter cartridge and is disposed between the air filter cartridge and the frame. The foam member is compressible so as to hold the air filter cartridge in the opening of the frame. The foam member compresses to a greater degree on the leeward side of the opening than on the windward side of the opening. The air filter assembly is mountable to a handle bar of a bicycle.

Abstract: The invention relates to a pharmaceutical formulation comprising nicotine. The formulation can be aerosolised at ambient temperature for delivery via inhalation. The invention also relates to a method of delivering nicotine to a subject via inhalation, and specifically via the use of a nebuliser.

Abstract: Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.

Abstract: Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.

Abstract: Methods of enhancing skin health recovery from a skin procedure comprising laser application to the skin using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid.

Abstract: The disclosure provides methods of enhancing hair growth and hair follicle restoration using a siRNA or shRNA directed against a human Fidgetin like-2 nucleic acid. Specifically, the disclosure provides compositions comprising siRNA or shRNA against a human Fidgetin like-2 nucleic acid, and the methods of using the compositions. Further disclosed are siRNA sequences against a human Fidgetin like-2 nucleic acid and the formulations of the compositions.

Abstract: Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing, treating fibrosis, reducing scarring and treating nerve pain.

Abstract: The invention provides a submersible or harsh environment connector for use with electrical, optical or electro-optical cables having first and second connector units which are releasably mateable and that are not pressure compensated. The invention provides a wet-mate without pressure balancing system for making a subsea wet-mate connection. The invention uses a reservoir of fluid and a mechanism energized by mating, such as by a spring, to push that fluid into a small mated connection, discharging an equivalent volume of seawater and creating electrical and/or optical continuity. One-way or back-flow prevent valves ensure there is no return flow of seawater. Typical fluids would be dielectric oil or optical gel.

Abstract: Interactive systems and methods for creating game and game-like applications, including a direct challenge application for building a head-to-head challenge between users, are presented. A system for building and managing a plurality of direct challenges includes an application services interface, a plurality of user interfaces, a challenge application, and a plurality of external data services for tracking the progress and player performance during real-world events, such as sporting events.

Abstract: Interactive systems and methods for creating game and game-like applications, including a direct challenge application for building a head-to-head challenge between users, are presented. A system for building and managing a plurality of direct challenges includes an application services interface, a plurality of user interfaces, a challenge application, and a plurality of external data services for tracking the progress and player performance during real-world events, such as sporting events. Also disclosed is a system and methods allowing a user to change or modify their fantasy player lineup during the progress of a live action sporting event.

Abstract: The invention provides a submersible or harsh environment connector for use with electrical, optical or electro-optical cables having first and second connector units which are releasably mateable and that are not pressure compensated. The invention provides a wet-mate without pressure balancing system for making a subsea wet-mate connection. The invention uses a reservoir of fluid and a mechanism energized by mating, such as by a spring, to push that fluid into a small mated connection, discharging an equivalent volume of seawater and creating electrical and/or optical continuity. One-way or back-flow prevent valves ensure there is no return flow of seawater. Typical fluids would be dielectric oil or optical gel.

Abstract: A receptacle for receiving fastening elements for connection of two components of a unit to be assembled, the receptacle has means for providing a separate reception of different fastening elements which differ from one another with regard to a shape, and/or a size, and/or a material, such that different ones of the fastening elements with which the receptacle is charged are coordinated with the components which are respectively to be connected, and a number of the fastening elements to be received by the receptacle corresponds at least to a number of connection sites on the components.

Abstract: Methods and compounds for preventing or reducing the toxic side effects of cardiac glycosides by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) are provided. Methods and compositions for preventing or reducing the occurrence of conditions associated with heart failure, including, but not limited to, sudden cardiac death and contractile decompensation, by inhibiting the mNCE also are provided.

Abstract: A night vision system includes an image sensor and circuitry coupled to a digital storage medium or transmitter that periodically samples a signal provided by the image sensor and stores the sampled image to be viewed in near real time or at a later date by a data analyst. The night vision system includes an imaging assembly with a casing surrounding an image intensifier and the associated circuitry along with a port for accepting a power and/or signal cable for providing power to the image assembly and image signal data to the digital storage medium. The system may further include a daytime camera and a switch for toggling the image signal data input to the digital storage medium between the daytime camera and the low light image sensor, as well as a transmission system for wirelessly transmitting signals.