Patents by Inventor BRIAN P. GEORGE
BRIAN P. GEORGE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240032841Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.Type: ApplicationFiled: October 10, 2023Publication date: February 1, 2024Inventors: PING JIA, CHARULATHA RAMANATHAN, MARIA STROM, BRIAN P. GEORGE, LALITA BHETWAL, HAROLD WODLINGER, JONATHAN D. SMALL
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Patent number: 11826148Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.Type: GrantFiled: December 6, 2021Date of Patent: November 28, 2023Assignee: CARDIOINSIGHT TECHNOLOGIES INC.Inventors: Ping Jia, Charulatha Ramanathan, Maria Strom, Brian P. George, Lalita Bhetwal, Harold Wodlinger, Jonathan D. Small
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Publication number: 20220160307Abstract: Systems and methods are described herein for estimating and filtering electrophysiological signals. In some examples, a noise filtering system can be employed to receive at least one electrophysiological signal. A signal segment extractor of the system can extract a signal segment of interest from the electrophysiological signal. The system employs a signal segment noise calculator to evaluate the extracted signal segment of interest to estimate a noise in the signal segment of interest. The estimated noise can be provided to a signal segment filter of the system to determine a surrogate noise estimate for at least one remaining signal segment of the electrophysiological signal for noise filtering the at least one remaining signal segment. The signal segment noise calculator can be configured to filter the signal segment of interest based on the estimated noise and the filtered signal segments can be combined to provide a filtered electrophysiological signal.Type: ApplicationFiled: June 9, 2021Publication date: May 26, 2022Inventors: QINGGUO ZENG, JEFFREY B. ADAIR, BRIAN P. GEORGE, QING LOU, TIMOTHY G. LASKE
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Patent number: 11284830Abstract: An example method includes analyzing morphology and/or amplitude of each of a plurality of electrophysiological signals across a surface of a patient's body to identify candidate segments of each signal satisfying predetermined conduction pattern criteria. The method also includes determining a conduction timing parameter for each candidate segment in each of the electrophysiological signals.Type: GrantFiled: January 28, 2020Date of Patent: March 29, 2022Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qing Lou, Meredith E. Stone, Qingguo Zeng, Jeffrey B. Adair, Connor S. Edel, Ping Jia, Kevin R. Ponziani, Brian P. George, Ryan M. Bokan, Matthew J. Sabo, Vladimir A. Turovskiy, Ketal C. Patel, Charulatha Ramanathan
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Publication number: 20220087589Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.Type: ApplicationFiled: December 6, 2021Publication date: March 24, 2022Inventors: PING JIA, CHARULATHA RAMANATHAN, MARIA STROM, BRIAN P. GEORGE, LALITA BHETWAL, HAROLD WODLINGER, JONATHAN D. SMALL
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Patent number: 11224374Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.Type: GrantFiled: December 20, 2016Date of Patent: January 18, 2022Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Ping Jia, Charulatha Ramanathan, Maria Strom, Brian P. George, Lalita Bhetwal, Harold Wodlinger, Jonathan D. Small
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Publication number: 20210100466Abstract: This disclosure relates to integrated channel integrity detection and to reconstruction of electrophysiological signals. An example system includes a input channels configured to receive respective electrical signals from respective electrodes. An amplifier stage includes a plurality of differential amplifiers, each of the differential amplifiers being configured to provide an amplifier output signal based on a difference between a respective pair of the electrical signals. Channel detection logic is configured to provide channel data indicating an acceptability of each of the input channels based on an analysis of a common mode rejection of the amplifier output signals.Type: ApplicationFiled: November 23, 2020Publication date: April 8, 2021Inventors: SHAHABEDIN SHAHDOOSTFARD, QINGGUO ZENG, PING JIA, BRIAN P. GEORGE, KEVIN PONZIANI, QING LOU, DANIEL VARGHAI, JEFFREY B. ADAIR
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Patent number: 10874318Abstract: This disclosure relates to integrated channel integrity detection and to reconstruction of electrophysiological signals. An example system includes a plurality of input channels configured to receive respective electrical signals from a set of electrodes. An amplifier stage includes a plurality of differential amplifiers, each of the differential amplifiers being configured to provide an amplifier output signal based on a difference between a respective pair of the electrical signals. Channel detection logic is configured to provide channel data indicating an acceptability of each of the plurality of input channels based on an analysis of a common mode rejection of the amplifier output signals.Type: GrantFiled: March 6, 2018Date of Patent: December 29, 2020Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Shahabedin Shahdoostfard, Qingguo Zeng, Ping Jia, Brian P. George, Kevin Ponziani, Qing Lou, Daniel Varghai, Jeffrey B. Adair
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Patent number: 10729345Abstract: For example, one or more non-transitory computer-readable media includes executable instructions to perform a method. The method includes defining a plurality of spatial regions distributed across a geometric surface. At least one wave front that propagates across the geometric surface is detected based on electrical data representing electrophysiological signals for each of a plurality of nodes distributed on the geometric surface over at least one time interval. An indication of conduction velocity of the wave front is determined for at least one spatial region of the plurality of spatial regions during the time interval based on a duration that the wave front resides within the at least one spatial region. Slow conduction activity is identified for the at least one spatial region based on comparing the indication of conduction velocity relative to a threshold. Conduction data is stored in memory to represent each slow conduction event.Type: GrantFiled: May 4, 2018Date of Patent: August 4, 2020Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qing Lou, Jeffrey B. Adair, Qingguo Zeng, Ping Jia, Ryan Bokan, Connor Edel, Rahsean Ellis, Brian P. George, Raja Ghanem, Timothy G. Laske
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Publication number: 20200163570Abstract: An example method includes analyzing morphology and/or amplitude of each of a plurality of electrophysiological signals across a surface of a patient's body to identify candidate segments of each signal satisfying predetermined conduction pattern criteria. The method also includes determining a conduction timing parameter for each candidate segment in each of the electrophysiological signals.Type: ApplicationFiled: January 28, 2020Publication date: May 28, 2020Inventors: QING LOU, MEREDTH E. STONE, QINGGUO ZENG, JEFFREY B. ADAIR, CONNOR S. EDEL, PING JIA, KEVIN R. PONZIANI, BRIAN P. GEORGE, RYAN M. BOKAN, MATTHEW J. SABO, VLADIMIR A. TUROVSKIY, KETAL C. PATEL, CHARULATHA RAMANATHAN
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Patent number: 10575749Abstract: An example method includes analyzing morphology and/or amplitude of each of a plurality of electrophysiological signals across a surface of a patient's body to identify candidate segments of each signal satisfying predetermined conduction pattern criteria. The method also includes determining a conduction timing parameter for each candidate segment in each of the electrophysiological signals.Type: GrantFiled: April 27, 2017Date of Patent: March 3, 2020Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qing Lou, Meredith E. Stone, Qingguo Zeng, Jeffrey B. Adair, Connor S. Edel, Ping Jia, Kevin R. Ponziani, Brian P. George, Ryan M. Bokan, Matthew J. Sabo, Vladimir A. Turovskiy, Ketal C. Patel, Charulatha Ramanathan
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Publication number: 20190336023Abstract: For example, one or more non-transitory computer-readable media includes executable instructions to perform a method. The method includes defining a plurality of spatial regions distributed across a geometric surface. At least one wave front that propagates across the geometric surface is detected based on electrical data representing electrophysiological signals for each of a plurality of nodes distributed on the geometric surface over at least one time interval. An indication of conduction velocity of the wave front is determined for at least one spatial region of the plurality of spatial regions during the time interval based on a duration that the wave front resides within the at least one spatial region. Slow conduction activity is identified for the at least one spatial region based on comparing the indication of conduction velocity relative to a threshold. Conduction data is stored in memory to represent each slow conduction event.Type: ApplicationFiled: May 4, 2018Publication date: November 7, 2019Inventors: QING LOU, JEFFREY B. ADAIR, QINGGUO ZENG, PING JIA, RYAN BOKAN, CONNOR EDEL, RAHSEAN ELLIS, BRIAN P. GEORGE, RAJA GHANEM, TIMOTHY G. LASKE
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Publication number: 20190274568Abstract: This disclosure relates to integrated channel integrity detection and to reconstruction of electrophysiological signals. An example system includes a plurality of input channels configured to receive respective electrical signals from a set of electrodes. An amplifier stage includes a plurality of differential amplifiers, each of the differential amplifiers being configured to provide an amplifier output signal based on a difference between a respective pair of the electrical signals. Channel detection logic is configured to provide channel data indicating an acceptability of each of the plurality of input channels based on an analysis of a common mode rejection of the amplifier output signals.Type: ApplicationFiled: March 6, 2018Publication date: September 12, 2019Inventors: SHAHABEDIN SHAHDOOSTFARD, QINGGUO ZENG, PING JIA, BRIAN P. GEORGE, KEVIN PONZIANI, QING LOU, DANIEL VARGHAI, JEFFREY B. ADAIR
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Patent number: 10376173Abstract: An example method includes performing amplitude-based detection to determine location of R-peaks for a plurality of electrograms. The method also includes performing wavelet-based detection to determine location of R-peaks for the plurality of electrograms. The method also includes adjusting the location of the R-peaks determined by the wavelet-based detection of R-peaks based on the location of R-peaks determined by the amplitude-based detection of R-peaks. The method also includes storing, in memory, R-peak location data to specify R-peak locations for the plurality of electrograms based on the adjusting.Type: GrantFiled: April 27, 2017Date of Patent: August 13, 2019Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Brian P. George, Meredith E. Stone, Qingguo Zeng, Qing Lou, Connor S. Edel, Ping Jia, Jeffrey B. Adair, Vladimir A. Turovskiy, Matthew J. Sabo, Ryan M. Bokan, Ketal C. Patel, Charulatha Ramanathan, John E. Anderson, Andrew E. Hoover, Cheng Yao
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Patent number: 10194982Abstract: A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals.Type: GrantFiled: August 2, 2016Date of Patent: February 5, 2019Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Rémi Dubois, Brian P. George, Charulatha Ramanathan, Qingguo Zeng, Maria Strom, Venkatesh Vasudevan, Ryan Bokan, Ping Jia
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Patent number: 10117594Abstract: Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory.Type: GrantFiled: August 18, 2016Date of Patent: November 6, 2018Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qingguo Zeng, Ping Jia, Ryan Bokan, Brian P. George, Charulatha Ramanathan, Venkatesh Vasudevan, Maria Strom
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Patent number: 9977060Abstract: A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.Type: GrantFiled: September 19, 2016Date of Patent: May 22, 2018Assignee: Cardioinsight Technologies, Inc.Inventors: Brian P. George, Charulatha Ramanathan, Ping Jia, Qingguo Zeng, Venkatesh Vasudevan, Maria Strom, Ryan Bokan, Rémi Dubois
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Patent number: 9883813Abstract: A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.Type: GrantFiled: August 18, 2016Date of Patent: February 6, 2018Assignee: Cardioinsight Technologies, Inc.Inventors: Qingguo Zeng, Rémi DuBois, Ping Jia, Ryan Bokan, Venkatesh Vasudevan, Charulatha Ramanathan, Maria Strom, Brian P. George
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Publication number: 20170319088Abstract: An example method includes performing amplitude-based detection to determine location of R-peaks for a plurality of electrograms. The method also includes performing wavelet-based detection to determine location of R-peaks for the plurality of electrograms. The method also includes adjusting the location of the R-peaks determined by the wavelet-based detection of R-peaks based on the location of R-peaks determined by the amplitude-based detection of R-peaks. The method also includes storing, in memory, R-peak location data to specify R-peak locations for the plurality of electrograms based on the adjusting.Type: ApplicationFiled: April 27, 2017Publication date: November 9, 2017Inventors: BRIAN P. GEORGE, MEREDITH E. STONE, QINGGUO ZENG, QING LOU, CONNOR S. EDEL, PING JIA, JEFFREY B. ADAIR, VLADIMIR A. TUROVSKIY, MATTHEW J. SABO, RYAN M. BOKAN, KETAL C. PATEL, CHARULATHA RAMANATHAN, JOHN E. ANDERSON, ANDREW E. HOOVER, CHENG YAO
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Publication number: 20170319089Abstract: An example method includes analyzing morphology and/or amplitude of each of a plurality of electrophysiological signals across a surface of a patient's body to identify candidate segments of each signal satisfying predetermined conduction pattern criteria. The method also includes determining a conduction timing parameter for each candidate segment in each of the electrophysiological signals.Type: ApplicationFiled: April 27, 2017Publication date: November 9, 2017Inventors: QING LOU, MEREDITH E. STONE, QINGGUO ZENG, JEFFREY B. ADAIR, CONNOR S. EDEL, PING JIA, KEVIN R. PONZIANI, BRIAN P. GEORGE, RYAN M. BOKAN, MATTHEW J. SABO, VLADIMIR A. TUROVSKIY, KETAL C. PATEL, CHARULATHA RAMANATHAN