Patents by Inventor Brian p. LIEBERMAN

Brian p. LIEBERMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • -astatine containing radiotherapeutics for the treatment of cancer
    Patent number: 10457642
    Abstract: Described herein is an alpha-emitting radionuclide, 211At, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described herein, a compound of formula (I), wherein R1-R4, m, and n are defined herein, was prepared and utilized in in vitro and in vivo tumor targeting of alpha-emitting sigma-2 ligand in a breast cancer model. In one embodiment, the compound is 5-(211At)—N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: October 29, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daniel A. Pryma, Brian P. Lieberman, Mehran Makvandi, Robert H. Mach
  • 211-ASTATINE CONTAINING RADIOTHERAPEUTICS FOR THE TREATMENT OF CANCER
    Publication number: 20180162818
    Abstract: Described herein is an alpha-emitting radionuclide, 211At, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described herein, a compound of formula (I), wherein R1-R4, m, and n are defined herein, was prepared and utilized in in vitro and in vivo tumor targeting of alpha-emitting sigma-2 ligand in a breast cancer model. In one embodiment, the compound is 5-(211At)—N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide.
    Type: Application
    Filed: April 26, 2016
    Publication date: June 14, 2018
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Daniel A. PRYMA, Brian p. LIEBERMAN, Mehran MAKVANDI, Robert H. MACH