Patents by Inventor Brian Pak
Brian Pak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230400392Abstract: The present disclosure provides a method of cell sedimentation and retention of target cells, for example circulating tumour cells, CTC, from a fluid sample onto a solid support. The method comprises placing a fluid medium comprising the target cells in a fluid chamber, the fluid chamber having an open end sealed against a surface of the solid support. The method further comprises subjecting the fluid medium to centrifugation within the fluid chamber to induce sedimentation of the target cells and promote cell adhesion to the surface of the solid support. The method further comprises, post-centrifugation, positioning a fluid absorbing element in the fluid chamber to remove fluid from the fluid chamber. The method further comprises controlling a flow rate of the fluid being absorbed by the fluid absorbing element such that the sedimented cells are not detached from the surface of the solid support.Type: ApplicationFiled: February 27, 2023Publication date: December 14, 2023Inventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: 11604120Abstract: The present disclosure provides a cell harvesting method for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology.Type: GrantFiled: July 20, 2022Date of Patent: March 14, 2023Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: 11604119Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.Type: GrantFiled: July 20, 2022Date of Patent: March 14, 2023Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: 11435267Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.Type: GrantFiled: June 14, 2022Date of Patent: September 6, 2022Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: 10610104Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.Type: GrantFiled: December 7, 2017Date of Patent: April 7, 2020Assignee: Progenity, Inc.Inventors: Brian Pak, John Mitchell McLean, Paul Timothy Smith, Mitchell Lawrence Jones, Christopher Loren Wahl
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Publication number: 20180206769Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.Type: ApplicationFiled: December 7, 2017Publication date: July 26, 2018Inventors: Brian Pak, John Mitchell McLean, Paul Timothy Smith, Mitchell Lawrence Jones, Christopher Loren Wahl
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Patent number: 9492154Abstract: Devices and methods for retracting tissue, such as bowels and organs, within the body of a patient are generally disclosed. In particular, the present disclosure describes surgical retractors having a series of intersecting strands defining openings there between, wherein the openings are enlargeable by slidable passage of the strands relative to one another. The present disclosure also teaches surgical retractors having a frame that defines a central opening and a supporting structure extending across the central opening and defining a plurality of openings, wherein the frame extends through the openings. In some embodiments, a surgical retractor comprises a monolithic polymeric structure extending across the central opening defined by a frame. Other embodiments and methods are disclosed.Type: GrantFiled: July 9, 2015Date of Patent: November 15, 2016Assignee: Cook Medical Technologies LLCInventors: Jeffry S. Melsheimer, Leslie Cook, Brian Pak-Yun Feng, Nathan S. Steinbrunner, Joshua Haines, Amro Kamel
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Patent number: 9358098Abstract: Described, in certain aspects, are medical devices that can be used to anchor graft materials to bodily structures. These devices comprise an implantable graft structure and tissue ingrowth material. This implantable graft structure is comprised of a body of persistent material having a first face and one or more openings defined therein, wherein the persistent material body first face is configured for opposing a bodily structure wall upon implantation. This tissue ingrowth material is positioned at the one or more persistent material body openings, and is configured for receiving tissue ingrowth from the bodily structure wall effective to anchor the graft structure to the bodily structure wall. The invention also provides methods utilizing these and other inventive medical devices, for example, to anchor graft materials to vascular vessel walls and/or other bodily structures.Type: GrantFiled: February 16, 2010Date of Patent: June 7, 2016Assignee: Cook Medical Technologies LLCInventor: Brian Pak-Yun Feng
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Patent number: 9275110Abstract: A database system performs hash join process for processing queries that join an inner and an outer database table. The hash join processes builds a hash table in memory for the inner table. The database system receives a limit on the memory for storing the hash table. The database system maximizes the number of partitions stored in memory for the hash table. If the hash table exceeds the limit of the memory while adding rows from the inner table, the database system selects a partition for spilling to a persistent storage. The partition selected for spilling to may be the largest partition or a partition larger than most of the partitions. The database system initializes the hash table to a number of partitions that is substantially equal to half of the total number of blocks that can be stored within the specified limit of memory for the hash table.Type: GrantFiled: March 1, 2013Date of Patent: March 1, 2016Assignee: ParAccel LLCInventors: Mayank Pradhan, David Galimberti, Brian Pak-Ning Chu, David Wilhite, Jr., Adam Birnbaum, Raymi Dyskant
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Patent number: 9251155Abstract: A database system maintains table data in sorted order. The table data becomes unsorted over time due to add, delete, and update operations. These operations are performed such that the table comprises an initial sorted region followed by an unsorted region. The database system performs an incremental operation to rewrite the table in sorted order. The database system partitions the unsorted region into a plurality of partitions comprising sorted rows within each partition. The database system iteratively merges rows from the partitions to the sorted region of the table. The database system selects a set of lowest tanked rows from the partitions. The database system merges these lowest ranked rows with the sorted region while maintaining the sort order of the sorted region. The database system repeats these steps until all the partitions are processed. The database may store data in columnar fashion.Type: GrantFiled: March 15, 2013Date of Patent: February 2, 2016Assignee: ParAccel LLCInventors: David Benedict Galimberti, Brian Pak-ning Chu
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Patent number: 9192710Abstract: A catheter for use in the extracorporeal treatment of bodily fluids comprises a catheter body having a withdrawal port, an infusion port, and a plurality of lumens therein. The lumens comprise two or more withdrawal lumens that merge to form a single lumen proximal to withdrawal ports for transport of fluids withdrawn from a body vessel through the withdrawal port to an extracorporeal treatment unit, such as a dialyzer. The lumens also comprise an infusion lumen for infusion of treated fluids from the extracorporeal treatment unit through the infusion port into the vessel. The infusion lumen is disposed substantially at the center of the catheter body, while the withdrawal lumens extend longitudinally adjacent the infusion lumen along the catheter body length. A manifold may be provided at the proximal end of the catheter body to include the merger of the withdrawal lumens.Type: GrantFiled: July 10, 2013Date of Patent: November 24, 2015Assignee: COOK MEDICAL TECHNOLOGIES LLCInventors: Brian Pak-Yun Feng, Christopher D. Bosel
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Publication number: 20150305734Abstract: Devices and methods for retracting tissue, such as bowels and organs, within the body of a patient are generally disclosed. In particular, the present disclosure describes surgical retractors having a series of intersecting strands defining openings there between, wherein the openings are enlargeable by slidable passage of the strands relative to one another. The present disclosure also teaches surgical retractors having a frame that defines a central opening and a supporting structure extending across the central opening and defining a plurality of openings, wherein the frame extends through the openings. In some embodiments, a surgical retractor comprises a monolithic polymeric structure extending across the central opening defined by a frame. Other embodiments and methods are disclosed.Type: ApplicationFiled: July 9, 2015Publication date: October 29, 2015Inventors: Jeffry S. Melsheimer, Leslie Cook, Brian Pak-Yun Feng, Nathan S. Steinbrunner, Joshua Haines, Amro Kamel
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Publication number: 20140250142Abstract: A database system performs hash join process for processing queries that join an inner and an outer database table. The hash join processes builds a hash table in memory for the inner table. The database system receives a limit on the memory for storing the hash table. The database system maximizes the number of partitions stored in memory for the hash table. If the hash table exceeds the limit of the memory while adding rows from the inner table, the database system selects a partition for spilling to a persistent storage. The partition selected for spilling to may be the largest partition or a partition larger than most of the partitions. The database system initializes the hash table to a number of partitions that is substantially equal to half of the total number of blocks that can be stored within the specified limit of memory for the hash table.Type: ApplicationFiled: March 1, 2013Publication date: September 4, 2014Applicant: ParAccel, Inc.Inventors: Mayank Pradhan, David Galimberti, Brian Pak-Ning Chu, David Wilhite, JR., Adam Birnbaum, Raymi Dyskant
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Publication number: 20130296773Abstract: A catheter for use in the extracorporeal treatment of bodily fluids comprises a catheter body having a withdrawal port, an infusion port, and a plurality of lumens therein. The lumens comprise two or more withdrawal lumens that merge to form a single lumen proximal to withdrawal ports for transport of fluids withdrawn from a body vessel through the withdrawal port to an extracorporeal treatment unit, such as a dialyzer. The lumens also comprise an infusion lumen for infusion of treated fluids from the extracorporeal treatment unit through the infusion port into the vessel. The infusion lumen is disposed substantially at the center of the catheter body, while the withdrawal lumens extend longitudinally adjacent the infusion lumen along the catheter body length. A manifold may be provided at the proximal end of the catheter body to include the merger of the withdrawal lumens.Type: ApplicationFiled: July 10, 2013Publication date: November 7, 2013Inventors: Brian Pak-Yun Feng, Christopher D. Bosel
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Patent number: 8496607Abstract: A catheter for use in the extracorporeal treatment of bodily fluids comprises a catheter body having a withdrawal port, an infusion port, and a plurality of lumens therein. The lumens comprise two or more withdrawal lumens that merge to form a single lumen proximal to withdrawal ports for transport of fluids withdrawn from a body vessel through the withdrawal port to an extracorporeal treatment unit, such as a dialyzer. The lumens also comprise an infusion lumen for infusion of treated fluids from the extracorporeal treatment unit through the infusion port into the vessel. The infusion lumen is disposed substantially at the center of the catheter body, while the withdrawal lumens extend longitudinally adjacent the infusion lumen along the catheter body length. A manifold may be provided at the proximal end of the catheter body to include the merger of the withdrawal lumens.Type: GrantFiled: December 4, 2009Date of Patent: July 30, 2013Assignee: Cook Medical Technologies LLCInventors: Brian Pak-Yun Feng, Christopher D. Bosel
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Publication number: 20110202075Abstract: Described, in certain aspects, are medical devices that can be used to anchor graft materials to bodily structures. These devices comprise an implantable graft structure and tissue ingrowth material. This implantable graft structure is comprised of a body of persistent material having a first face and one or more openings defined therein, wherein the persistent material body first face is configured for opposing a bodily structure wall upon implantation. This tissue ingrowth material is positioned at the one or more persistent material body openings, and is configured for receiving tissue ingrowth from the bodily structure wall effective to anchor the graft structure to the bodily structure wall. The invention also provides methods utilizing these and other inventive medical devices, for example, to anchor graft materials to vascular vessel walls and/or other bodily structures.Type: ApplicationFiled: February 16, 2010Publication date: August 18, 2011Inventor: Brian Pak-Yun Feng
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Publication number: 20110137225Abstract: A catheter for use in the extracorporeal treatment of bodily fluids comprises a catheter body having a withdrawal port, an infusion port, and a plurality of lumens therein. The lumens comprise two or more withdrawal lumens that merge to form a single lumen proximal to withdrawal ports for transport of fluids withdrawn from a body vessel through the withdrawal port to an extracorporeal treatment unit, such as a dialyzer. The lumens also comprise an infusion lumen for infusion of treated fluids from the extracorporeal treatment unit through the infusion port into the vessel. The infusion lumen is disposed substantially at the center of the catheter body, while the withdrawal lumens extend longitudinally adjacent the infusion lumen along the catheter body length. A manifold may be provided at the proximal end of the catheter body to include the merger of the withdrawal lumens.Type: ApplicationFiled: December 4, 2009Publication date: June 9, 2011Applicant: Cook Critical Care IncorporatedInventors: Brian Pak-Yun Feng, Christopher D. Bosel
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Publication number: 20090233313Abstract: The invention features methods and devices for the detection of antibodies. The invention also features methods for diagnosing disease and evaluating the efficacy of treatment of a subject with a disease.Type: ApplicationFiled: March 11, 2009Publication date: September 17, 2009Applicant: Axela Inc.Inventors: Brian Pak, Jean-Francois Houle, David Wong