Patents by Inventor Brian Patrick Chekal

Brian Patrick Chekal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms of a selective CDK4/6 inhibitor
    Patent number: 10723730
    Abstract: This invention relates to the crystalline free base of acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, formula (1) having improved properties, to pharmaceutical compositions and dosage forms comprising the free base, and to methods for making and using such compounds, compositions and dosage forms in the treatment of cell proliferative diseases, such as cancer.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: July 28, 2020
    Assignee: Pfizer Inc.
    Inventors: Brian Patrick Chekal, Nathan D. Ide
  • SOLID FORMS OF A SELECTIVE CDK4/6 INHIBITOR
    Publication number: 20180065964
    Abstract: This invention relates to the crystalline free base of acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, formula (1) having improved properties, to pharmaceutical compositions and dosage forms comprising the free base, and to methods for making and using such compounds, compositions and dosage forms in the treatment of cell proliferative diseases, such as cancer.
    Type: Application
    Filed: November 9, 2017
    Publication date: March 8, 2018
    Applicant: PFIZER INC.
    Inventors: Brian Patrick Chekal, Nathan D. Ide
  • SOLID FORMS OF A SELECTIVE CDK4/6 INHIBITOR
    Publication number: 20160002223
    Abstract: This invention relates to the crystalline free base of acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, formula (1) having improved properties, to pharmaceutical compositions and dosage forms comprising the free base, and to methods for making and using such compounds, compositions and dosage forms in the treatment of cell proliferative diseases, such as cancer.
    Type: Application
    Filed: February 8, 2014
    Publication date: January 7, 2016
    Applicant: PFIZER INC.
    Inventors: Brian Patrick Chekal, Nathan D. Ide
  • Crystalline forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyondazole suitable for the treatment of abnormal cell growth in mammals
    Patent number: 8791140
    Abstract: The present invention relates to crystalline polymorphic and amorphous form of 6-[2-(methylcarbamoyl)phenyl sulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one polymorphic form and to the therapeutic or prophylactic use of such polymorphic forms and compositions.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: July 29, 2014
    Assignee: Pfizer Inc.
    Inventors: Anthony Michael Campeta, Brian Patrick Chekal, Robert Alan Singer
  • CRYSTALLINE FORMS OF 6-[2-(METHYLCARBAMOYL)PHENYLSULFANYL]-3-E-[2-(PYRIDIN-2-YL)ETHENYL]INDAZOLE SUITABLE FOR THE TREATMENT OF ABNORMAL CELL GROWTH IN MAMMALS
    Publication number: 20100179329
    Abstract: The present invention relates to crystalline polymorphic and amorphous form of 6-[2-(methylcarbamoyl)phenyl sulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one polymorphic form and to the therapeutic or prophylactic use of such polymorphic forms and compositions.
    Type: Application
    Filed: March 25, 2008
    Publication date: July 15, 2010
    Inventors: Anthony Michael Campeta, Brian Patrick Chekal, Robert William McLaughlin, Robert Alan Singer